Reduced expression of ΔΝp63α in cervical squamous cell carcinoma

Ying, Zhe; Xu, Qianqian; Ling, Bin; Xiao, Weihua; Liu, Peishu

doi:10.25011/cim.v34i3.15192

Cited by 14 publications

(11 citation statements)

References 33 publications

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“…It has been previously shown that upregulation of PCNA is closely associated with hrHPV and progressive CIN, but does not predict outcome in cervical cancer 135. P63, which is a member of the p53 gene family, is expressed in the basal and parabasal cells of mature cervical, vaginal, and vulval squamous epithelium, and also in cervical reserve cells at the transformation zone 113,136. It has been shown that MIB-1 may be a useful marker for identification of low-grade CIN lesion with high proliferative index 137.…”

Section: Biomarkers Used In Hiv-associated Cervical Cancer Diagnosis/mentioning

confidence: 99%

Biomarkers of HIV-associated Cancer

et al. 2014

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Cancer biomarkers have provided great opportunities for improving the management of cancer patients by enhancing the efficiency of early detection, diagnosis, and efficacy of treatment. Every cell type has a unique molecular signature, referred to as biomarkers, which are identifiable characteristics such as levels or activities of a myriad of genes, proteins, or other molecular features. Biomarkers can facilitate the molecular definition of cancer, provide information about the course of cancer, and predict response to chemotherapy. They offer the hope of early detection as well as tracking disease progression and recurrence. Current progress in the characterization of molecular genetics of HIV-associated cancers may form the basis for improved patient stratification and future targeted or individualized therapies. Biomarker use for cancer staging and personalization of therapy at the time of diagnosis could improve patient care. This review focuses on the relevance of biomarkers in the most common HIV-associated malignancies, namely, Kaposi sarcoma, non-Hodgkin’s lymphoma, and invasive cervical cancer.

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Section: Biomarkers Used In Hiv-associated Cervical Cancer Diagnosis/mentioning

confidence: 99%

Biomarkers of HIV-associated Cancer

et al. 2014

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“…It has been previously reported that the abnormal epithelial differentiation of the cervix contributes to the tumorigenesis of cervical cancer [13,33]. p63, notch1, microRNAs, and ITCH are considered to be the most important regulators of differentiation [12,[33][34][35].…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, we found that p63 expression was decreased or absent in SCC [13]. In this study, we aim to explore the subcellular localization and expression of ITCH and it alternate substrate, LATS1, in the different stages and grades of cervical dysplasia and SCC, which will illustrate the functions of ITCH and LATS1 during the malignant transformation of cervical cells.…”

mentioning

confidence: 96%

“…Recently, pathologists combined CIN II and CIN III into a single grade, CIN II/III. The causes of cervical cancer are closely related to the persistent infection of high-risk human papillomavirus (HR-HPV) [2,3]; however, other factors, such as chronic inflammation [4][5][6][7], abnormal gene expression [8], ubiquitin-mediated degradation disorders [9][10][11] and aberrant differentiation, may also be involved [12,13]. To date, the exact molecular basis required for normal cervical squamous epithelial cells to advance to neoplasia, and then invasive carcinoma, has not been fully described.…”

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confidence: 99%

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Up-regulation of ITCH is associated with down-regulation of LATS1 during tumorigenesis and progression of cervical squamous cell carcinoma

Ying¹,

Feng²,

Cheng³

et al. 2014

CIM

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Purpose: The molecular basis for the normal cervical squamous epithelium advance to cervical intraepithelial neoplasia (CIN I, CIN II, CIN III) and ultimately to invasive carcinoma has not yet been defined. We explored the abnormal expression of ITCH (AIP4) and its degrading substrate Large Tumor Suppressor 1 (LATS1) in CINs and cervical cancers, which might disrupt the normal differentiation of the cervical epithelia and contribute to the tumorigenesis of the cervix. Methods: A series of 110 samples, comprising 24 cases of normal cervical tissues, 20 cases of CIN I, 26 cases of CIN II/ III and 40 cases of squamous cancer of the cervix (SCC) were used for analysis. The expression of ITCH and LATS1 was assessed in the tissues by immunohistochemistry, and statistically analyzed by SPSS13.0. Results: The increased nuclear and cytoplasmic expression levels of ITCH and the low membrane expression of LATS1 were strongly associated with the malignant transformation of the cervical epithelium and the histological progression of SCC. Moreover, the high nuclear and cytoplasmic expression levels of ITCH were significantly correlated with clinical stage (P=0.036, P=0.003, respectively) and tumor size (P=0.046,P=0.039, respectively); the low membrane expression of LATS1 was significantly correlated with clinical stage (P=0.036)and tumor size (P=0.023). Both the nuclear and cytoplasmic expression levels of ITCH were inversely associated with the membrane expression of LATS1 in cervical tissues (P

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“…Once cell cycle arrest occurs, most basal cells will enter into terminal di erentiation and die by apoptosis [25]. In epidermal keratinocytes, terminal di erentiation and corni cation is a specialized form of apoptosis [26][27]; thus, the disturbance of normal corni cation through the loss of the ability to di erentiate can lead to ma- lignant squamous cell transformation [28][29]. In this study, GRIM-19 was found to be predominantly expressed in the cytoplasm of the middle layer of the cervix and also in the basal layer, although it was completely absent in the surface layer of the cervix.…”

Section: Grim-19 Expression In Cervical Intraepithelial Neoplasias Anmentioning

confidence: 99%

Decreased expression of GRIM-19 and its association with high-risk HPV infection in cervical squamous intraepithelial neoplasias and cancer

Cheng¹,

Zhang²,

Ying³

et al. 2014

CIM

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Purpose: GRIM-19 has been shown to be down-regulated in cervical cancers. This study investigated the expression of GRIM-19 in cervical intra-epithelial neoplasias and its association with high-risk human papillomavirus (HR-HPV) infection. Methods: The expression of GRIM-19 was assessed in cervical exfoliated cells and cervical intra-epithelial neoplasia tissues by immunohistochemistry, and the level of GRIM-19 was also evaluated by Western blotting using cervical exfoliated cells. HR-HPV infection of cervical exfoliated cells was detected by HC II. Results: GRIM-19 is predominantly expressed in the cytoplasm of the middle layer of normal cervical epithelial cells, whereas the surface layer cells of the normal cervix showed no GRIM-19 expression. The expression of GRIM-19 gradually decreased from atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) to squamous cell carcinoma (SCC); a pattern which was also observed in cervical intra-epithelial neoplasias tissues. The reduced expression of GRIM-19 was correlated with HR-HPV infection. Conclusion: GRIM-19 may regulate the differentiation of normal cervical tissue, and a decrease in GRIM-19 may be the result of HR-HPV infection, which in turn leads to the malignant transformation of the cells.

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Reduced expression of ΔΝp63α in cervical squamous cell carcinoma

Cited by 14 publications

References 33 publications

Biomarkers of HIV-associated Cancer

Biomarkers of HIV-associated Cancer

Up-regulation of ITCH is associated with down-regulation of LATS1 during tumorigenesis and progression of cervical squamous cell carcinoma

Decreased expression of GRIM-19 and its association with high-risk HPV infection in cervical squamous intraepithelial neoplasias and cancer

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