Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severity

Al-Zadjali, Jamila; Al-Lawati, Amal; Al Riyami, Nafila; Al Farsi, Koukab; Al Jarradi, Najwa; Boudaka, Ammar; Al Barhoumi, Ali; Al Lawati, Mohsen; Al Khaifi, Amani; Musleh, Asma; Gebrayel, Prisca; Vaulont, Sophie; Peyssonnaux, Carole; Edeas, Marvin; Saleh, Jumana

doi:10.1016/j.clinsp.2024.100344

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Moreover, HDL-c, LDL-c, total cholesterol, and triglyceride were significantly lower in the patients with COVID-19 during the first wave of COVID-19, demonstrating that lipid profile predicts the severity of SARS-CoV-2 infection 52 . Al-Zadjali et al demonstrated that low HDL-c levels are associated with increase long-term COVID-19 severity in unvaccinated patients infected with SARS-CoV-2 after the first wave of COVID-19 53 . Regarding vaccination, a study focused on analyzing the lipid profile before and after the two doses of the COVID-19 vaccination in patients without exposure to SARS-CoV-2 infection revealed that triglyceride levels were significantly decreased and cholesterol, HDL-c, and LDL-c levels were significantly increased in patients who received the mRNA-1273 (Moderna) vaccine 54 .…”

Section: Discussionmentioning

confidence: 99%

Association between lipid profile and clinical outcomes in COVID-19 patients

Ochoa-Ramírez,

De la Herrán Arita,

Sanchez-Zazueta

et al. 2024

Sci Rep

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High-density lipoprotein cholesterol (HDL-c) removes cholesterol, an essential component in lipid rafts, and this cholesterol removal can regulate protein attachment to lipid rafts, modulating their functionality in the immune cell response. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can alter the lipid profile, there is little information on the role of HDL-c and other lipids in prognostic of the coronavirus disease 2019 (COVID-19) in Mexican population. This study aims to evaluate the predictive value of HDL-c and lipid profile on severity and survival of 102 patients infected with SARS-CoV-2 during the COVID-19 first wave. Our findings, derived from univariate and multivariate Cox proportional hazards regression models, highlighted age and hypertension as significant predictors of survival (HR = 1.04, p = 0.012; HR = 2.78, p = 0.027), while gender, diabetes, and obesity showed no significant impact. Triglycerides and HDL-c levels notably influenced mortality, with elevated triglycerides and lower HDL-c associated with higher mortality risk (p = 0.032). This study underscores the importance of lipid profiles alongside traditional risk factors in assessing COVID-19 risk and outcomes. It contributes to the understanding of COVID-19 patient management and emphasizes the need for further investigation into the role of dyslipidemia in influencing COVID-19 prognosis, potentially aiding in refined risk stratification and therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Association between lipid profile and clinical outcomes in COVID-19 patients

Ochoa-Ramírez,

De la Herrán Arita,

Sanchez-Zazueta

et al. 2024

Sci Rep

View full text Add to dashboard Cite

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Addressing Post-Acute COVID-19 Syndrome in Cancer Patients, from Visceral Obesity and Myosteatosis to Systemic Inflammation: Implications in Cardio-Onco-Metabolism

Quagliariello,

Canale,

Bisceglia

et al. 2024

Biomedicines

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Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in the world. The emerging field of cardio-oncology described several shared risk factors that predispose patients to both cardiovascular disease and cancer. Post-acute COVID-19 syndrome is a chronic condition that occurs in many patients who have experienced a SARS-CoV-2 infection, mainly based on chronic fatigue, sedentary lifestyle, cramps, breathing difficulties, and reduced lung performance. Post-acute COVID-19 exposes patients to increased visceral adiposity, insulin resistance, myosteatosis, and white adipose tissue content (surrounded by M1 macrophages and characterized by a Th1/Th17 phenotype), which increases the risk of cardiovascular mortality and cancer recurrence. In this review, the main metabolic affections of post-acute COVID-19 syndrome in cancer patients at low and high risk of cardiomyopathies will be summarized. Furthermore, several non-pharmacological strategies aimed at reducing atherosclerotic and cardiac risk will be provided, especially through anti-inflammatory nutrition with a low insulin and glycemic index, appropriate physical activity, and immune-modulating bioactivities able to reduce visceral obesity and myosteatosis, improving insulin-related signaling and myocardial metabolism.

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Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severity

Cited by 2 publications

References 38 publications

Association between lipid profile and clinical outcomes in COVID-19 patients

Association between lipid profile and clinical outcomes in COVID-19 patients

Addressing Post-Acute COVID-19 Syndrome in Cancer Patients, from Visceral Obesity and Myosteatosis to Systemic Inflammation: Implications in Cardio-Onco-Metabolism

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