Reduced Global-Brain Functional Connectivity of the Cerebello-Thalamo-Cortical Network in Patients With Dry Eye Disease

Pan, Pan; Wei, Shubao; Ou, Yangpan; Liu, Feng; Li, Huabing; Jiang, Wenyan; Li, Wen-Mei; Lei, Yiwu; Guo, Wenbin; Luo, Shuguang

doi:10.3389/fnhum.2020.572693

Cited by 8 publications

(4 citation statements)

References 58 publications

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“…DE is generally considered to be a corneal disease, but our previous work has shown that some ophthalmologic diseases are accompanied by changes in specific brain areas 5 , 6 , although the nature and significance of this association are unclear. Pan et al used Global-brain FC to analyze the images of 20 dry eye patients and found that the difference in the value of left thalamus can distinguish patients from normal people 7 . The study by Levitt et al also showed that the cause of dry eye pain may be related to abnormal central pain management 8 .…”

Section: Introductionmentioning

confidence: 99%

Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study

Kang

Guo

et al. 2021

Sci Rep

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This study investigated neurologic changes in patients with dry eye (DE) by functional magnetic resonance imaging (fMRI) and to used regional homogeneity (ReHo) analysis to clarify the relationship between these changes and clinical features of DE. A total of 28 patients with DE and 28 matched healthy control (HC) subjects (10 males and 18 females in each group) were enrolled. fMRI scans were performed in both groups. We carried out ReHo analysis to assess differences in neural activity between the 2 groups, and receiver operating characteristic curve (ROC) analysis was performed to evaluate the performance of ReHo values of specific brain areas in distinguishing DE patients from HCs. The relationship between average ReHo values and clinical characteristics was assessed by correlation analysis. ReHo values of the middle frontal gyrus, inferior frontal gyrus, and superior frontal gyrus were significantly lower in DE patients compared to HCs. The ROC analysis showed that ReHo value had high accuracy in distinguishing between DE patients and HCs (P < 0.0001). The ReHo values of the middle frontal gyrus and dorsolateral superior frontal gyrus were correlated to disease duration (P < 0.05). Symptoms of ocular surface injury in DE patients are associated with dysfunction in specific brain regions, which may underlie the cognitive impairment, psychiatric symptoms, and depressive mood observed in DE patients. The decreased ReHo values of some brain gyri in this study may provide a reference for clinical diagnosis and determination of treatment efficacy.

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Section: Introductionmentioning

confidence: 99%

Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study

Kang

Guo

et al. 2021

Sci Rep

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“…In this study, MD values of the right posterior thalamus were significantly different between DE and HC. Pan et al [ 44 ] used the global brain functional connectivity (GFC) method at voxel level to study the differences in functional tissue between DE patients and healthy controls. The GFC changes in the cerebellum-thalamic-cortex network in DE patients may be related to visual impairment and persistent pain symptoms, and reduced GFC may lead to a continuous stress response and reduced pain threshold.…”

Section: Discussionmentioning

confidence: 99%

Altered regional brain white matter in dry eye patients: a brain imaging study

Luo

Liang

et al. 2022

Aging

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This study aimed to investigate the regional changes of brain white matter (WM) in DE patients using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI). A total of 25 dry eye patients (PAT) and 25 healthy controls (HC) were recruited. All subjects underwent DTI and NODDI, fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), isotropic volume fraction (FISO), intra-cellular volume fraction (FICVF), and orientation dispersion index (ODI) were obtained respectively. Then complete Hospital Anxiety and Depression Scale (HADS), anxiety score (AS) or depression scores (DS) were obtained. Receiver operating characteristic (ROC) curve analysis was used to evaluate the reliability of DTI and NODDI in distinguishing the two groups. DTI revealed that PAT had lower FA in both the left superior longitudinal fasciculus (LSLF) and the corpus callosum (CC), and higher MD in the LSLF, the right posterior limb of the internal capsule and the right posterior thalamic radiation. PAT had significant AD changes in regions including the genu of the CC, the right posterior limb of internal capsule, and the right splenium of the CC. From NODDI, PAT showed increased ODI in the LSLF and increased FISO in the right splenium of the CC. FICVF showed a significant decrease in the LSLF while increased in the left anterior corona radiata and the CC. Furthermore, the average values of MD and FICVF were significantly correlated with DS and AS. Hence the results of this study suggest that there are regional changes in WM in DE patients which may contribute to further understanding of the pathological mechanism of DE.

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“…Although topography machines do not measure the eyelid, its footprint can be seen in the Medmont E300's raw data, where the eyelashes interfere with the topography measurement, resulting in slit-like gaps on the resultant map. Additionally, the eyelid geometry follows the overlayed smoothed-out anterior eye geometry when the eyelid is entirely folded, as appeared in X-ray scans [45] and MRI images [46,47]. As detailed information on how the upper and lower eyelid surfaces interact with and apply pressure to the ocular surface was required, the eyelid's three-dimensional shape was reverseengineered from its footprint extracted from the Medmont E300 raw data.…”

Section: Eyelid Edge Detection and Modellingmentioning

confidence: 99%

FEA-Based Stress–Strain Barometers as Forecasters for Corneal Refractive Power Change in Orthokeratology

Wu,

Lin,

et al. 2024

Bioengineering

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Purpose: To improve the effectivity of patient-specific finite element analysis (FEA) to predict refractive power change (RPC) in rigid Ortho-K contact lens fitting. Novel eyelid boundary detection is introduced to the FEA model to better model the effects of the lid on lens performance, and stress and strain outcomes are investigated to identify the most effective FEA components to use in modelling. Methods: The current study utilises fully anonymised records of 249 eyes, 132 right eyes, and 117 left eyes from subjects aged 14.1 ± 4.0 years on average (range 9 to 38 years), which were selected for secondary analysis processing. A set of custom-built MATLAB codes was built to automate the process from reading Medmont E300 height and distance files to processing and displaying FEA stress and strain outcomes. Measurements from before and after contact lens wear were handled to obtain the corneal surface change in shape and power. Tangential refractive power maps were constructed from which changes in refractive power pre- and post-Ortho-K wear were determined as the refractive power change (RPC). A total of 249 patient-specific FEA with innovative eyelid boundary detection and 3D construction analyses were automatically built and run for every anterior eye and lens combination while the lens was located in its clinically detected position. Maps of four stress components: contact pressure, Mises stress, pressure, and maximum principal stress were created in addition to maximum principal logarithmic strain maps. Stress and strain components were compared to the clinical RPC maps using the two-dimensional (2D) normalised cross-correlation and structural similarity (SSIM) index measure. Results: On the one hand, the maximum principal logarithmic strain recorded the highest moderate 2D cross-correlation area of 8.6 ± 10.3%, and contact pressure recorded the lowest area of 6.6 ± 9%. Mises stress recorded the second highest moderate 2D cross-correlation area with 8.3 ± 10.4%. On the other hand, when the SSIM index was used to compare the areas that were most similar to the clinical RPC, maximum principal stress was the most similar, with an average strong similarity percentage area of 26.5 ± 3.3%, and contact pressure was the least strong similarity area of 10.3 ± 7.3%. Regarding the moderate similarity areas, all components were recorded at around 34.4% similarity area except the contact pressure, which was down to 32.7 ± 5.8%. Conclusions: FEA is an increasingly effective tool in being able to predict the refractive outcome of Ortho-K treatment. Its accuracy depends on identifying which clinical and modelling metrics contribute to the most accurate prediction of RPC with minimal ocular complications. In terms of clinical metrics, age, Intra-ocular pressure (IOP), central corneal thickness (CCT), surface topography, lens decentration and the 3D eyelid effect are all important for effective modelling. In terms of FEA components, maximum principal stress was found to be the best FEA barometer that can be used to predict the performance of Ortho-K lenses. In contrast, contact pressure provided the worst stress performance. In terms of strain, the maximum principal logarithmic strain was an effective strain barometer.

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Reduced Global-Brain Functional Connectivity of the Cerebello-Thalamo-Cortical Network in Patients With Dry Eye Disease

Cited by 8 publications

References 58 publications

Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study

Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study

Altered regional brain white matter in dry eye patients: a brain imaging study

FEA-Based Stress–Strain Barometers as Forecasters for Corneal Refractive Power Change in Orthokeratology

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