Reduced Endothelial Vasomotor Function and Enhanced Neointimal Formation after Vascular Injury in a Rat Model of Blood Pressure Lability

Eto, Masato; Toba, Kenji; Akishita, Masahiro; Kozaki, Koichi; Watanabe, Takeru; Kim, Seungbum; Hashimoto, Masayoshi; Sudoh, Noriko; Yoshizumi, Masao; Ouchi, Yasuyoshi

doi:10.1291/hypres.26.991

Cited by 79 publications

(67 citation statements)

References 39 publications

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“…Eto et al suggested that increased blood pressure variability impaired endotherial function of the aorta by inhibiting NO production in experiments using chronic sinoaortic denervated rats (24). Thus, our finding indicates that blood pressure variability, especialy in the morning, is related to increased carotid IMT.…”

Section: Blood Pressure and Target Organ Damagesupporting

confidence: 62%

Isolated Home Hypertension in the Morning is Associated with Target Organ Damage in Patients with Type 2 Diabetes

Sakaguchi

Horimatsu

Kishi

et al. 2005

JAT

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To investigate the relationship between the blood pressure control level and cardiovascular risk in type 2 diabetic patients, we evaluated home blood pressure, office blood pressure, biochemical data, and carotid echographic and echocardiographic findings in 148 patients with type 2 diabetes. According to the criteria for hypertension in the guidelines of the Japanese Society of Hypertension, we classified patients into a normotensive group with home systolic blood pressure in the morning (morning HSBP) < 135 mmHg and office systolic blood pressure (OSBP) < 140 mmHg, an office hypertension group with a morning HSBP < 135 mmHg and OSBP ≥ ≥ ≥ ≥ ≥ 140 mmHg, an isolated home hypertension in the morning group with morning HSBP ≥ ≥ ≥ ≥ ≥ 135 mmHg and OSBP < 140 mmHg, and a sustained hypertension group with morning HSBP ≥ ≥ ≥ ≥ ≥ 135 mmHg and OSBP ≥ ≥ ≥ ≥ ≥ 140 mmHg. In the isolated home hypertension in the morning group, the fasting insulin level, urinary albumin excretion, maximum carotid artery intima-media complex thickness, and left ventricular posterior wall thickness were significantly higher and the coefficient of variation for RR intervals was significantly lower than in the normotensive group. These results suggest that isolated home hypertension in the morning is a risk factor for target organ damage in type 2 diabetic patients. J Atheroscler Thromb, 2005; 12: 225-231.

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Section: Blood Pressure and Target Organ Damagesupporting

confidence: 62%

Isolated Home Hypertension in the Morning is Associated with Target Organ Damage in Patients with Type 2 Diabetes

Sakaguchi

Horimatsu

Kishi

et al. 2005

JAT

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“…The reason why visit-to-visit BPV is associated with endothelial dysfunction needs to be considered. Eto et al 25 showed that increased BPV, independent of average BP level, impaired endothelial function by inhibiting NO production and enhancing neointimal formation, thereby contributing to atherogenesis in rats. In contrast, it has been proposed that endothelial dysfunction may cause high BPV.…”

Section: Discussionmentioning

confidence: 99%

The relationships between visit-to-visit blood pressure variability and renal and endothelial function in chronic kidney disease

Nakano¹,

Morimoto²,

Nakahigashi³

et al. 2014

Hypertens Res

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“…First, it has been reported that in sinoaortic-denervated rats (an experimental model of high variability in BP without hypertension), variability in BP is a more critical determinant than BP level for cardiac damage, renal lesions and aortic hypertrophy. 17 Second, Eto et al 18 demonstrated that sinoaortic denervation reduced endothelium-dependent vasorelaxation and enhanced neointimal formation after balloon injury. These results suggest that increased BP fluctuations, independent of average BP level, may contribute to atherogenesis.…”

Section: Coefficient Variation Of Home Blood Pressure E Ushigome Et Almentioning

confidence: 99%

The coefficient variation of home blood pressure is a novel factor associated with macroalbuminuria in type 2 diabetes mellitus

et al. 2011

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The purpose of this study was to investigate the association between day-by-day variability in home blood pressure (HBP) on 14 consecutive days and macroalbuminuria in patients with type 2 diabetes. We compared the coefficient of variation (CV) of HBP in 858 Japanese patients with and without macroalbuminuria. Next, we analyzed the relationship between the logarithm of urinary albumin excretion (UAE) and the CV of HBP using linear regression analysis. Then, we evaluated the association between the CV of HBP and macroalbuminuria, defined as UAE X300 mg g À1 creatinine, using logistic regression analysis. The CVs of morning and evening systolic blood pressure (SBP) were significantly greater in patients with macroalbuminuria than in those without (8.08±3.35 vs. 7.19±2.25%, Po0.05 and 9.01±3.58 vs. 7.98±2.57%, Po0.05, respectively). Multivariate linear regression analyses indicated that the CVs of morning SBP (Po0.05) and diastolic blood pressure (DBP; Po0.05), and those of evening SBP (Po0.05) were the independent explanatory variables for the logarithm of UAE. Multivariate logistic regression analyses also demonstrated that the odds ratio for the CVs of morning SBP, morning DBP and evening SBP for macroalbuminuria were 1.35 (Po0.05), 1.29 (Po0.05) and 1.44 (Po0.05), respectively. We conclude that the CV of HBP is correlated with macroalbuminuria, independent of the known risk factors, in Japanese patients with type 2 diabetes.

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Reduced Endothelial Vasomotor Function and Enhanced Neointimal Formation after Vascular Injury in a Rat Model of Blood Pressure Lability

Cited by 79 publications

References 39 publications

Isolated Home Hypertension in the Morning is Associated with Target Organ Damage in Patients with Type 2 Diabetes

Isolated Home Hypertension in the Morning is Associated with Target Organ Damage in Patients with Type 2 Diabetes

The relationships between visit-to-visit blood pressure variability and renal and endothelial function in chronic kidney disease

The coefficient variation of home blood pressure is a novel factor associated with macroalbuminuria in type 2 diabetes mellitus

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