Reduced IL-7R T Cell Expression and Increased Plasma sCD127 in Late Presenting HIV-Infected Individuals

Hartling, Hans J.; Jespersen, Sofie; Gaardbo, Julie C.; Sambleben, Camilla; Thorsteinsson, Kristina; Gerstoft, Jan; Ullum, Henrik; Nielsen, Susanne Dam

doi:10.1097/qai.0000000000001153

Cited by 14 publications

(8 citation statements)

References 38 publications

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“…demonstrated that neither the plasma level of IL‐7 nor CD127 expression on CD4 + T cells was associated with an increase in the total CD4 + T‐cell count after initiation of ART. In contrast, they found positive associations between baseline CD127 density on CD4 + T cells and an increase in CD4 + RTE cell counts and naïve CD4 + T‐cell counts after 2 years of effective ART, indicating that CD127 expression on CD4 + T cells is a predictor of increased thymic output after 2 years of suppressive ART . Furthermore, a few studies have found that in INRs, plasma levels of IL‐7 were elevated and CD127 expression both on CD4 + and CD8 + T cells was decreased; however, there was no statistically significant correlation between the baseline plasma IL‐7 level and absolute CD4 + T‐cell count after successful ART .…”

Section: Potential Mechanisms Of Incomplete Immune Reconstitutionmentioning

confidence: 93%

“…56,57 It has been reported that in In contrast, they found positive associations between baseline CD127 density on CD4 + T cells and an increase in CD4 + RTE cell counts and naïve CD4 + T-cell counts after 2 years of effective ART, indicating that CD127 expression on CD4 + T cells is a predictor of increased thymic output after 2 years of suppressive ART. 60 Furthermore, a few studies have found that in INRs, plasma levels of IL-7 were elevated and CD127 expression both on CD4 + and CD8 + T cells was decreased; however, there was no statistically significant correlation between the baseline plasma IL-7 level and absolute CD4 + T-cell count after successful ART. 61 Furthermore, others have shown a positive association 59,62 or a negative association [63][64][65] ECs is equivalent to that in healthy subjects.…”

Section: Cytokinesmentioning

confidence: 99%

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Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders

Yang

Zhang

et al. 2020

Journal of Leukocyte Biology

214

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The morbidity and mortality of HIV type‐1 (HIV‐1)‐related diseases were dramatically diminished by the grounds of the introduction of potent antiretroviral therapy, which induces persistent suppression of HIV‐1 replication and gradual recovery of CD4+ T‐cell counts. However, ∼10–40% of HIV‐1‐infected individuals fail to achieve normalization of CD4+ T‐cell counts despite persistent virological suppression. These patients are referred to as “inadequate immunological responders,” “immunodiscordant responders,” or “immunological non‐responders (INRs)” who show severe immunological dysfunction. Indeed, INRs are at an increased risk of clinical progression to AIDS and non‐AIDS events and present higher rates of mortality than HIV‐1‐infected individuals with adequate immune reconstitution. To date, the underlying mechanism of incomplete immune reconstitution in HIV‐1‐infected patients has not been fully elucidated. In light of this limitation, it is of substantial practical significance to deeply understand the mechanism of immune reconstitution and design effective individualized treatment strategies. Therefore, in this review, we aim to highlight the mechanism and risk factors of incomplete immune reconstitution and strategies to intervene.

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Section: Potential Mechanisms Of Incomplete Immune Reconstitutionmentioning

confidence: 93%

Section: Cytokinesmentioning

confidence: 99%

Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders

Yang

Zhang

et al. 2020

Journal of Leukocyte Biology

214

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“…Implementation of D2C varies across jurisdictions, and published reports describe successful re-linkage outcomes from 3 main D2C referral sources: (1) health care providers [ 9–11 ], (2) HIV surveillance [ 12–16 ], and (3) a combination approach in which a list of patients lost to follow-up from an HIV care clinic is matched to HIV surveillance [ 3 , 6 , 17–19 ]. Several jurisdictions cite inefficiencies of surveillance-only-generated referrals because of the overidentification of “current to care” PWH who appear to be NIC by surveillance because of delayed lab reporting or relocation across state lines [ 11 , 13 , 14 , 16 , 20 , 21 ].…”

mentioning

confidence: 99%

“Is a Bird in the Hand Worth 5 in the Bush?”: A Comparison of 3 Data-to-Care Referral Strategies on HIV Care Continuum Outcomes in San Francisco

Sachdev

Mara

Hughes

et al. 2020

Open Forum Infectious Diseases

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BACKGROUND Health departments utilize HIV surveillance data to identify people living with HIV (PWH) who need re-linkage to HIV care as part of an approach known as Data to Care (D2C.) The most accurate, effective and efficient method of identifying PWH for re-linkage is unknown. METHODS We evaluated referral and care continuum outcomes among PWH identified using three D2C referral strategies: health care providers, surveillance, and a combination list derived by matching an electronic medical record registry to HIV surveillance. PWH who were enrolled in the re-linkage intervention received short-term case management for up to 90 days. Relative risks and 95% confidence intervals were calculated to compare proportions of PWH retained and virally suppressed before and after re-linkage. Durable viral suppression was defined as having suppressed viral loads at all viral load measurement in 12 months after re-linkage. RESULTS After initial investigation, 233 (24%) of 954 referrals were located and enrolled in navigation. Although the number of surveillance and provider referrals were similar, 72% of enrolled PWH were identified by providers, 16% by surveillance and 12% by combination list. Overall, retention and viral suppression improved, although relative increases in retention and viral suppression were only significant among individuals identified by surveillance or providers. Seventy percent of PWH who achieved viral suppression after the intervention remained durably virally suppressed. CONCLUSIONS PWH referred by providers were most likely to be located and enrolled in navigation than PWH identified by surveillance or combination lists. Overall, D2C re-linkage efforts improved retention, viral suppression and durable viral suppression.

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“…It is necessary to identify the main CD4+ and CD8+ T-cell subsets which are affected by HCV infection. In addition, studies of functional changes in T-lymphocytes like exhaustion [159][160][161], senescence [162][163][164], and loss of cytokine receptors [165,166] must occur. It is also important to understand the nature of the immune system activation in HIV/ HCV coinfection which is important in predicting the development of non-AIDS-defining diseases.…”

Section: Resultsmentioning

confidence: 99%

Immune Disorders in HIV-Infected Patients Coinfected with Hepatitis C Virus

Shmagel¹,

Сайдакова²

2018

Advances in HIV and AIDS Control

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In Russia, more than half of HIV-infected people are coinfected with hepatitis C. Both viruses interact with the immune system compounding the disease course. HIV infection accelerates the onset of hepatitis-mediated liver fibrosis and cirrhosis. Hepatitis C slows down the recovery of CD4+ T-lymphocytes during antiretroviral treatment and fuels the already intense chronic inflammation. In the present review, we discuss coinfection prevalence and reasons for its abundance, provide extensive coverage of the known mechanisms that give rise to the detrimental health effects in HIV/hepatitis C-coinfected patients, and report our own data on the double infection consequences in people with discordant immunologic response to treatment.

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Reduced IL-7R T Cell Expression and Increased Plasma sCD127 in Late Presenting HIV-Infected Individuals

Abstract: Severely altered IL-7R expression was found in late presenters, and associations between IL-7R expression and thymic output after 24 months of suppressive cART indicate an impact of a IL-7 response for the long term de novo production from thymus.

Cited by 14 publications

References 38 publications

Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders

Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders

“Is a Bird in the Hand Worth 5 in the Bush?”: A Comparison of 3 Data-to-Care Referral Strategies on HIV Care Continuum Outcomes in San Francisco

Immune Disorders in HIV-Infected Patients Coinfected with Hepatitis C Virus

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