Reduced Expression of the Interferon‐Gamma Messenger RNA in IgG2 Deficiency

Kondo, Naomi; Inoue, Ryosuke; Kasahara, Kimiko; Fukao, Toshiyuki; Kaneko, Hideo; Tashita, Hideaki; Teramoto, Tamio

doi:10.1046/j.1365-3083.1997.d01-387.x

Cited by 21 publications

(13 citation statements)

References 6 publications

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“…The cytokine regulation of IgG2 production is still a largely ambiguous subject. Gamma interferon (IFN-␥) may have a role, as suggested in previous studies (9,12,14). However, we were unable to note any significant difference in IFN-␥ level between the mild and severe groups in our study.…”

Section: Discussioncontrasting

confidence: 49%

The Lower Serum Immunoglobulin G2 Level in Severe Cases than in Mild Cases of Pandemic H1N1 2009 Influenza Is Associated with Cytokine Dysregulation

Chan

Tse

et al. 2011

Clin Vaccine Immunol

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The majority of patients with pandemic influenza H1N1 2009 had mild illness, but some, including those with no risk factors for severe disease, may succumb to this infection. Besides viral factors such as the D222/225G substitution of the hemagglutinin, host factors such as IgG2 subclass deficiency recently was reported to be associated with severe disease in a cohort of Australian patients besides other known risk factors, including underlying chronic illness, extremes of age, and pregnancy. We conducted a case-control study of 38 Asian patients with respiratory failure due to severe pandemic influenza and compared the results to those for 36 mild cases. None had selective IgG2 deficiency, but the level of IgG2 subclass was significantly lower in the severe cases (3.55 g/liter versus 4.75 g/liter; P ‫؍‬ 0.002), whereas the levels of IgG1, IgG3, and IgG4 were not significantly different from those of the mild cases. Previous studies suggested that some IgHG2 and Fc␥RIIa genotypes were associated with IgG2 deficiency. The allelic frequency of the IgHG2 genotypes in our severe cases was not correlated with their levels of IgG2, while that of Fc␥RIIa was not significantly different from that of the general Han Chinese population (P ‫؍‬ 0.216). Only the overall cytokine/chemokine profile (P ‫؍‬ 0.029) and serum globulin level (P ‫؍‬ 0.005) were found to be independently associated with the IgG2 level by multivariate analysis. The lower IgG2 level in our severe group might be related to cytokine dysregulation rather than being a significant risk factor for severe pandemic influenza. The importance of this finding for therapeutic intervention will require further studies of larger cohorts of patients.

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Section: Discussioncontrasting

confidence: 49%

The Lower Serum Immunoglobulin G2 Level in Severe Cases than in Mild Cases of Pandemic H1N1 2009 Influenza Is Associated with Cytokine Dysregulation

Chan

Tse

et al. 2011

Clin Vaccine Immunol

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“…No relationship between anti‐ P. falciparum IgE and IgG1, and/or IgG3 levels was observed. IgG2 is known to be a Th1 subclass Ig‐dependent on IFN‐γ (29,30). According to recent evidences, IL4 significantly enhances the expression of ɛ, γ1, γ2, γ3 and γ4 germline gene transcript (GLT) and the secretion of the corresponding proteins.…”

Section: Discussionmentioning

confidence: 99%

Differential regulation of IgG subclasses and IgE antimalarial antibody responses in complicated and uncomplicated Plasmodium falciparum malaria

Tangteerawatana¹,

Montgomery

Perlmann

et al. 2007

Parasite Immunology

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The aim of this study was to assess the immunoglobulin (Ig)-subclass distribution of antimalarial antibody responses in 110 and 169 Thai patients with complicated and uncomplicated Plasmodium falciparum malaria, respectively. Antimalarial plasma IgG subclasses and IgE antibody levels against a crude malaria blood stages, and antigen preparation were determined using enzyme-linked immunosorbent assay (ELISA). On admission, the levels of anti-P. falciparum IgG1, IgG2 and IgG3 were significantly lower in patients with complicated malaria than uncomplicated malaria (IgG1, P < 0.0001; IgG2, P < 0.0001; IgG3, P < 0.0001). The levels of antimalarial IgE were slightly lower, but not statistically significant (P = 0.389) in the complicated malaria. After adjusting all antibody levels and age, anti-P. falciparum IgG3 levels remained significantly associated with complicated malaria. None of the other antibody concentrations showed statistically significant associations with complicated malaria. The anti-P. falciparum IgG3 levels were related to the IgG1 as well as IgG2 levels. A correlation between anti-P. falciparum IgG2 and IgE was observed in the complicated malaria group, and this may indicate their roles in the severity of disease. Our data suggest that anti-P. falciparum IgG3 is associated with a reduced risk of complicated malaria and that antimalarial Ig-subclasses are differently regulated in patients with complicated and uncomplicated malaria.

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“…Specific cytokine responses in the SPT − subjects involves IFNγ, IL‐6 and IL‐10 production at levels comparable to the SPT + group, together with very low levels of IL‐4 mRNA. It is pertinent to note in this context that IgG2 antibody production has been shown to be IFNγ dependent [ 24, 25].…”

Section: Discussionmentioning

confidence: 99%

Regulation of T‐helper cell responses to inhalant allergen during early childhood

Macaubas

Sly

Burton

et al. 1999

Clin Experimental Allergy

116

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Detailed analysis of cytokine responses in this very young age group have the potential to uncover subtle relationships between in vivo and in vitro allergen reactivity which may be less clear in adults, in whom T-cell response patterns are modified via chronic stimulation. The present findings which suggest potentially important roles for IL-9 and IL-10 in the early phase of allergic disease, may be one such example.

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Reduced Expression of the Interferon‐Gamma Messenger RNA in IgG2 Deficiency

Cited by 21 publications

References 6 publications

The Lower Serum Immunoglobulin G2 Level in Severe Cases than in Mild Cases of Pandemic H1N1 2009 Influenza Is Associated with Cytokine Dysregulation

The Lower Serum Immunoglobulin G2 Level in Severe Cases than in Mild Cases of Pandemic H1N1 2009 Influenza Is Associated with Cytokine Dysregulation

Differential regulation of IgG subclasses and IgE antimalarial antibody responses in complicated and uncomplicated Plasmodium falciparum malaria

Regulation of T‐helper cell responses to inhalant allergen during early childhood

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