Reduced Fat Oxidation During Exercise in Post-Menopausal Overweight-Obese Women with Higher Lipid Accumulation Product Index

Abstract

Background and Aims The main aim of this study was to analyze how the lipid accumulation affects the whole-body fat oxidation over a range of intensities during a submaximal incremental exercise test in post-menopausal overweight-obese women. Patients and Methods The maximal fat oxidation (MFO), the intensity where the MFO occurs (FatMax), fat oxidation were measured over a range of intensities during a submaximal incremental exercise test through indirect calorimetry in 60 postmenopausal overweight-obese women (aged>49 years; body mass index 28.0 to 39.0 kg/m²). The metabolic profile of participants was evaluated and the LAP index was calculated (waist-58×triglycerides [mmol/L]). A cutoff point of 34.5 was adopted and participant were designed as low LAP index (n=30) or high LAP index (n=30). Results During submaximal exercise postmenopausal overweight-obese women with low LAP index showed a higher fat oxidation at 50% (0.53±0.05 vs. 0.45±0.12 g/min; p=0.01), 60% (0.40±0.06 vs. 0.31±0.16 g/min; p=0.02) and 70% (0.34±0.08 vs. 0.25±0.15 g/min; p=0.03) of VO2Peak than those with high LAP index. No significant difference was observed in carbohydrate oxidation between groups (p>0.05) during exercise. Moreover, a significant difference in absolute MFO (p=0.018), MFO relative to free fat mass (p=0.043) and FatMax (p=0.002) was identified. Conclusion Postmenopausal overweight-obese women who showed unhealthy metabolic phenotype evaluated through LAP index presented low fat oxidation during a submaximal incremental exercise.

Effects of an Indoor Cycling Program on Cardiometabolic Factors in Women with Obesity vs. Normal Body Weight

“…Our results further indicated that cardiovascular risk parameters were related to the occurrence of an abnormal LAP index, for which the cutoff point was 34.2 cm × mmol/L, above which, the risk of metabolic syndrome is increased [28]. In line with previous literature [29], our results indicate a significantly greater LAP index in the OW group compared to that in the NW group both before and after the intervention, indicating an unhealthy metabolic phenotype for women with obesity. However, women with obesity showed a decrease in LAP in response to IC training (Table 3).…”

Effects of Regular Exercise and Intermittent Fasting on Neurotransmitters, Inflammation, Oxidative Stress, and Brain-Derived Neurotrophic Factor in Cortex of Ovariectomized Rats

“…The American Heart Association and the American College of Sports Medicine both advise older women to engage in exercise because it is a low-cost intervention that has numerous advantages for women's health after menopause [57]. In their study of postmenopausal overweight/obese women's whole-body fat oxidation during acute treadmill activity, Stein and colleagues [58] discovered an antagonistic association between metabolic health and the capacity to burn fat in response to aerobic exercise. This shows that higher metabolic rigidity is linked to increased lipid accumulation, which results in increased body fat and visceral fat distribution [59].…”

Hederagenin Exerts Potential Antilipemic Effect via p38MAPK Pathway in Oleic Acid-induced HepG2 cells and in Hyperlipidemic Rats

“…In the meantime, previous studies had shown that hederagenin could effectively treat tumors through anti-oxidation (Kim et al 2017a) and antiinflammation (Lee et al 2015). Lowering blood lipids is often closely related to properties of antioxidation (Stein et al 2020 (Canesi et al 2019). However, there are no studies have reported that hederagenin can decrease blood lipid.…”