2018
DOI: 10.1016/j.resinv.2017.09.007
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Reduced incidence of lung cancer in patients with idiopathic pulmonary fibrosis treated with pirfenidone

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Cited by 60 publications
(48 citation statements)
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“…Interestingly, these growth factor receptors not only participate in IPF, but also in other proliferative diseases such as several malignancies, thus suggesting a protective role of pirfenidone for all of them. Indeed, pirfenidone has demonstrated anti-neoplastic effects in preclinical studies [54], as well as, it has been observed that the incidence of lung cancer in IPF patients treated with pirfenidone is significantly lower than in a non-pirfenidone IPF patient group [55].…”
Section: Figure 3: Pirfenidone (Pfd) Inhibits Muc1-ct Co-localizationmentioning
confidence: 99%
“…Interestingly, these growth factor receptors not only participate in IPF, but also in other proliferative diseases such as several malignancies, thus suggesting a protective role of pirfenidone for all of them. Indeed, pirfenidone has demonstrated anti-neoplastic effects in preclinical studies [54], as well as, it has been observed that the incidence of lung cancer in IPF patients treated with pirfenidone is significantly lower than in a non-pirfenidone IPF patient group [55].…”
Section: Figure 3: Pirfenidone (Pfd) Inhibits Muc1-ct Co-localizationmentioning
confidence: 99%
“…Antiproliferative effects and antitumor activity of pirfenidone and nintedanib may have a synergistic effect with current chemotherapeutic regimens, but further studies are needed [3,93,94]. A recent study suggests that pirfenidone therapy reduces the incidence of lung cancer [95]. Although there are no reference guidelines, annual lung cancer screening with low-dose CT in high-risk patients with IPF, especially those with CPFE and/or a heavy smoking history, could be considered [65,96].…”
Section: Lung Cancermentioning
confidence: 99%
“…Because TGF-β is a ubiquitous cytokine that is important in normal tissue homeostasis, selective TGF-β inhibition or localized/aerosolized drug delivery methods that target fibrotic fibroblasts may prove useful in combination with mTOR inhibitors [ 250 , 251 , 252 ]. Pirfenidone and nintedanib are both FDA approved for use in IPF with promising safety profiles [ 12 , 253 , 254 , 255 ]. Although the mechanism of action of pirfenidone is not completely understood, the antifibrotic effects are thought to occur indirectly through decreased TGF-β signaling, PI3K/AKT inhibition, and reduced mitochondrial ROS production, and decreased EMT [ 256 , 257 , 258 , 259 ].…”
Section: Therapeutic Targeting Of Mtor In Pulmonary Fibrosismentioning
confidence: 99%