Reduced Expression of Adipose Triglyceride Lipase Enhances Tumor Necrosis Factor α-induced Intercellular Adhesion Molecule-1 Expression in Human Aortic Endothelial Cells via Protein Kinase C-dependent Activation of Nuclear Factor-κB

Inoue, Tomoaki; Kobayashi, Kazuo; Inoguchi, Toyoshi; Sonoda, Noriyuki; Fujii, Masakazu; Maeda, Yasutaka; Fujimura, Yoshinori; Miura, Daisuke; Hirano, Ken; Takayanagi, Ryoichi

doi:10.1074/jbc.m111.285650

Cited by 34 publications

(29 citation statements)

References 37 publications

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“…The lower phases (containing lipid) from both centrifugation steps were combined and dried under nitrogen gas. The total DAG contents were measured by high-performance liquid chromatographyetandem mass spectrometry as previously described [6,22].…”

Section: Measurement Of Cardiac Tg and Dag Contentsmentioning

confidence: 99%

GLP-1 analog liraglutide protects against cardiac steatosis, oxidative stress and apoptosis in streptozotocin-induced diabetic rats

et al. 2015

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Section: Measurement Of Cardiac Tg and Dag Contentsmentioning

confidence: 99%

GLP-1 analog liraglutide protects against cardiac steatosis, oxidative stress and apoptosis in streptozotocin-induced diabetic rats

et al. 2015

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“…This cleavage may be triggered by cytokines such as transforming growth factor-b (TGF-b), tumor necrosis factor a and interleukin-1a (IL-1a) or sICAM-1 may be working with cytokines to regulate BTB dynamics because cytokines have been shown to disrupt barrier function (Lie et al, 2011;Lui et al, 2001;Lui et al, 2003). Indeed, ICAM-1 is known to be upregulated by pro-inflammatory cytokines (Inoue et al, 2011;Turner et al, 2011;Wertheimer et al, 1992). Another pool of sICAM-1, produced by alternative splicing (Wakatsuki et al, 1995), may also exist in the seminiferous epithelium, and this pool may be interfering with ICAM-1-mediated cell adhesion above preleptotene/leptotene spermatocytes (Fig.…”

Section: Icam-1 In the Testis 5683mentioning

confidence: 99%

Intercellular adhesion molecule-1 is a regulator of blood–testis barrier function

Xiao

Cheng

Mruk

2012

Journal of Cell Science

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SummaryThe mechanism underlying the movement of preleptotene/leptotene spermatocytes across the blood-testis barrier (BTB) during spermatogenesis is not well understood largely owing to the fact that the BTB, unlike most other blood-tissue barriers, is composed of several co-existing and co-functioning junction types. In the present study, we show that intercellular adhesion molecule-1 [ICAM-1, a Sertoli and germ cell adhesion protein having five immunoglobulin (Ig)-like domains, in addition to transmembrane and cytoplasmic domains] is a regulator of BTB integrity. Initial experiments showed ICAM-1 to co-immunoprecipitate and co-localize with tight junction and basal ectoplasmic specialization proteins such as occludin and N-cadherin, which contribute to BTB function. More importantly, overexpression of ICAM-1 in Sertoli cells in vitro enhanced barrier function when monitored by transepithelial electrical resistance measurements, illustrating that ICAM-1-mediated adhesion can promote BTB integrity. On the other hand, overexpression of a truncated form of ICAM-1 that consisted only of the five Ig-like domains (sICAM-1; this form of ICAM-1 is known to be secreted) elicited an opposite effect when Sertoli cell barrier function was found to be perturbed in vitro; in this case, sICAM-1 overexpression resulted in the downregulation of several BTB constituent proteins, which was probably mediated by Pyk2/p-Pyk2-Y402 and c-Src/pSrc-Y530. These findings were expanded to the in vivo level when BTB function was found to be disrupted following sICAM-1 overexpression. These data illustrate the existence of a unique mechanism in the mammalian testis where ICAM-1 can either positively or negatively regulate BTB function.

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“…In addition, it has no direct relationship with Annals of Nuclear Cardiology J-STAGE Advance published date: August 23, 2017 doi: 10.17996/anc. [17][18][19][20][21][22][23][24][25][26][27][28] plasma TG levels, because regulatory mechanism and responsible enzymes are different intracellularly from those in plasma (7). The probands for TGCV carried genetic mutations in the adipose triglyceride lipase (ATGL), which is the ratelimiting enzyme for hydrolysis of intracellular TG (8).…”

Section: T Riglyceride Deposit Cardiomyovasculopathy (Tgcv) Is Amentioning

confidence: 99%

Imaging Modalities for Triglyceride Deposit Cardiomyovasculopathy

Higashi

Ikeda

Miyauchi

et al. 2017

Annals of Nuclear Cardiology

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Triglyceride deposit cardiomyovasculopathy (TGCV) is a novel clinical entity we found in patients withThese results suggest that TGCV might be difficult to diagnose in daily clinics, however be more prevalent than expected, and a possible important cause of cardiac death. This review article focuses on imaging modalities to evaluate cardiomyovascular TG accumulation of this novel disease. Data and images are shown from pathological analyses, imaging mass spectrometry, myocardial scintigraphy with a radioactive analogue for LCFA, iodine-123-β-methyl iodophenyl-pentadecanoic acid, MR spectroscopy, and CT-based TG imagings in primary TGCV patients with genetic ATGL deficiency, which is ultra-rare, but the monogenic model.

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Reduced Expression of Adipose Triglyceride Lipase Enhances Tumor Necrosis Factor α-induced Intercellular Adhesion Molecule-1 Expression in Human Aortic Endothelial Cells via Protein Kinase C-dependent Activation of Nuclear Factor-κB

Cited by 34 publications

References 37 publications

GLP-1 analog liraglutide protects against cardiac steatosis, oxidative stress and apoptosis in streptozotocin-induced diabetic rats

GLP-1 analog liraglutide protects against cardiac steatosis, oxidative stress and apoptosis in streptozotocin-induced diabetic rats

Intercellular adhesion molecule-1 is a regulator of blood–testis barrier function

Imaging Modalities for Triglyceride Deposit Cardiomyovasculopathy

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