Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water

Huang, Kuo‐Chin; Yang, Chi‐Rei; Lee, Kun Tai; Chien, Chiang Ting

doi:10.1046/j.1523-1755.2003.00118.x

Cited by 130 publications

(128 citation statements)

References 35 publications

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“…Jin et al (9) and Kim et al (10) demonstrated anti-diabetic effect of ERW through the results of reduced blood glucose concentration, increased blood insulin level, improved glucose tolerance and preserved pancreatic β-cell mass using diabetic animal model. Huang et al (7,8) demonstrated the potential therapeutic effects of ERW through reduction of hemodialysis-induced oxidative stress and erythrocyte impairment in end-stage renal disease patients. ERW also has a tendency to suppress single-strand breakage of DNA induced by ROS in vitro (19) and selectively stimulates the growth of anaerobic microflora in the human intestinal tract (23).…”

Section: Referencesmentioning

confidence: 99%

Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats

Park

Song

et al. 2009

Biomed. Res.

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Ethanol consumption disturbs the balance between the pro-and anti-oxidant systems of the organism, leading to oxidative stress. Electrolyzed-reduced water (ERW) is widely used by people in East Asia for drinking purposes because of its therapeutic properties including scavenging effect of reactive oxygen species. This study was performed to investigate the effect of ERW on acute ethanol-induced hangovers in Sprague-Dawley rats. Alcohol concentration in serum of ERWtreated rats showed significant difference at 1 h, 3 h and 5 h respectively as compared with the rats treated with distilled water. Both alcohol dehydrogenase type 1 and acetaldehyde dehydrogenase related with oxidation of alcohol were significantly increased in liver tissue while the level of aspartate aminotransferase and alanine aminotransferase in serum was markedly decreased 24 h after pre-oral administration of ERW. Moreover, oral administration of ERW significantly activated non-ezymatic (glutathione) and enzymatic (glutathione peroxidase, glutathione-S-transferase, Cu/Zn-superoxide dismutase and catalase) antioxidants in liver tissues compared with the control group. These results suggest that drinking ERW has an effect of alcohol detoxification by antioxidant mechanism and has potentiality for relief of ethanol-induced hangover symptoms.

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Section: Referencesmentioning

confidence: 99%

Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats

Park

Song

et al. 2009

Biomed. Res.

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“…However, this procedure can lead to oxidative stress causing cardiovascular disease. A clinical study was performed on 22 men and 15 women submitted to haemodialysis performed with ERAW provided by a commercial apparatus HD-24K (Nihon Trim Co., Osaka, Japan) that was adapted to a AF-150 haemodialyzer equipped with AF-150 membranes (Althane, Althin Medical Inc., Miami, FL, USA) [45]. The following blood parameters were measured: total anti-oxidant state (TAS), anti-oxidant activity of plasma, level of proteins/oxidised amino acids, lipid peroxidation, interleukin-6 (IL6) levels and the concentration of C-reactive protein.…”

Section: Haemodialysismentioning

confidence: 99%

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

Henry

Chambron

2013

Water

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Abstract:The consumption of alkaline reduced water produced by domestic electrolysis devices was approved in Japan in 1965 by the Ministry of Health, Labour and Welfare for the cure of gastro-intestinal disorders. Today, these devices are freely available in several countries and can be easily purchased without reserve. The commercial information included with the device recommends the consumption of 1-1.5 L of water per day, not only for gastro-intestinal disorders but also for numerous other illnesses such as diabetes, cancer, inflammation, etc. Academic research in Japan on this subject has been undergoing since 1990 only but has established that the active ingredient is dissolved dihydrogen that eliminates the free radical HO• in vivo. In addition, it was demonstrated that degradation of the electrodes during functioning of the device releases very reactive nanoparticles of platinum, the toxicity of which has not yet been clearly proven. This report recommends alerting health authorities of the uncontrolled availability of these devices used as health products, but which generate drug substances and should therefore be sold according to regulatory requirements.

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“…Co, Sendai, Japan). 9 The recorded CL signals from the test mixtures containing plasma were referred to as plasma "reference H 2 O 2 counts" (pRH 2 O 2 ) or plasma "reference HOCl counts" (pRHOCl). A higher pRH 2 O 2 or pRHOCl indicated higher ROS activity or lower antioxidative activity (lower ROS scavenging ability), or both, in plasma.…”

Section: Measurement Of Specific Plasma Antioxidant Activitymentioning

confidence: 99%

“…5 The increased oxidative stress can cause oxidation of biological macromolecules, including proteins and lipids. 6,7 The 2 major ROS generated from activated PMNs via the myeloperoxidase (MPO) system are hydrogen peroxide (H 2 O 2 ) and hypochlorite (HOCl), 8 which can produce lipid peroxidation products, malonealdehyde (MDA), and phosphatidylcholine hydroperoxide (PCOOH) 9,10 and protein oxidation products, diotyrosine and methylguanidine, as indirect indicators of ROS and/or free radical activity. 11,12 Among these oxidized products, oxidized LDL (oxLDL) can increase the adhesion of monocytes to the endothelium and transformation of macrophages into foam cells and impair endothe-lium-dependent vasorelaxation.…”

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confidence: 99%

Ascorbate Supplement Reduces Oxidative Stress in Dyslipidemic Patients Undergoing Apheresis

Chien

Chang

Chen

et al. 2004

ATVB

Self Cite

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Objective-The effect of ascorbate treatment on apheresis-induced oxidative stress in uremic and dyslipidemic patients was evaluated. Methods and Results-We developed a chemiluminescence-emission spectrum and high-performance liquid chromatography analysis to assess the effect of ascorbate supplement on plasma reactive oxygen species (ROS) scavenging activity and oxidized lipid/protein production in hyperlipidemic and uremic patients undergoing apheresis. Apheresis was efficient in reduction of atherogenic lipoproteins, complement, fibrinogen, soluble intercellular adhesion molecule-1, and oxidative parameters including phosphatidylcholine hydroperoxide (PCOOH), malonaldehyde, methylguanidine, and diotyrosine. Apheresis itself, however, activated leukocytes to increase ROS activity and reduced the plasma ROS scavenging activity. Ascorbate administration selectively diminished apheresis-enhanced H 2 O 2 and inflammatory mediators such as tumor necrosis factor alpha (TNF-␣) and monocyte chemoattractant protein-1. Chronically dyslipidemic and uremic patients undergoing biweekly apheresis plus ascorbate treatment had lower levels of C-reactive protein and PCOOH than did those without ascorbate treatment during a 6-month follow-up study period. Conclusions-We

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Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water

Abstract: This study demonstrates that hemodialysis with ERW administration may efficiently increase the H2O2- and HOCl-dependent antioxidant defense and reduce H2O2- and HOCl-induced oxidative stress.

Cited by 130 publications

References 35 publications

Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats

Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

Ascorbate Supplement Reduces Oxidative Stress in Dyslipidemic Patients Undergoing Apheresis

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