Reduced graphene oxide aerogel networks with soft interfacial template for applications in bone tissue regeneration

Asha, S.; Ananth, A. Nimrodh; Rajan, M. A. Jothi

doi:10.1007/s13204-018-0803-z

Cited by 19 publications

(22 citation statements)

References 48 publications

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“…Photographs showing the antibacterial activity of the prepared CS–GEL/nZnO containing different amounts of zinc oxide nanoparticles against E. coli and S. aureus using serial dilution method. The slices indicated using a red three angel show the seventh dilution step which the difference between samples was observable (a) and quantification of the antibacterial activity in this dilution step (b) (* p < 0.05, t test). [Color figure can be viewed at wileyonlinelibrary.com]…”

Section: Resultsmentioning

confidence: 99%

“…The aim of tissue engineering is repair or regeneration of injured tissue using engineered scaffold instead of transplanting whole organs . Scaffolds act like a temporary matrix for growth and proliferation of the cells to regenerate the damaged tissue . Scaffolds with the ability to deliver bioactive materials and drugs help restore functions of the damaged tissue during regeneration process .…”

Section: Introductionmentioning

confidence: 99%

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In situsynthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

Rakhshaei

Namazi

Hamishehkar

et al. 2019

J of Applied Polymer Sci

107

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In this work, chitosan–gelatin/zinc oxide nanocomposite hydrogel scaffolds (CS–GEL/nZnO) were prepared via in situ synthesis of ZnO nanoparticles (nZnO) to reach a scaffold with both inherent antibacterial and drug delivery properties. The prepared nanocomposite hydrogel scaffolds were characterized using scanning electron microscopy, transmission electron microscopy, atomic absorption spectrometer, Fourier transform infrared spectroscopy, and X‐ray diffraction. In addition, swelling, biodegradation, antibacterial, cytocompatibility, and cell attachment of the scaffolds were evaluated. The results showed that the prepared scaffolds had high porosity with a pore size of 50–400 μm and nZnO were well distributed without any agglomeration on the CS–GEL matrix. In addition, the nanocomposite scaffolds showed enhanced swelling, biodegradation, and antibacterial properties. Moreover, the drug delivery studies using naproxen showed that nZnO could control naproxen release. Cytocompatibility of the samples was proved using normal human dermal fibroblast cells (HFF2). In comparison to the previous reports which nZnO were simply added to the matrix of the scaffold, in situ synthesis of nZnO was led to higher antibacterial and lower cytotoxicity effects as a result of well distribution of nZnO in this method. According to the findings, the in situ synthesized CS–GEL/nZnO is strongly recommended for biomedical applications especially skin tissue engineering. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47590.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In situsynthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

Rakhshaei

Namazi

Hamishehkar

et al. 2019

J of Applied Polymer Sci

107

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“…Another study showed that chitosan acted as an interfacial soft polymeric template on the surface of RGO, promoting an ordered growth of the hydroxyapatite particles. The three-component composite mineralized scaffold mimicked the structure and composition of natural bone and exhibited a relatively higher rate of cell proliferation, osteogenic differentiation, and osteoid matrix formation [ 113 ].…”

Section: Applications Of Chitosan-based Biomimetically Mineralizedmentioning

confidence: 99%

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Ren

et al. 2020

Molecules

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Chitosan is a natural, biodegradable cationic polysaccharide, which has a similar chemical structure and similar biological behaviors to the components of the extracellular matrix in the biomineralization process of teeth or bone. Its excellent biocompatibility, biodegradability, and polyelectrolyte action make it a suitable organic template, which, combined with biomimetic mineralization technology, can be used to develop organic-inorganic composite materials for hard tissue repair. In recent years, various chitosan-based biomimetic organic-inorganic composite materials have been applied in the field of bone tissue engineering and enamel or dentin biomimetic repair in different forms (hydrogels, fibers, porous scaffolds, microspheres, etc.), and the inorganic components of the composites are usually biogenic minerals, such as hydroxyapatite, other calcium phosphate phases, or silica. These composites have good mechanical properties, biocompatibility, bioactivity, osteogenic potential, and other biological properties and are thus considered as promising novel materials for repairing the defects of hard tissue. This review is mainly focused on the properties and preparations of biomimetically mineralized composite materials using chitosan as an organic template, and the current application of various chitosan-based biomimetically mineralized composite materials in bone tissue engineering and dental hard tissue repair is summarized.

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“…The lower thermal conductivity of heat due to the high porosity and randomly oriented structure and large specific surface are is able to function for particular substance adsorption, like oils [23]. Graphene in the form of aerogels is used as 2D drug delivery system and also in tissue engineering manipulations [24,25].…”

Section: Graphenementioning

confidence: 99%

Current Use of Carbon-Based Materials for Biomedical Applications—A Prospective and Review

Rajakumar

Zhang

Gomathi³

et al. 2020

Processes

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Among a large number of current biomedical applications in the use of medical devices, carbon-based nanomaterials such as graphene (G), graphene oxides (GO), reduced graphene oxide (rGO), and carbon nanotube (CNT) are frontline materials that are suitable for developing medical devices. Carbon Based Nanomaterials (CBNs) are becoming promising materials due to the existence of both inorganic semiconducting properties and organic π-π stacking characteristics. Hence, it could effectively simultaneously interact with biomolecules and response to the light. By taking advantage of such aspects in a single entity, CBNs could be used for developing biomedical applications in the future. The recent studies in developing carbon-based nanomaterials and its applications in targeting drug delivery, cancer therapy, and biosensors. The development of conjugated and modified carbon-based nanomaterials contributes to positive outcomes in various therapies and achieved emerging challenges in preclinical biomedical applications. Subsequently, diverse biomedical applications of carbon nanotube were also deliberately discussed in the light of various therapeutic advantages.

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Reduced graphene oxide aerogel networks with soft interfacial template for applications in bone tissue regeneration

Cited by 19 publications

References 48 publications

In situsynthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

In situsynthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Current Use of Carbon-Based Materials for Biomedical Applications—A Prospective and Review

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