Reduced IFN-γ and IL-10 responses to paternal antigens during and after pregnancy in allergic women

Persson, Magnus; Ekerfelt, Christina; Ernerudh, Jan; Matthiesen, Leif; Abelius, Martina Sandberg; Jonsson, Yvonne; Berg, Göran; Jenmalm, Maria C.

doi:10.1016/j.jri.2012.05.003

Cited by 6 publications

(10 citation statements)

References 45 publications

(64 reference statements)

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“…The background factors and allergic manifestations in these children until seven years of age are described in Table 1. Non-atopic controls participated in an investigation of immune responses to paternal antigens during pregnancy (23). For Swedish mothers, the median age was 29 years (range 21 to 44 years).…”

Section: Methodsmentioning

confidence: 99%

Human seroreactivity to gut microbiota antigens

Christmann

Abrahamsson

Bernstein

et al. 2015

Journal of Allergy and Clinical Immunology

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Background While immune responses directed against antigens from the intestinal microbiota are observed in certain diseases, the normal human adaptive immune response to intestinal microbiota is poorly defined. Objective Our goal was to assess the adaptive immune response to the intestinal microbiota present in 143 healthy adults and compare this response to the immune response observed in 52 children and their mothers at risk of having allergic disease. Methods Human serum was collected from adults and from children followed from birth to seven years of age, and the serum IgG response to a panel of intestinal microbiota antigens was assessed using a novel protein microarray. Results Nearly every individual tested, regardless of health status, had serum IgG that recognized a common set of antigens. Seroreactivity to the panel of antigens was significantly lower in atopic adults. Healthy infants expressed the highest level of IgG seroreactivity to intestinal microbiota antigens. This adaptive response developed between 6 and 12 months of age, and peaked around 2 years of age. Low IgG responses to certain clusters of microbiota antigens during infancy were associated with allergy development during childhood. Conclusions There is an observed perturbation of the adaptive response to antigens from the microbiota in allergic individuals. These perturbations are observable even in childhood, suggesting that optimal stimulation of the adaptive immune system by the microbiota may be needed to prevent certain immune-mediated diseases.

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Section: Methodsmentioning

confidence: 99%

Human seroreactivity to gut microbiota antigens

Christmann

Abrahamsson

Bernstein

et al. 2015

Journal of Allergy and Clinical Immunology

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“…In contrast, the IFN-γ responses was not altered in the allergic group. We have previously reported a decreased capacity of the allergic women in this cohort to produce IFN-γ and IL-10 to paternal antigens and pooled unrelated antigens during pregnancy (paper SIII, [134]). Thus, certain antigens may modulate Th1-and Th2-responses during pregnancy whereas other antigens do not.…”

mentioning

confidence: 69%

“…The non-allergic women showed decreased allergen-induced IL-13 secretion in late gestation while the IL-13 secretion remained high in the allergic women [151]. Furthermore, allergic women had reduced IFN-γ and IL-10 production in response to fetal and paternal alloantigens during and after pregnancy [134][135][136].…”

Section: Allergy and Pregnancymentioning

confidence: 94%

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Immunological interactions between mother and child during pregnancy in relation to the development of allergic diseases in the offspring

Abelius¹

2014

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“…However, only a few studies have been conducted to study the effect of pregnancy on the immunity of allergic and non‐allergic women . The idea of a pronounced Th2‐immunity during pregnancy in allergic women is supported by the observation of increased total IgE levels in the first and the third trimester, a lack of downregulation of allergen‐induced IL‐13 production in the third trimester as compared to post‐partum, as well as reduced IFN‐γ and IL‐10 secretion in response to foetal and paternal alloantigen during and after pregnancy . The effect of pregnancy at the systemic level has been studied previously in women with the Th1‐associated diseases such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS).…”

Section: Introductionmentioning

confidence: 99%