Reduced fibroblast growth factor 21 and β-Klotho secretion in untreated congenital isolated GH deficiency

Oliveira-Santos, Alécia A; Salvatori, Roberto; Bueno, Ana Carolina; Nogueira, Mônica Cristina; Campos, Viviane C.; Melo, Manuela A; Oliveira, Carla R. P.; Barros-Oliveira, Cynthia S; Marinho, Cindi G.; Damascena, Nicole Prata; Santos, Elenilde G.; Melo, Enaldo Vieira de; Paula, Francisco José Albuquerque de; Castro, Margaret de; Aguiar‐Oliveira, Manuel H.

doi:10.1007/s12020-021-02700-6

Cited by 1 publication

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“…These FGF21 and β-Klotho levels may not have been significantly influenced by the test meal but rather reflected their spontaneous morning secretion. This suggests that lower FGF21 and β-Klotho secretion is compatible with healthy status and longevity ( 60 ). Together, these “enteroendocrine” connections may result in a favourable outcome in terms of environmental adaptation, ensuring adequate food intake, and may confer metabolic and vascular benefits ( 59 , 60 ).…”

Section: Body Functions In Itabaianinha Syndromementioning

confidence: 99%

“…This suggests that lower FGF21 and β-Klotho secretion is compatible with healthy status and longevity ( 60 ). Together, these “enteroendocrine” connections may result in a favourable outcome in terms of environmental adaptation, ensuring adequate food intake, and may confer metabolic and vascular benefits ( 59 , 60 ).…”

Section: Body Functions In Itabaianinha Syndromementioning

confidence: 99%

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The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome

Aguiar‐Oliveira¹,

Salvatori²

2022

Archives of Endocrinology and Metabolism

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In the late 19 th century, José Dantas de Souza Leite, a physician born in Sergipe, published the first detailed clinical description of acromegaly under the guidance of the French neurologist Pierre Marie. In 2014, the Brazilian Society of Endocrinology and Metabolism created the "José Dantas de Souza Leite Award" , which is granted every two years to a Brazilian researcher who has contributed to the development of endocrinology. In 2022, the award was given to another physician from Sergipe, Manuel Hermínio de Aguiar Oliveira, from the Federal University of Sergipe for the description of "Itabaianinha syndrome" in a cohort of individuals with isolated GH deficiency due to a homozygous inactivating mutation in the GH-releasing hormone receptor gene. This research, which was carried out over almost 30 years, was performed in partnership with Roberto Salvatori from Johns Hopkins University and in collaboration with other researchers around the world. This review article tells the story of Souza Leite, some milestones in the history of GH, and summarizes the description of Itabaianinha syndrome.

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Section: Body Functions In Itabaianinha Syndromementioning

confidence: 99%