Reduced heart rate variability in remitted bipolar disorder and recurrent depression

Bassett, Darryl; Bear, Natasha; Nutt, David; Hood, Sean; Bassett, Sherylee; Hans, Davinder

doi:10.1177/0004867416652734

Cited by 34 publications

(21 citation statements)

References 51 publications

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“…Some did not voluntarily adopt this position, but were pushed into it by their progressing illness. In line with previous research pointing to reduced biological flexibility in terms of heart rate variability [44] and gait patterns [45], we found that some participants presented a “social inflexibility” at work, for example the urge to avoid social interaction and the difficulty to let go of responsibilities . In several ways, the inter-subjectivity at work appeared to be very important in the work instability process.…”

Section: Discussionsupporting

confidence: 91%

Working in dissonance: experiences of work instability in workers with common mental disorders

et al. 2017

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BackgroundCommon mental disorders have a negative impact on work functioning, but less is known about the process when the functioning starts to destabilize. This study explores experiences of work instability in workers with common mental disorders.MethodsA grounded theory study using a theoretical sampling frame, individual in-depth interviews and a constant comparative analysis conducted by a multidisciplinary research team. The sample involved 27 workers with common mental disorders, currently working full or part time, or being on sick leave not more than 6 months. They were women and men of different ages, representing different occupations and illness severity.ResultsA general process of work instability was conceptualized by the core category Working in dissonance: captured in a bubble inside the work stream. The workers described that their ordinary fluency at work was disturbed. They distanced themselves from other people at and outside work, which helped them to regain their flow but simultaneously made them feel isolated. Four categories described sub-processes of the dissonance: Working out of rhythm, Working in discomfort, Working disconnected and Working in a no man’s land.ConclusionsThe experience of work instability in CMDs was conceptualized as “working in dissonance”, suggesting a multifaceted dissonance at work, characterized by a sense of being caught up, as if in a bubble. Focusing on how the worker can re-enter their flow at work when experiencing dissonance is a new approach to explore in occupational and clinical settings.Electronic supplementary materialThe online version of this article (doi:10.1186/s12889-017-4388-3) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Working in dissonance: experiences of work instability in workers with common mental disorders

et al. 2017

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“…Heart rate variability (HRV), among others, describes fluctuations between intervals of consecutive heartbeats as a result of ANS dynamics on cardiovascular control that maintain the dynamic equilibrium of vital functions (Xhyheri et al, 2012). Reductions in HRV have not only been found in MDD but in various psychiatric disorders such as schizophrenia (Moon et al, 2013), bipolar disorder (Bassett, 2015;Bassett et al, 2016;Henry et al, 2010) or post-traumatic stress disorder (Moon et al, 2013). Kemp and colleagues (2010) conducted a meta-analysis examining HRV in 18 samples of altogether 673 patients suffering from MDD and 407 healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Intensified emotion perception in depression: Differences in physiological arousal and subjective perceptions

Wenzler

Hagen

Tarvainen

et al. 2017

Psychiatry Research

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People suffering from depression perceive themselves and their surroundings as more negative than healthy ones. An explanation might be that depressed individuals experience negative information as more stressful than non-depressed subjects and, consequently, respond in an amplified manner on a subjective and physiological level. To test this proposition, we presented 41 patients with recurrent depressive episodes and 42 controls with stimuli from the International Affective Picture System split into three valence categories while different parameters of physiological arousal (e.g., heart rate variability) and subjective perceptions of valence and arousal were assessed. Furthermore, we examined social skills and emotional competence. Results regarding physiological arousal revealed an elevated skin temperature and a more accentuated respiratory frequency in depressed subjects. Furthermore, depressed subjects rated the stimuli as more negative and arousing, which was associated with reduced social and emotional competence. Variation in antidepressant medication, menstrual cycle and other factors that have an impact on HRV are a potential bias. Our findings suggest an intensified perception of negative emotion in depressed individuals as compared to controls that manifests itself in an increased physiological arousal as well as on a subjective level. This intensified emotion perception is further associated with deficits in social and emotional competence.

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“…Lower HRV is a predictor of cardiac morbidity and mortality (100–102). Psychiatric patients tend to have an autonomic imbalance with low HRV suggesting a reduced parasympathetic and increased sympathetic tone (103–105). Low HRV has also been related to psychotic symptoms and depression (106–108); and thus, the vagal tone could serve as an index of the treatment response (109).…”

Section: Does Autonomic Immunomodulation Contribute To the Inflammatomentioning

confidence: 99%

Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Activation of the Alpha-7 Nicotinic Acetylcholine Receptor

et al. 2017

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Schizophrenia is one of the most debilitating mental disorders and is aggravated by the lack of efficacious treatment. Although its etiology is unclear, epidemiological studies indicate that infection and inflammation during development induces behavioral, morphological, neurochemical, and cognitive impairments, increasing the risk of developing schizophrenia. The inflammatory hypothesis of schizophrenia is also supported by clinical studies demonstrating systemic inflammation and microglia activation in schizophrenic patients. Although elucidating the mechanism that induces this inflammatory profile remains a challenge, mounting evidence suggests that neuroimmune interactions may provide therapeutic advantages to control inflammation and hence schizophrenia. Recent studies have indicated that vagus nerve stimulation controls both peripheral and central inflammation via alpha-7 nicotinic acetylcholine receptor (α7nAChR). Other findings have indicated that vagal stimulation and α7nAChR-agonists can provide therapeutic advantages for neuropsychiatric disorders, such as depression and epilepsy. This review analyzes the latest results regarding: (I) the immune-to-brain pathogenesis of schizophrenia; (II) the regulation of inflammation by the autonomic nervous system in psychiatric disorders; and (III) the role of the vagus nerve and α7nAChR in schizophrenia.

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Reduced heart rate variability in remitted bipolar disorder and recurrent depression

Abstract: Autonomic function during bedtime was impaired in subjects with Bipolar I and recurrent Major Depressive Disorder, despite clinical remission. This has significant implications for the morbidity and mortality of patients with major mood disorders.

Cited by 34 publications

References 51 publications

Working in dissonance: experiences of work instability in workers with common mental disorders

Working in dissonance: experiences of work instability in workers with common mental disorders

Intensified emotion perception in depression: Differences in physiological arousal and subjective perceptions

Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Activation of the Alpha-7 Nicotinic Acetylcholine Receptor

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