Reduced Frontal White Matter Volume in Long-Term Childhood Leukemia Survivors: A Voxel-Based Morphometry Study

Carey, Marissa; Haut, Marc W.; Reminger, Sheryl L.; Hutter, John J.; Theilmann, Rebecca J.; Kaemingk, Kristine L.

doi:10.3174/ajnr.a0904

Cited by 98 publications

(103 citation statements)

References 46 publications

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“…Long-term follow-up that includes neuropsychological assessment has identified specific deficits in survivors of childhood leukemia [73, 74•]. The deficits that are most often reported are poor arithmetic skills [75][76][77] and neuropsychological effects such as decreased attention [76,78,79], problems with memory [80,81], and visualmotor deficits [75,82]. Greater impact on attention and visual-motor performance was associated with higher doses of systemic methotrexate [79,82].…”

Section: Neurotoxicitymentioning

confidence: 99%

Late Effects of Childhood Leukemia Therapy

Fulbright

Raman

McClellan

et al. 2011

Curr Hematol Malig Rep

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As survival rates for children treated for childhood cancers become significantly better, the focus is increasingly on determining the late effects of treatments and the best ways to monitor for them and prevent their occurrence. This review focuses on recent literature discussing the late effects of treatment in patients treated for acute myeloid leukemia and acute lymphoblastic leukemia during childhood. The late effects of therapy for childhood leukemia include secondary malignancy, cardiotoxicity, obesity, endocrine abnormalities, reproductive changes, neurocognitive deficits, and psychosocial effects. As clinicians have become more aware of the late effects of therapy, treatment regimens have been changed to decrease late effects, but patients still require long-term follow-up for their prevention and treatment.

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Section: Neurotoxicitymentioning

confidence: 99%

Late Effects of Childhood Leukemia Therapy

Fulbright

Raman

McClellan

et al. 2011

Curr Hematol Malig Rep

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“…Age at testing, time since treatment, and treatment intensity did not change the relationship between WM volumes and cognitive performance suggesting that reductions in WM volumes may be the direct mechanism for neurocognitive impairment. Carey et al [2008] found reduced WM volumes in the right frontal lobes of ALL survivors (treated with CO) compared to healthy controls. Lower math and vocabulary scores were associated with smaller right frontal WM volumes.…”

Section: Neuroimaging and Neurocognitive Outcomesmentioning

confidence: 99%

“…IQ is generally average [Giralt et al, 1992;Raymond-Speden et al, 2000;Langer et al, 2002;Carey et al, 2008] with no differences between CO and comparison groups [Schlieper et al, 1989;Anderson et al, 1994;Schatz et al, 2000].…”

Section: Long-term Outcomesmentioning

confidence: 99%

Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment

Janzen

Spiegler

2008

Dev Disabil Res Revs

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This review will describe the neurocognitive outcomes associated with pediatric acute lymphoblastic leukemia (ALL) and its treatment. The literature is reviewed with the aim of addressing methodological issues, treatment factors, risks and moderators, special populations, relationship to neuroimaging findings, and directions for future research. It is concluded that neurocognitive outcomes for the majority of children with standard-risk ALL treated according to current chemotherapy protocols is relatively good, but subgroups of children are more significantly compromised. As medical treatments advance and survival rates continue to improve, neurocognitive outcomes and other quality of life indicators will become increasingly important. Preventing or ameliorating treatment-related neuropsychological sequelae represents the next major challenge in pediatric ALL.

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“…The data obtained by Voxel-based morphometry (VBM) studies showed that this is significant in adolescents and children treated for lymphoblastic leukaemia, who mainly have difficulties in tests of attention, visual construction, mental flexibility and mathematics, reading, the production of written language [26] , and in the behavioural sphere [19,[24][25][26] .…”

Section: Late Neurocognitive Effects On Personal Areasmentioning

confidence: 99%

“…Combined radio-and chemotherapy reduced cognitive performances and was associated with memory loss, concentration, and learning problems [5,[13][14][15][16]18] . The most commonly affected neurocognitive functions were loss of attention and concentration [9,10,19,21] , and memory problems [5,13,19] , in particular working memory [10,22] ; also the visuo-motor integration and visuo-spatial abilities [5,9,20,21,[23][24][25] , executive and verbal functions [13,14,20] , speed of execution [13,20] , and problem-solving abilities were affected [20] . On the other hand, chemotherapy alone did not reduce total IQ [16,17] , but was found to affect the neuropsychological abilities that are essential in a number of learning domains and intelligence tests [7,8,20,24,23] .…”

Section: Late Neurocognitive Effects On Personal Areasmentioning

confidence: 99%

Late neurocognitive effects in children and adolescents who have undercone oncological treatment: a rehabilitation model

Masneri

Bolis²

2012

JST

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Oncologists have been driven to face the need to reach their primary goal of patient recovery by reducing or preventing as much as possible late effects in cancer survivors of developmental age as a result of improved oncological treatments, increased survival rates, and their awareness that they are acting in a crucial phase of life. Late effects involve various systems of individual functioning: cardiovascular, respiratory, reproductive and neurocognitive. The aim of this study was to draw attention to late cognitive effects and underline the importance and usefulness of rehabilitation interventions in reducing not only learning difficulties, but also the problems related to socialisation and psychological unease. Neurocognitive outcomes are influenced by the type of cancer treatment, the time that has passed since its administration, surgery, tumour location, and the patient's age and gender. Late effects are generally more severe in cases of radiotherapy, which seems to affect IQ, whereas chemotherapy only seems to affect neuropsychological abilities such as attention, concentration, memory, and executive and visuo-spatial functions. Cognitive outcomes therefore affect not only intellectual and educational functioning, but also social and psychological functioning.It is widely acknowledged that Butler and Copeland's tripartite Cognitive Remediation Program (CRP) can benefit children and adolescents with neurocognitive difficulties due to oncological treatment. It not only improves attention and learning abilities, but also the ability to manage post-treatment cognitive dysfunction more effectively.

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Reduced Frontal White Matter Volume in Long-Term Childhood Leukemia Survivors: A Voxel-Based Morphometry Study

Cited by 98 publications

References 46 publications

Late Effects of Childhood Leukemia Therapy

Late Effects of Childhood Leukemia Therapy

Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment

Late neurocognitive effects in children and adolescents who have undercone oncological treatment: a rehabilitation model

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