Reduced expression of chemerin is associated with poor clinical outcome in acute myeloid leukemia

Zhang, Jing; Zhou, Jiao; Tang, Xi; Zhou, Lingsha; Zhai, Ling-Ling; Vanessa, Minse Evola-Deniz; Yi, Jing; Yi, Yun-Yun; Jiang, Lin; Qian, Jun; Deng, Zhaoqun

doi:10.18632/oncotarget.21440

Cited by 12 publications

(8 citation statements)

References 35 publications

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“…The same group performed a cohort study of 149 patients, 32 of whom had high chemerin expression and 117 of whom had low expression, with no significant variability in certain gene mutations, white blood cell count, platelets, and hemoglobin, and found that patients with low chemerin expression correlated with poorer overall survival. Moreover, multivariate analysis on parameters such as age, various gene mutations, chemerin expression, karyotypic classifications, and white blood cell count verified that chemerin was independently able to prognosticate AML patients, while univariate analysis of chemerin expression levels showed that high chemerin expression was associated with positive prognosis ( 22 ). In terms of chemerin receptor expression levels (independent of associations between chemerin expression and clinical outcome), a different group showed that CCRL2 was overexpressed in AML, identifying the non-classically signaling chemerin receptor as a potential therapeutic target, along with other GPCRs that were also overexpressed ( 37 ).…”

Section: Cancersmentioning

confidence: 99%

“…As expected, these recent studies have confirmed the notion that chemerin's functions in cancer are context driven. In some cancer types [e.g., glioblastoma, mesothelioma, neuroblastoma, squamous cell carcinoma of the esophagus, and squamous cell carcinoma of the oral tongue (SCCOT)], chemerin is upregulated ( 16 – 22 ). In most cancer types [e.g., acute myeloid leukemia (AML), adrenocortical carcinoma (ACC), breast cancer, Ewing sarcoma, hepatocellular carcinoma, melanoma, non-small cell lung cancer (NSCLC), prostate cancer, and squamous cell carcinoma of the skin] chemerin is downregulated, likely via hypermethylation of RARRES2 ( 15 , 19 , 23 – 28 ) (Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms and Functions of Chemerin in Cancer: Potential Roles in Therapeutic Intervention

2018

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Chemerin [RARRES2 [retinoic acid receptor responder 2], TIG2 [tazarotene induced gene 2 (TIG2)]] is a multifunctional cytokine initially described in skin cultures upon exposure to the synthetic retinoid tazarotene. Its secreted pro-form, prochemerin, is widely expressed, found systemically, and is readily converted into active chemerin by various proteases. Subsequent studies elucidated major roles of chemerin as both a leukocyte chemoattractant as well as an adipokine. Chemerin's main chemotactic receptor, the G-protein coupled receptor CMKLR1, is expressed on macrophages, dendritic, and NK cells. With respect to its role in immunology, chemerin mediates trafficking of these cells to sites of inflammation along its concentration gradient, and likely helps coordinate early responses, as it has been shown to have antimicrobial and angiogenic properties, as well. Recently, there has been mounting evidence that chemerin is an important factor in various cancers. As with its role in immune responses—where it can act as both a pro- and anti-inflammatory mediator—the potential functions or correlations chemerin has in or with cancer appears to be context dependent. Most studies, however, suggest a downregulation or loss of chemerin/RARRES2 in malignancies compared to the normal tissue counterparts. Here, we perform a comprehensive review of the literature to date and summarize relevant findings in order to better define the roles of chemerin in the setting of the tumor microenvironment and tumor immune responses, with an ultimate focus on the potential for therapeutic intervention.

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Section: Cancersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanisms and Functions of Chemerin in Cancer: Potential Roles in Therapeutic Intervention

2018

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“…In patients with AML, low chemerin expression correlated with poorer overall survival. It was shown that chemerin was independently able to prognosticate AML patients, and high chemerin expression was associated with positive prognosis [85]. Chemerin receptor CCRL2 was reported to be overexpressed in AML cells and was suggested to be a potential therapeutic target [86].…”

Section: Chemerin and Cancermentioning

confidence: 99%

Chemerin and Cancer

Treeck

Buechler²,

Ortmann

2019

IJMS

108

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Chemerin is a multifunctional adipokine with established roles in inflammation, adipogenesis and glucose homeostasis. Increasing evidence suggest an important function of chemerin in cancer. Chemerin’s main cellular receptors, chemokine-like receptor 1 (CMKLR1), G-protein coupled receptor 1 (GPR1) and C-C chemokine receptor-like 2 (CCRL2) are expressed in most normal and tumor tissues. Chemerin’s role in cancer is considered controversial, since it is able to exert both anti-tumoral and tumor-promoting effects, which are mediated by different mechanisms like recruiting innate immune defenses or activation of endothelial angiogenesis. For this review article, original research articles on the role of chemerin and its receptors in cancer were considered, which are listed in the PubMed database. Additionally, we included meta-analyses of publicly accessible DNA microarray data to elucidate the association of expression of chemerin and its receptors in tumor tissues with patients’ survival.

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“…Chemerin expression is different depending on the tumor type 10 . Chemerin has been shown to be downregulated compared to normal tissue counterparts in hepatocellular carcinoma 11 , melanoma 12 , non-small cell lung cancer 13 , adrenocortical carcinoma 14 , prostate cancer 15 , and acute myeloid leukemia 16 . In contrast, chemerin is significantly upregulated in glioblastoma 17 , mesothelioma, and squamous cell carcinoma 18 .…”

Section: Introductionmentioning

confidence: 99%

The potential value of serum chemerin in patients with breast cancer

Song

Zhu

Zhang

et al. 2021

Sci Rep

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Breast cancer (BC) is one of the most dangerous malignant diseases in females. However, the reliable serum biomarkers of BC still need to be explored. Chemerin levels have been found to be associated with different types of cancer. This study aimed to evaluate the role of serum chemerin as a biomarker of BC diagnosis, as well as the correlation between serum chemerin levels and clinicopathological features. The serum from 248 BC patients, 30 breast benign tumor patients, and 103 healthy controls were collected and serum chemerin levels were determined with enzyme-linked immunosorbent assay. We found that serum levels of chemerin in BC patients were higher than those in healthy control individuals (p < 0.05). The area under the ROC curve (AUC) for chemerin, CA15-3 and CEA was 0.703, 0.662 and 0.581, respectively, in distinguishing between breast cancer patients from healthy individuals, and the chemerin cutoff value was 100.327 ng/ml with a sensitivity of 56.60% and a specificity of 98.10%. The AUC for chemerin + CA15-3 was 0.822, which was higher than that for chemerin + CEA and CEA + CA15-3. Moreover, serum levels of chemerin were significantly associated with histologic grade, Ki67 expression, and menopausal status. However, no significant association was found between serum levels of chemerin and age, tumor size, metastase, ER status, PR status, and HER-2 status. Overall, our study suggested that the combination of chemerin with CA15-3 achieves relatively better diagnostic performance in the breast cancer. Elevated serum chemerin is associated with Ki67 expression levels and histologic grade.

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Reduced expression of chemerin is associated with poor clinical outcome in acute myeloid leukemia

Cited by 12 publications

References 35 publications

Mechanisms and Functions of Chemerin in Cancer: Potential Roles in Therapeutic Intervention

Mechanisms and Functions of Chemerin in Cancer: Potential Roles in Therapeutic Intervention

Chemerin and Cancer

The potential value of serum chemerin in patients with breast cancer

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