Reduced Frontoparietal Activity in Schizophrenia Is Linked to a Specific Deficit in Goal Maintenance: A Multisite Functional Imaging Study

Poppe, Andrew; Deanna, M; Carter, Cameron S.; Gold, James M.; Ragland, J. Daniel; Silverstein, Steven M.; MacDonald, Angus W.

doi:10.1093/schbul/sbw036

Cited by 53 publications

(46 citation statements)

References 51 publications

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“…Previous fMRI whole-brain analyses from our group using a different healthy sample have shown that contrasting B-cues relative to A-cues in the DPX task elicits widespread activations in the cognitive control FPN, including bilateral DLPFC, bilateral fusiform gyri, and right inferior parietal gyrus (Lopez-Garcia et al, 2015). These activation findings have been replicated in the current sample (Poppe et al, 2016) and subsequent functional connectivity analyses have also demonstrated network specific engagement of the FPN during the DPX task (Ray et al, 2017).…”

Section: Data Acquisitionsupporting

confidence: 76%

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Dynamic Reorganization of the Frontal Parietal Network During Cognitive Control and Episodic Memory

Ray

Ragland

Macdonald

et al. 2019

Preprint

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Higher cognitive functioning is supported by adaptive reconfiguration of large-scale functional brain networks. Cognitive control (CC), which plays a vital role in flexibly guiding cognition and behavior in accordance with our goals, supports a range of executive functions via distributed brain networks. These networks process information dynamically and can be represented as functional connectivity changes between network elements.Using graph theory, we explored context-dependent network reorganization in 56 healthy adults performing fMRI tasks from two cognitive domains that varied in CC and episodic-memory demands. We examined whole-brain modular structure during the DPX task, which engages proactive CC in the frontal-parietal cognitive control network (FPN), and the RiSE task, which manipulates CC demands at encoding and retrieval during episodic-memory processing, and engages FPN, the medial-temporal lobe and other memory related networks in a context dependent manner.Analyses revealed different levels of network integration and segregation. High CC conditions exhibited greater integration across tasks. Moreover, nodes associated with higher cognitive functioning displayed the greatest amount of dynamic module reorganization across tasks.Specifically, the FPN displayed a high level of segregation in the DPX task, where only demands for proactive control varied, and more complex network integration with default mode and salience networks in the RiSE task, where CC is differentially integrated during memory encoding and retrieval. These findings provide insight into how brain networks reorganize to support differing task contexts, suggesting that the FPN flexibly segregates during focused proactive control and integrates to support control in other domains such as episodic-memory.

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Section: Data Acquisitionsupporting

confidence: 76%

“…Correct responses from 4 runs of the DPX task that used for analysis. See (Poppe et al, 2016) for more detail regarding the AX-DPX. Figure 2: Illustration of the Dot Pattern Expectancy Task.…”

Section: Data Acquisitionmentioning

confidence: 99%

Dynamic Reorganization of the Frontal Parietal Network During Cognitive Control and Episodic Memory

Ray

Ragland

Macdonald

et al. 2019

Preprint

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“…Behavioral results from our intermodal paradigm (visual cues with auditory targets) were consistent with previous AX-CPT studies that utilized visual stimuli only (Barch et al, 2001;Barch, Carter, MacDonald III, Braver, & Cohen, 2003;Braver et al, 2009;Paxton et al, 2006;Paxton et al, 2008), suggesting that proactive and reactive cognitive control function in a supramodal fashion. RTs were slower for B relative to A cues and for AY relative to AX and BX probes, consistent with designs with longer (Braver et al, 2009;Paxton et al, 2008) rather than shorter (Barch et al, 2001;Poppe et al, 2016) cue-probe delays. BX probes were associated with both decreased accuracy and increased RT variability, which subsequently captured the majority of BSI variance relative to AY trials.…”

Section: Both Probes Followingsupporting

confidence: 71%

Proactive and reactive cognitive control rely on flexible use of the ventrolateral prefrontal cortex

Ryman

Shaikh

Shaff

et al. 2018

Human Brain Mapping

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The role of ventral versus dorsolateral prefrontal regions in instantiating proactive and reactive cognitive control remains actively debated, with few studies parsing cue versus probe‐related activity. Rapid sampling (460 ms), long cue–probe delays, and advanced analytic techniques (deconvolution) were therefore used to quantify the magnitude and variability of neural responses during the AX Continuous Performance Test (AX‐CPT; N = 46) in humans. Behavioral results indicated slower reaction times during reactive cognitive control (AY trials) in conjunction with decreased accuracy and increased variability for proactive cognitive control (BX trials). The anterior insula/ventrolateral prefrontal cortex (aI/VLPFC) was commonly activated across comparisons of both proactive and reactive cognitive control. In contrast, activity within the dorsomedial and dorsolateral prefrontal cortex was limited to reactive cognitive control. The instantiation of proactive cognitive control during the probe period was also associated with sparse neural activation relative to baseline, potentially as a result of the high degree of neural and behavioral variability observed across individuals. Specifically, the variability of the hemodynamic response function (HRF) within motor circuitry increased after the presentation of B relative to A cues (i.e., late in HRF) and persisted throughout the B probe period. Finally, increased activation of right aI/VLPFC during the cue period was associated with decreased motor circuit activity during BX probes, suggesting a possible role for the aI/VLPFC in proactive suppression of neural responses. Considered collectively, current results highlight the flexible role of the VLPFC in implementing cognitive control during the AX‐CPT task but suggest large individual differences in proactive cognitive control strategies.

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“…To the best of our knowledge, this observation has not been reported in previous studies. Concerning the involvement of frontal lobe, it is known that abnormal activity of some specific structures, like for example the middle, the superior and the supramarginal frontal gyrus, is associated to peculiar symptoms of schizophrenia, in particular processing and negative symptoms [28][29][30]. It can be hypothesized that LEV interferes with specific frontal circuits, possibly already damaged by the tumor, contributing to reduce further the activity of frontal lobe and to trigger acute TE-PAEs.…”

Section: Discussionmentioning

confidence: 99%

Brain tumor location influences the onset of acute psychiatric adverse events of levetiracetam therapy: an observational study

Belcastro

Pisani²,

Bellocchi

et al. 2017

J Neurol

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To explore possible correlations among brain lesion location, development of psychiatric symptoms and the use of antiepileptic drugs (AEDs) in a population of patients with brain tumor and epilepsy. The medical records of 283 patients with various types of brain tumor (161 M/122 F, mean age 64.9 years) were analysed retrospectively. Patients with grade III and IV glioma, previous history of epileptic seizures and/or psychiatric disorders were excluded. Psychiatric symptoms occurring after initiation of AED therapy were considered as treatment emergent psychiatric adverse events (TE-PAEs) if they fulfilled the following conditions: (1) onset within 4 weeks after the beginning of AED therapy; (2) disappearance on drug discontinuation; (3) absence of any other identified possible concurrent cause. The possible influence of the following variables were analysed: (a) AED drug and dose; (b) location and neuroradiologic features of the tumor, (c) location and type of EEG epileptic abnormalities, (d) tumor excision already or not yet performed; (e) initiation or not of radiotherapy. TE-PAEs occurred in 27 of the 175 AED-treated patients (15.4%). Multivariate analysis showed a significant association of TE-PAEs occurrence with location of the tumor in the frontal lobe (Odds ratio: 5.56; 95% confidence interval 1.95-15.82; p value: 0.005) and treatment with levetiracetam (Odds ratio: 3.61; 95% confidence interval 1.48-8.2; p value: 0.001). Drug-unrelated acute psychiatric symptoms were observed in 4 of the 108 AED-untreated patients (3.7%) and in 7 of the 175 AED-treated patients (4%). The results of the present study suggest that an AED alternative to levetiracetam should be chosen to treat epileptic seizures in patients with a brain tumor located in the frontal lobe to minimize the possible onset of TE-PAEs.

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Reduced Frontoparietal Activity in Schizophrenia Is Linked to a Specific Deficit in Goal Maintenance: A Multisite Functional Imaging Study

Cited by 53 publications

References 51 publications

Dynamic Reorganization of the Frontal Parietal Network During Cognitive Control and Episodic Memory

Dynamic Reorganization of the Frontal Parietal Network During Cognitive Control and Episodic Memory

Proactive and reactive cognitive control rely on flexible use of the ventrolateral prefrontal cortex

Brain tumor location influences the onset of acute psychiatric adverse events of levetiracetam therapy: an observational study

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