Reduced flanker P300 prospectively predicts increases in depression in female adolescents

Santopetro, Nicholas J.; Kallen, Alexander M.; Threadgill, A. Hunter; Hajcak, Greg

doi:10.1016/j.biopsycho.2020.107967

Cited by 22 publications

(29 citation statements)

References 47 publications

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“…Altogether, the present results suggest that a reduced P300 to flanker stimuli may be used to identify currently depressed adults who are at risk for worse prognosis. A reduced P300 in the flankers task is associated with a current depression diagnosis (Klawohn, Burani, et al., 2020) and can prospectively predict future symptom severity both in youth (Santopetro et al., 2020) and, as the current study demonstrated, among adults already affected with depression. Thus, this neural biomarker is a reasonable target for novel interventions, which would provide insight into whether intervention‐related changes in the P300 can impact clinical course and outcomes.…”

Section: Discussionmentioning

confidence: 58%

“…Utilizing both flanker P300 and self‐report information together can potentially lead to more accurate predictions in future depressive symptoms. For example, we recently demonstrated in a large female adolescent sample ( n = 199) that flanker P300 increased the ability to predict increases in depression symptoms two years later (Santopetro et al., 2020). In the context of the current study, these data indicate that reduced P300 in the flankers task may predict both clinical and non‐clinical changes in depression.…”

Section: Discussionmentioning

confidence: 99%

“…Another advantage of using ERPs in psychopathology research is the potential to prospectively predict changes in symptomatology or new onsets/episodes of disorders (Hajcak et al., 2019). In combination with self‐report measures, ERPs have been shown to independently predict depression outcomes (e.g., Burani et al., 2019; Mumtaz et al., 2015; Santopetro et al., 2020). To date, there has been relatively little research to examine whether the P300 can serve as a biomarker with prognostic utility within adult depression.…”

Section: Introductionmentioning

confidence: 99%

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A reduced P300 prospectively predicts increased depressive severity in adults with clinical depression

et al. 2021

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Neurocognitive impairments commonly observed in depressive disorders are thought to be reflected in reduced P300 amplitudes. To date, depression‐related P300 amplitude reduction has mostly been demonstrated cross‐sectionally, while its clinical implication for the course of depression remains largely unclear. Moreover, the relationship between P300 and specific clinical characteristics of depression is uncertain. To shed light on the functional significance of the P300 in depression, we examined whether initial P300 amplitude prospectively predicted changes in depressive symptoms among a community sample of 58 adults (mean age = 38.86 years old, 81% female) with a current depressive disorder. This sample was assessed at two‐time points, separated by approximately nine months (range = 6.6–15.9). At the initial visit, participants completed clinical interviews, self‐report measures, and a flanker task, while EEG was recorded to derive P300 amplitude. At the follow‐up visit, participants again completed the same clinical interviews and self‐report measures. Results indicated that a reduced P300 amplitude at the initial visit was associated with higher total depressive symptoms at follow‐up, even after controlling for initial depressive symptoms. These data indicate the potential clinical utility for the P300 as a neural marker of disease course among adults with a current depressive disorder. Future research may target P300 in interventions to determine whether depression‐related outcomes can be improved.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A reduced P300 prospectively predicts increased depressive severity in adults with clinical depression

et al. 2021

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“…Participants in the current study completed self-report questionnaires on their current depression and anxiety symptoms, as well as a flanker task while EEG was recorded. Based on the inconsistent findings observed in the N200 and depression literature as well as the results from a recent prospective study in a large adolescent sample of female participants (Santopetro et al, 2020), we predicted that only flanker P300 amplitude would be associated with current depressive symptoms, such that individuals with reduced flanker P300 will exhibit heightened depressive symptoms.…”

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confidence: 98%

“…In one study, Houston and colleagues (2003) observed reductions in P300 amplitude in participants with a history of depression in a large sample of female adolescents that completed a complex visual oddball task. More recently, reductions in baseline P300 amplitude, derived from the flanker task, predicted increases in depressive symptoms over a two-year period in a large sample of female adolescents (Santopetro et al, 2020). Additionally, Santopetro and colleagues found no relationships between baseline flanker P300 amplitude with baseline or two-year anxiety symptoms-suggesting specificity of the P300-depression association.…”

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confidence: 99%

Blunted Flanker P300 Demonstrates Specificity to Depressive Symptoms in Females during Adolescence

Santopetro

Kallen

Threadgill

et al. 2021

Res Child Adolesc Psychopathol

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Recent research suggests that depressive disorders in adults are characterized by reductions in flanker P300 amplitude, and that a reduced flanker P300 may also predict worst depressive trajectories over time. The current study extended this work to adolescence-and to evaluate the specificity of the relationship between flanker P300 to depressive symptoms versus anxiety symptoms, and whether the association between flanker P300 and depressive symptoms was moderated by biological sex. To this end, P300 amplitude, depression, anxiety, and sex were assessed in a large sample of 619 adolescents aged 11 to 14. Participants completed a speeded response flanker task while EEG was recorded, as well as self-reported measures of current depression and anxiety symptoms. Reduced P300 amplitude was related to both heightened depression and anxiety symptoms in zero-order correlations. Regression-based analyses suggest that reduced P300 was uniquely related to depressive symptoms. Furthermore, this negative association between P300 and depression was apparent in female adolescents, but not male adolescents. In sum, the current study suggests that flanker P300 amplitude may potentially serve as a neural marker specific to depression in females during adolescence.

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Associations between disordered eating, internalizing symptoms, and behavioral and neural correlates of response inhibition in preadolescence

Thomas,

Jones,

Williams

et al. 2024

Developmental Psychobiology

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Response inhibition difficulties are reported in individuals with eating disorders (EDs), anxiety, and depression. Although ED symptoms and internalizing symptoms co‐occur in preadolescence, there is limited research examining associations between these symptoms and response inhibition in this age group. This study is the first to investigate the associations between behavioral and neural markers of response inhibition, disordered eating (DE), and internalizing symptoms in a community sample of preadolescents. Forty‐eight children (M age = 10.95 years, 56.3% male) completed a Go/NoGo task, whereas electroencephalography was recorded. Self‐report measures of DE and internalizing symptoms were collected. Higher levels of anxiety and depression were associated with neural markers of suboptimal response inhibition (attenuated P3NoGo amplitudes) in preadolescence. In contrast, higher levels of depression were associated with greater response inhibition at a behavioral level. These findings suggest internalizing symptoms in preadolescence are associated with P3‐indexed difficulties in evaluation and monitoring, but these are not sufficient to disrupt behavioral performance on a response inhibition task. This pattern may reflect engagement of compensatory processes to support task performance. DE was not significantly associated with response inhibition, suggesting that difficulties in response inhibition may only be reliably observed in more chronic and severe DE and ED presentations.

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Reduced flanker P300 prospectively predicts increases in depression in female adolescents

Cited by 22 publications

References 47 publications

A reduced P300 prospectively predicts increased depressive severity in adults with clinical depression

A reduced P300 prospectively predicts increased depressive severity in adults with clinical depression

Blunted Flanker P300 Demonstrates Specificity to Depressive Symptoms in Females during Adolescence

Associations between disordered eating, internalizing symptoms, and behavioral and neural correlates of response inhibition in preadolescence

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