Reduced flow-mediated vasodilation as a marker for cardiovascular complications in lupus patients

Kiss, Emese; Soltész, Pál; Dér, Henriett; Kocsis, Zsolt; Tarr, Tünde; Bhattoa, Harjit Pal; Shoenfeld, Yehuda; Szegedi, Gyula

doi:10.1016/j.jaut.2006.09.008

Cited by 78 publications

(57 citation statements)

References 35 publications

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“…Consistent with this notion, other chronic inflammatory immune disorders have been identified as independent risk factors for CVD. Recent studies have demonstrated that patients with psoriasis arthritis (PsA) [28], RA [16][17][18] and SLE [19][20][21], have impaired endothelial function reflecting an early stage of atherosclerosis [29,30]. The endothelial dysfunction seems to appear prior to any overt CVD and in the absence of classic cardiovascular risk factors, indicating that systemic inflammatory, a key feature in PsA, RA and SLE, may play a pivotal role in the increased prevalence of cardiovascular complications in these patients.…”

Section: Discussionmentioning

confidence: 99%

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Endothelial Function and Inflammatory Activity in Patients with Recent Onset of Severe Plaque Psoriasis

Mallbris

Pernowb²,

Ståhle³

2008

TODJ

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Abstract:Background: Psoriasis is associated with premature atherosclerosis and cardiovascular co-morbidity and mortality.Objective: To determine endothelial function in severe psoriasis at onset compared to that of matched healthy controls Methods: Using high-resolution ultrasound, we measured the diameter of brachial artery at rest, during reactive hyperemia, and after sublingual nitroglycerin. We compared twenty adult individuals at psoriasis onset to matched healthy controls. Demographic characteristics, lipid profile and high-sensitive C-reactive protein were assessed.Results: There were no significant differences in endothelium-dependent and -independent dilatation between psoriasis patients and control individuals. Patients with psoriasis had significantly higher concentration of high-sensitive Creactive-protein, reflecting the systemic inflammatory response.Conclusion: This is the first pilot study evaluating endothelial function in individuals with early plaque psoriasis. The study shows that patients with severe psoriasis at onset do not exhibit endothelial dysfunction compared to control individuals.

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Section: Discussionmentioning

confidence: 99%

“…Both RA and SLE are associated with endothelial dysfunction [16][17][18][19][20][21]. Flow-mediated vasodilatation (FMD) of the brachial artery by using a high resolution ultrasound is a non-invasive and extensively validated method for assessing systemic endothelial function.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Function and Inflammatory Activity in Patients with Recent Onset of Severe Plaque Psoriasis

Mallbris

Pernowb²,

Ståhle³

2008

TODJ

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“…Kiss et al (16 ) showed that FMD percentages were significantly lower in patients with systemic lupus erythematosus than in the control group. Low percentage of FMD was also found in patients with rheumatoid arthritis because 62 of chronic inflammation (17-18).…”

Section: Discussionmentioning

confidence: 98%

Relationship between endothelial dysfunction and microalbuminuria in familial Mediterranean fever

et al. 2016

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Objective: The aim of our study is to investigate the relationship between microalbuminuria and flow-mediated dilatation in familial Mediterranean fever (FMF) patients.Material and Methods: In our study, there were two groups consisting of 54 patients who were out of the attack period (43 of whom had no microalbuminuria and 11 of whom had microalbuminuria) and 40 healthy controls (M/F: 12/28).Results: There was no statistically difference between patient and control groups'age (25.06±8.07, 22.89±6.00 years, respectively).Flow-mediated dilatation (FMD) percentages were significantly different between the three groups (p=0.01). It was observed that there was a correlation between microalbuminuria and FMD percentage. Conclusion:Endothelial dysfunction and renal damage occurred as a result of low-grade chronic inflammation. Microalbuminuria, which is the indicator of renal damage and endothelial dysfunction, and FMD show that endothelial functions can be used in the following of early detection of renal damage and endothelial functions in FMF patients.

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“…Techniques designed to assess endothelial function are based on measurement of brachial artery reactivity in response to changes in blood-flow caused by passive congestion (flow-mediated vasodilatation, which is dependent on endothelial function) (Corretti et al, 2002). Studies performed in SLE patients documented an impaired endothelial function and this fact was attributed to reduced nitric oxide bioavailability resulting from increased oxidative stress in the course of SLE (El-Magadmi et al, 2004;Kiss et al, 2006;Wright et al, 2006). Furthermore, impairment of endothelial function remained significant even after adjustment for other classic atherosclerosis risk factors and the authors suggested that SLE is an independent risk factor for endothelial dysfunction (El-Magadmi et al, 2004).…”

Section: Atherosclerosis In Systemic Lupus Erythematosus -The Backgroundmentioning

confidence: 99%

Antiphospholipid Antibodies and Their Association with Atherosclerotic Changes in Patients with Systemic Lupus Erythematosus – Review of Literature and Own Experiences

Fischer¹,

Flicinnski²,

Brzosko³

2012

Antiphospholipid Syndrome

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Reduced flow-mediated vasodilation as a marker for cardiovascular complications in lupus patients

Cited by 78 publications

References 35 publications

Endothelial Function and Inflammatory Activity in Patients with Recent Onset of Severe Plaque Psoriasis

Endothelial Function and Inflammatory Activity in Patients with Recent Onset of Severe Plaque Psoriasis

Relationship between endothelial dysfunction and microalbuminuria in familial Mediterranean fever

Antiphospholipid Antibodies and Their Association with Atherosclerotic Changes in Patients with Systemic Lupus Erythematosus – Review of Literature and Own Experiences

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