Reduced Fine API Agglomeration After Dry Coating for Enhanced Blend Uniformity and Processability of Low Drug Loaded Blends

Crystal and Particle Engineering – An Indispensable Tool for Developing and Manufacturing Quality Pharmaceutical Products

“…It was demonstrated that even at a very low API loading, amounting to an extremely low silica fraction in the blend, dry coating of the API greatly influenced the flowability of multi-component blends having all fine sized excipients. It is important to note that without dry coating, the blend flowability was poor [9]. The analysis of surface hydrophobicity and agglomerate reduction for various coating formulations that included hydrophobic or hydrophobic silica, confirmed the significant role that API agglomeration (or lack of it) could play on tablet dissolution, negating even the adverse impact of increased drug hydrophobicity with R972P coating.…”

“…Kim et al leveraged the advantages of reduced powder cohesion and agglomeration due to dry coating for the purpose of augmenting the design space for direct compression (DC) tableting at very low drug loading of cohesive fine APIs [9]. Their work elucidated the synergistic structural changes in the blend properties, arising from the silica transfer induced by mixing dynamics, and their impact on the performance of the tablets.…”