Reduced Expression of Antimicrobial Palate, Lung and Nasal Epithelial Clone (PLUNC) protein in Polyps from Patients with Chronic Rhinosinusitis is Due to Decreased Number of Glands

Seshadri, Sudarshan; Rosati, Mariel G.; Lin, David C.; Carter, R.; Norton, James E.; Kato, Ayako; Suh, Lydia; Peters, Anju T.; Chandra, Ramamurti; Harris, Kathleen E.; Chu, Hong Wei; Conley, David B.; Tan, Bruce K.; Grammer, L.; Kern, Richard A.; Schleimer, R.P.

doi:10.1016/j.jaci.2010.12.559

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 In the case of PLUNC (and probably lysozyme and lactoferrin), the reduced expression is restricted to the NP tissue, whereas psoriasin levels are reduced in epithelium throughout the nasal cavity in patients with CRS. 30-33 …”

Section: Pathophysiology Of Crsmentioning

confidence: 99%

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

Akdiş

Bachert

Cingi

et al. 2013

Journal of Allergy and Clinical Immunology

524

403

View full text Add to dashboard Cite

Chronic rhinosinusitis (CRS) is a complex disease consisting of several disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease subgroups is possibly the greatest obstacle in understanding the causes of CRS and improving treatment. It is generally agreed that there are clinically relevant CRS phenotypes defined by an observable characteristic or trait, such as the presence or absence of nasal polyps. Defining the phenotype of the patient is useful in making therapeutic decisions. However, clinical phenotypes do not provide full insight into all underlying cellular and molecular pathophysiologic mechanisms of CRS. Recognition of the heterogeneity of CRS has promoted the concept that CRS consists of multiple groups of biological subtypes, or “endotypes,” which are defined by distinct pathophysiologic mechanisms that might be identified by corresponding biomarkers. Different CRS endotypes can be characterized by differences in responsiveness to different treatments, including topical intranasal corticosteroids and biological agents, such as anti–IL-5 and anti-IgE mAb, and can be based on different biomarkers that are linked to underlying mechanisms. CRS has been regarded as a single disease entity in clinical and genetic studies in the past, which can explain the failure to identify consistent genetic and environmental correlations. In addition, better identification of endotypes might permit individualization of therapy that can be targeted against the pathophysiologic processes of a patient's endotype, with potential for more effective treatment and better patient outcomes.

show abstract

Section: Pathophysiology Of Crsmentioning

confidence: 99%

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

Akdiş

Bachert

Cingi

et al. 2013

Journal of Allergy and Clinical Immunology

524

403

View full text Add to dashboard Cite

show abstract

“…These innate responses in ECs are modulated in part by IL-22 and its receptor IL-22R [ 117 , 118 ] which act in part through the transcription factor STAT 3, broadly mediating mucosal host defense and epithelial repair [ 119 – 122 ]. Decreased expression of some host defense molecules has been associated with CRS [ 123 – 127 ]. While the mechanism for this weakened host defense is unclear, diminished expression of IL-22R [ 128 ] and blunting of the STAT 3 pathway [ 129 ] have been reported in CRS.…”

Section: Epithelial Barrier and Innate Immunitymentioning

confidence: 99%

“…In health, this maintains mucosal homeostasis with (a) tolerance of allergens and commensals and (b) defense against pathogens without the development of chronic inflammation. CRSwNP is characterized by chronic and excessive Th2 inflammation and the specific EC cytokines IL-25, IL-33 and TSLP have been implicated in disease pathogenesis via effects on dendritic cells and type 2 ILCs [ 127 – 139 ]. In support of this hypothesis, large numbers of Type 2 ILCs are present in nasal polyps [ 140 ] and high levels of TSLP have been identified suggesting a key role for this cytokine in polyp pathogenesis [ 141 – 145 ].…”

Section: Epithelial Barrier and Innate Immunitymentioning

confidence: 99%

ICON: chronic rhinosinusitis

Bachert¹,

Pawankar

Zhang

et al. 2014

World Allergy Organization Journal

203

185

View full text Add to dashboard Cite

Chronic rhinosinusitis (CRS) is a public health problem that has a significant socio-economic impact. Moreover, the complexity of this disease due to its heterogeneous nature based on the underlying pathophysiology - leading to different disease variants - further complicates our understanding and directions for the most appropriate targeted treatment strategies. Several International/national guidelines/position papers and/or consensus documents are available that present the current knowledge and treatment strategies for CRS. Yet there are many challenges to the management of CRS especially in the case of the more severe and refractory forms of disease. Therefore, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), a collaboration between EAACI, AAAAI, ACAAI, and WAO, has decided to propose an International Consensus (ICON) on Chronic Rhinosinusitis. The purpose of this ICON on CRS is to highlight the key common messages from the existing guidelines, the differences in recommendations as well as the gaps in our current knowledge of CRS, thus providing a concise reference. In this document we discuss the definition of the disease, its relevance, pharmacoeconomics, pathophysiology, phenotypes and endotypes, genetics and risk factors, natural history and co-morbidities as well as clinical manifestations and treatment options in both adults and children comprising pharmacotherapy, surgical interventions and more recent biological approaches. Finally, we have also highlighted the unmet needs that wait to be addressed through future research.

show abstract

Reduced Expression of Antimicrobial Palate, Lung and Nasal Epithelial Clone (PLUNC) protein in Polyps from Patients with Chronic Rhinosinusitis is Due to Decreased Number of Glands

Cited by 2 publications

References 0 publications

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

ICON: chronic rhinosinusitis

Contact Info

Product

Resources

About