Reduced Fertility and Fecundity among Patients with Bipolar I Disorder and Schizophrenia in Egypt

Mansour, Hader; Kandil, Kareem; Wood, Joel; Fathi, Warda; Elassy, Mai; Ibrahim, Ibtihal; Salah, Hala; Yassin, Amal; Elsayed, Hanan; Tobar, Salwa; El-Boraie, Hala; Eissa, Ahmed; Elhadidy, Mohamed; Ibrahim, Nahed E.; El-Bahaei, Wafaa; Nimgaonkar, Vishwajit L.

doi:10.4306/pi.2011.8.3.214

Cited by 11 publications

(6 citation statements)

References 37 publications

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“…This finding supports the robust evidence in the literature, which suggests that schizophrenia strongly aggregates in families of schizophrenia probands more than the general population. 18,24 It also supports the views of previous authors that the risk in relatives is a function of the degree of genetic relatedness to the probands and the comparison group. 24,25 Thus, the highest risk was amongst the FDRs followed by second- and third-degree relatives, respectively.…”

Section: Discussionsupporting

confidence: 87%

Morbid risk of schizophrenia amongst relatives of schizophrenia probands: A family-controlled study

et al. 2018

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IntroductionThere is a dearth of data on heritability of schizophrenia in Africa. The few African studies that addressed familial psychiatric morbidity in schizophrenia involved relatively small sample sizes and addressed psychiatric morbidity only in first-degree relatives. The present study sought to improve upon the methodology of previous African studies, and widen the scope to second- and third-degree relatives with a view to enriching the field of genetic epidemiology in Africa.MethodsThis study elicited information on the morbid risk of schizophrenia amongst 5259 relatives of schizophrenia probands (n = 138) and 6734 relatives of healthy controls (n = 138) through direct interview of patients, available relatives of patients and controls. Diagnosis of probands was confirmed using Mini International Neuropsychiatric Interview. Through a direct interview of 138 patients and their available relatives, a family history approach using the Family Interview for Genetic Studies was utilised to obtain information on the morbid risk for all relatives that could be recalled. The same approach was utilised for the interview of the controls (aged 45 years and above) and their relatives. Morbid risk estimates were calculated using the Weinberg shorter method.ResultsMorbid risk for schizophrenia in the first-, second- and third-degree relatives of schizophrenia probands was 10.9% (95% confidence interval [CI] = 10.6–11.2), 4.2% (95% CI = 4.1–4.3) and 3.9% (95% CI = 3.6–4.2), respectively, compared with 2.6% (95% CI = 2.5–2.7), 1.6% (95% CI = 1.5–1.7) and 1.5% (95% CI = 1.4–1.6), respectively, of the healthy control group.ConclusionThe findings support the widely noted impression that schizophrenia significantly aggregates in families of schizophrenia probands more than healthy controls.

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Section: Discussionsupporting

confidence: 87%

Morbid risk of schizophrenia amongst relatives of schizophrenia probands: A family-controlled study

et al. 2018

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“…[ 44 ] Studies from other countries have also shown lesser number of conceptions and live children for women with BD compared to general populations and major depressive disorder. [ 39 45 ] However, when compared to patients of schizophrenia, findings are inconsistent, with some studies showing lesser number of conceptions and live children for women with BD,[ 39 ] whereas others have reported comparable rates. [ 45 ]…”

Section: Bipolar Affective Disorder and Procreationmentioning

confidence: 99%

“…[ 39 45 ] However, when compared to patients of schizophrenia, findings are inconsistent, with some studies showing lesser number of conceptions and live children for women with BD,[ 39 ] whereas others have reported comparable rates. [ 45 ]…”

Section: Bipolar Affective Disorder and Procreationmentioning

confidence: 99%

Bipolar affective disorder and its impact on various aspects of marital relationship

2017

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Bipolar disorder (BD) is a severe mental disorder, which not only has negative consequences on the life of the patient, but also affects the immediate family members. As it often starts early in life, patients who get married often suffer from many negative consequences in their marital life due to the illness. This review focuses on studies which have evaluated marital rates, rate of marital failure, divorce, infertility, and procreation among patients with BD. In addition, this review evaluates the existing literature pertaining to marital adjustment, marital satisfaction, sexual dysfunction, and sexual satisfaction among patients with BD and their partners/spouses. Data suggest that very high proportion of patients with BD get married and marital rates are higher for patients with BD, when compared with those suffering from schizophrenia. In terms of divorce rates, studies suggest that patients with BD have higher rates of divorce. In terms of fertility rates, studies suggest that compared to those without the illness, the fertility rates among patients with BD are lower. In terms of marital adjustment, results are mixed with some studies suggesting poorer marital adjustment among patients and their spouses too. In terms of sexual dysfunction, studies suggest the presence of sexual dysfunction among one-third to half of the patients receiving lithium. To conclude, this review suggests that patients with BD experience multiple negative marital and sexual consequences.

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“…An interesting, though not unexpected, observation is that patients with schizophrenia have significantly fewer children compared to the general population [17, 18, 19]. In theory, this should be generating an enormous negative selective pressure quickly removing risk alleles from the population; however, the disease maintains a relatively high heritability and prevalence at ∼1%.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Genetics of Schizophrenia

Avramopoulos

2018

Complex Psychiatry

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The last decade brought tremendous progress in the field of schizophrenia genetics. As a result of extensive collaborations and multiple technological advances, we now recognize many types of genetic variants that increase the risk. These include large copy number variants, rare coding inherited and de novο variants, and over 100 loci harboring common risk variants. While the type and contribution to the risk vary among genetic variants, there is concordance in the functions of genes they implicate, such as those whose RNA binds the fragile X-related protein FMRP and members of the activity-regulated cytoskeletal complex involved in learning and memory. Gene expression studies add important information on the biology of the disease and recapitulate the same functional gene groups. Studies of alternative phenotypes help us widen our understanding of the genetic architecture of mental function and dysfunction, how diseases overlap not only with each other but also with non-disease phenotypes. The challenge is to apply this new knowledge to prevention and treatment and help patients. The data generated so far and emerging technologies, including new methods in cell engineering, offer significant promise that in the next decade we will unlock the translational potential of these significant discoveries.

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Reduced Fertility and Fecundity among Patients with Bipolar I Disorder and Schizophrenia in Egypt

Cited by 11 publications

References 37 publications

Morbid risk of schizophrenia amongst relatives of schizophrenia probands: A family-controlled study

Morbid risk of schizophrenia amongst relatives of schizophrenia probands: A family-controlled study

Bipolar affective disorder and its impact on various aspects of marital relationship

Recent Advances in the Genetics of Schizophrenia

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