Reduced forced expiratory flow but not increased exhaled nitric oxide or airway responsiveness to methacholine characterises paediatric sickle cell airway disease

Chaudry, Rifat A; Rosenthal, Mark; Bush, Andrew; Crowley, Suzanne

doi:10.1136/thoraxjnl-2013-204464

Cited by 38 publications

(41 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we found no significant correlations between F eNO indices and R5 or FEV 1 :VC. A larger study (13) reported, as we now do, no difference in F eNO50 ml/s when 50 SCD children were compared to 50 ethnic-matched controls. Furthermore, airflow obstruction, as evidenced by a reduced FEV:VC was not associated with increased methacholine sensitivity or elevated F eNO (13).…”

Section: Discussionmentioning

confidence: 89%

“…A larger study (13) reported, as we now do, no difference in F eNO50 ml/s when 50 SCD children were compared to 50 ethnic-matched controls. Furthermore, airflow obstruction, as evidenced by a reduced FEV:VC was not associated with increased methacholine sensitivity or elevated F eNO (13). Those results (13) led the authors to hypothesize that sickling within the bronchial circulation may lead to airway ischemia and mucosal injury with the subsequent development of fibrosis and progressive airway obstruction.…”

Section: Discussionmentioning

confidence: 89%

“…In one study, F eNO was reduced in SCD patients (11), a possible explanation is reduced nitric oxide (NO) bioavailability resulting from chronic hemolysis and NO scavenging by the cell free hemoglobin (12). A reduced F eNO , however, has not been found in other cohorts (13,14). F eNO has also been shown to be elevated in patients with atrial septal defects or liver cirrhosis.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Airway and alveolar nitric oxide production, lung function, and pulmonary blood flow in sickle cell disease

et al. 2015

View full text Add to dashboard Cite

Background: Children with sickle cell disease (SCD) often have obstructive lung function abnormalities which could be due to asthma or increased pulmonary blood volume; it is important to determine the underlying mechanism to direct appropriate treatment. In asthmatics, exhaled nitric oxide (F eNO ) is elevated. F eNO , however, can also be raised due to increased alveolar production. Our aim, therefore, was to determine if airway or alveolar NO production differed between SCD children and ethnic and age-matched controls. Methods: Lung function, airway NO flux and alveolar NO production, and effective pulmonary blood flow were assessed in 18 SCD children and 18 ethnic and age-matched controls. results: The SCD children compared to the controls had a higher respiratory system resistance (P = 0.0008), alveolar NO production (P = 0.0224), and pulmonary blood flow (P < 0.0001), but not airway NO flux. There was no significant correlation between F eNO and respiratory system resistance in either group, but in the SCD children, there were correlations between alveolar NO production (P = 0.0006) and concentration (P < 0.0001) and pulmonary blood flow. conclusion: Airway NO flux was not elevated in the SCD children nor correlated with airways obstruction, suggesting that airways obstruction, at least in some SCD children, is not due to asthma.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 99%

See 1 more Smart Citation

Airway and alveolar nitric oxide production, lung function, and pulmonary blood flow in sickle cell disease

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Dear Editor, We thank Professor Greenough and Dr Lunt for their interest 1 in our manuscript, 2 and for the suggestion that changes in pulmonary vascular volumes may lead to airflow obstruction. In this group of sickle cell diseased (SCD) children and controls, we used carbon monoxide transfer (DL CO ) related to pulmonary blood flow (Qpeff ) at rest and on exercise as a surrogate for pulmonary capillary blood volume.…”

mentioning

confidence: 99%

Letter to the Editor in reply to ‘Pulmonary vascular volumes and airways obstruction in SCD patients’

Crowley¹,

Chaudry²,

Rosenthal

et al. 2014

Thorax

Self Cite

View full text Add to dashboard Cite

“…Furthermore, Cohen et al [23] showed that there was no difference in the mortality rate of asthmatic and non-asthmatic adults with SCD, but those with SCD and wheeze (independent of asthma diagnosis) were at an increased risk of death when compared to those that did not wheeze. Similarly, lung function appears to be decreased in those with SCD, even in the absence of other indicators of asthma [24, 25]. Abnormal lung function values appear to be correlated with increased pulmonary blood volume in those with SCD [26, 27], but do not appear to correlate with increased future morbidity (e.g., vaso-occlusive crisis or ACS) [28, 29].…”

Section: Introductionmentioning

confidence: 99%

House Dust Mite-Induced Allergic Lung Inflammation Is Not Exacerbated in Sickle Cell Disease Mice

Jiang

Gavitt

Szczepanek

2019

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Aim: Asthma appears to be a common comorbid condition in children with sickle cell disease (SCD), and such individuals may be at a higher risk for increased morbidity and mortality. However, several reports have indicated that asthma severity is not particularly high in those with SCD, and airway hyperreactivity and wheeze may be independently associated with SCD. In SCD mice, exacerbated allergic airway disease (AAD) has been observed in response to the model antigen ovalbumin (OVA). We sought to determine if allergic lung inflammation is also exacerbated in SCD mice when they are exposed to the human allergen, house dust mite (HDM). Methods and Results: Eosinophil counts in bronchoalveolar lavage fluid were determined by cytocentrifugation and increased in both wild-type (WT) and SCD mice after acute exposure to a high dose (25 µg) of HDM, which then decreased in chronically exposed mice. WT mice exposed to a low dose of HDM (1 µg) followed the same pattern of eosinophil flux, but SCD mice did not induce much eosinophilia after acute exposure to HDM. As was observed in previous studies, lung lesions similarly increased in severity in both WT and SCD mice after acute exposure to HDM, which remained elevated after chronic exposure. Furthermore, serum HDM-specific IgE titers similarly increased and selected serum cytokines were similar in both WT and SCD mice. Conclusion: These results contrast with previous reports of exacerbated AAD in SCD mice exposed to OVA and support the alternative hypothesis that asthmatic responses are normal in those with SCD.

show abstract

Reduced forced expiratory flow but not increased exhaled nitric oxide or airway responsiveness to methacholine characterises paediatric sickle cell airway disease

Cited by 38 publications

References 34 publications

Airway and alveolar nitric oxide production, lung function, and pulmonary blood flow in sickle cell disease

Airway and alveolar nitric oxide production, lung function, and pulmonary blood flow in sickle cell disease

Letter to the Editor in reply to ‘Pulmonary vascular volumes and airways obstruction in SCD patients’

House Dust Mite-Induced Allergic Lung Inflammation Is Not Exacerbated in Sickle Cell Disease Mice

Contact Info

Product

Resources

About