Reduced fibre size, capillary supply and mitochondrial activity in constitutional thinness' skeletal muscle

Galusca, Bogdan; Verney, Julien; Meugnier, Emmanuelle; Ling, Yiin; Édouard, Pascal; Féasson, Léonard; Ravelojaona, Marion; Vidal, Hubert; Estour, Bruno; Germain, Natacha

doi:10.1111/apha.13097

Cited by 19 publications

(44 citation statements)

References 50 publications

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“…CT seems then to be a natural state of underweight leading to a high self-dissatisfaction and whose causes remain unclear. While absolute resting energy expenditure was found lower (7,8,10) or similar (16)(17)(18) in CT individuals v. normal-weight control subjects, resting energy expenditure:fat-free mass ratio was found higher in CT v. control subjects in some studies (7,18) but not significantly higher in some other studies (10,17,19) . Other evidence seems to indicate a more pronounced brown fat activity in CT (20) .…”

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confidence: 72%

“…Consideration of other main parameters in individuals with CT Areas of study Schneider et al (32) Females Scalfi et al (16) Females: CT: n 7; 28•6 (SD Hinney et al (35) Females Slof et al (37) Females: Bosy-Westphal et al (38) CT ( Germain et al (9) Females: CT: n 10; 20 Marra et al (17) Females: CT: n 20; 22 Fernández-García et al (24) Females Germain et al (21) Females Marra et al (25) Females Galusca et al (22) Females Pasanisi et al (20) Females Paschalis et al (43) Females (50) and EDE (51) Germain et al (27) Females: CT: n 10; 20•6 (SD (53) , and Body Shape Questionnaire (47) - Galusca et al (19) Females Florent et al (45) Females (48) ; DEBQ, Dutch Eating Behaviour Questionnaire; EDE, Eating Disorder Examination Questionnaire; IGF-1, insulin-like growth factor-1; FT 3 , free triiodothyronine; MOSPA, Monica Optional Study of Physical Activity (52) . * SCOFF questions, Do you make yourself sick because you feel uncomfortably full?…”

Section: Consideration Of the Absence Of Eating Disorders In Individumentioning

confidence: 99%

“…Of the thirty-five studies selected in the systematic review, twenty-six (7)(8)(9)(10)(11)16,17,(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)32,33,36,37,40,41,43,45,46) enrolled females exclusively, three (18,34,39) enrolled males exclusively and six (30,31,35,38,42,44) enrolled both females and males (Table 1). Of these thirty-five studies, thirty-two (7)(8)(9)(10)(11)(16)(17)(18)(19)(20)(21)(22)(23)(24)…”

Section: Population Characteristicsmentioning

confidence: 99%

“…Other evidence seems to indicate a more pronounced brown fat activity in CT (20) . Despite an apparently similar energy intake (quantitatively as well as qualitatively) as normal-weight people (5,7,9,10,19) , specific physiological control of appetite has been suggested in individuals with CT (9)(10)(11)(21)(22)(23) , with, for instance, an earlier and higher satiety onset during meals leading to reduced but more frequent intakes (more in-between meals snacking) (10) . CT subjects present no eating disorder-related traits and even have lower food restrictive behaviours compared with normal-weight people (8,10) .…”

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confidence: 99%

“…CT subjects present no eating disorder-related traits and even have lower food restrictive behaviours compared with normal-weight people (8,10) . Despite their low BMI, they present a non-blunted fat mass (FM) percentage (7,8,10,11,17,19,(23)(24)(25)(26)(27) . However, CT people display impairments in their bone quality: small bone sizes, low bone mass, low calculated breaking strength (28) and low bone mineral density (19,24,26,28) , but, however, apparent normal bone turnover (28) .…”

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confidence: 99%

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Definition and diagnosis of constitutional thinness: a systematic review

et al. 2020

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The existing literature about the definition and diagnostic criteria of constitutional thinness (CT) appears equivocal. The present work systematically reviewed the criteria used in the diagnosis of adult individuals with CT (PROSPERO registration number: CRD42019138236). Five electronic bibliographic databases were searched between December 2018 and November 2019: MEDLINE, Embase, CENTRAL (Cochrane Library), Google Scholar and Clinical Trials. Search terms were combined with Medical Subject Headings terms. The search strategy included any clinical trials that enrolled adults with CT. Studies were systematically excluded if the state of thinness was not due to a well-identified constitutional origin. From the 689 references after duplicate removal, 199 studies were excluded based on title and 164 based on abstract. According to the inclusion and exclusion criteria, 291 other studies were removed. Finally, thirty-five studies remained at the end of the process. The analysis of these studies showed high heterogeneity in the diagnostic criteria of CT. A real need emerged to adopt a common terminology and to systematically exclude potential non-constitutional origins of thinness such as eating disorders, associated pathology or over-exercising, with validated tools. Weight history, physiological menses and weight gain resistance are also important criteria to consider. The present systematic review revealed that our medical and scientific approaches of CT need to be harmonised in terms of terminology and diagnostic criteria. Although further studies are needed, we finally proposed recommendations and a decision tree to help in the recognition and diagnosis of CT.

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confidence: 72%

Section: Consideration Of the Absence Of Eating Disorders In Individumentioning

confidence: 99%

Section: Population Characteristicsmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Definition and diagnosis of constitutional thinness: a systematic review

et al. 2020

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Resistance to lean mass gain in constitutional thinness in free‐living conditions is not overpassed by overfeeding

Ling

Galusca

Martin

et al. 2020

J cachexia sarcopenia muscle

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Background Constitutional thinness (CT), a non-malnourished underweight state with no eating disorders, is characterized by weight gain resistance to high fat diet. Data issued from muscle biopsies suggested blunted anabolic mechanisms in free-living state. Weight and metabolic responses to protein caloric supplementation has not been yet explored in CT. Methods A 2 week overfeeding (additional 600 kcal, 30 g protein, 72 g carbohydrate, and 21 g fat) was performed to compare two groups of CTs (12 women and 11 men) to normal-weight controls (12 women and 10 men). Bodyweight, food intake, energy expenditure, body composition, nitrogen balance, appetite hormones profiles, and urine metabolome were monitored before and after overfeeding. Results Before overfeeding, positive energy gap was found in both CT genders (309 ± 370 kcal in CT-F and 332 ± 709 kcal in CT-M) associated with higher relative protein intake per kilo (1.74 ± 0.32 g/kg/day in CT-F vs. 1.16 ± 0.23 in C-F,

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Proteomics reveals unique plasma signatures in constitutional thinness

Cominetti

Galindo

Corthésy

et al. 2022

Proteomics Clinical Apps

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Purpose: Studying the plasma proteome of control versus constitutionally thin (CT) individuals, exposed to overfeeding, may give insights into weight-gain management, providing relevant information to the clinical entity of weight-gain resistant CT, and discovering new markers for the condition.Experimental Design: Untargeted protein relative quantification of 63 CT and normalweight individuals was obtained in blood plasma at baseline, during and after an overfeeding challenge using mass spectrometry-based proteomics. Results:The plasma proteome of CT subjects presented limited specificity with respect to controls at baseline. Yet, CT showed lower levels of inflammatory C-reactive protein and larger levels of protective insulin-like growth factor-binding protein 2. Differences were more marked during and after overfeeding. CT plasma proteome showed larger magnitude and significance in response, suggesting enhanced "resilience" and more rapid adaptation to changes. Four proteins behaved similarly between CT and controls, while five were regulated in opposite fashion. Ten proteins were differential during overfeeding in CT only (including increased fatty acid-binding protein and glyceraldehyde-3-phosphate dehydrogenase, and decreased apolipoprotein C-II and transferrin receptor protein 1). Conclusions and Clinical Relevance:This first proteomic profiling of a CT cohort reveals different plasma proteomes between CT subjects and controls in a longitudinal clinical trial. Our molecular observations further support that the resistance to weight gain in CT subjects appears predominantly biological.

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Reduced fibre size, capillary supply and mitochondrial activity in constitutional thinness' skeletal muscle

Cited by 19 publications

References 50 publications

Definition and diagnosis of constitutional thinness: a systematic review

Definition and diagnosis of constitutional thinness: a systematic review

Resistance to lean mass gain in constitutional thinness in free‐living conditions is not overpassed by overfeeding

Proteomics reveals unique plasma signatures in constitutional thinness

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