Reduced Intrinsic Neural Timescales in Schizophrenia along Posterior Parietal and Occipital Areas

Uscatescu, Lavinia-Carmen; Said-Yürekli, Sarah; Kronbichler, Lisa; Stelzig-Schöler, Renate; Pearce, Brandy-Gale; Reich, Luise Antonia; Weber, Stefanie; Aichhorn, Wolfgang; Kronbichler, Martin

doi:10.1101/2021.05.22.21257646

Cited by 2 publications

(13 citation statements)

References 61 publications

(60 reference statements)

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“…In the present study, we aimed to replicate previous findings regarding the pattern of INT alterations in ASD and SZ reported by Watanabe et al (2019) and Uscătescu et al (2021), respectively. Both studies rely on the same computational approach to define the INT of resting-state fMRI time series.…”

supporting

confidence: 55%

“…The ROIs were defined as 6 mm radius spheres centered around the peak MNI coordinates reported by Watanabe et al (2019) and Uscătescu et al (2021). The peak coordinates of all 13 ROIs are shown in 3.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, we made the novel contribution of directly comparing ASD to SZ. Uscătescu et al (2021) previously reported five ROIs that showed a trend of decreased INT in SZ compared to TD (right occipital fusiform gyrus/U_rOccFusG, left superior occipital gyrus/U_lSupOccG, right superior occipital gyrus/U_rSupOccG, left lateral occipital cortex/U_lLatOccC, right post-central gyrus/U_rPostCenG), two of which were replicated across three independent datasets, namely the U_rSupOccG and the U_rPostCenG. In the present study, we found a similar pattern of decreased INT in SZ compared to TD in all five ROIs, but this difference was significant only for U_rSupOccG and the U_rPostCenG.…”

Section: Discussionmentioning

confidence: 99%

“…(note that regions derived fromWatanabe et al (2019) are prefixed with 'W' and those fromUscătescu et al (2021) with 'U').…”

mentioning

confidence: 99%

“…Peak MNI coordinates reported byWatanabe et al (2019) andUscătescu et al (2021), around which the ROIs of the current study were defined.…”

mentioning

confidence: 99%

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Intrinsic Neural Timescales in Autism Spectrum Disorder and Schizophrenia. A Replication and Direct Comparison Study

Uscătescu

Kronbichler

Said-Yürekli

et al. 2022

Preprint

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Intrinsic neural timescales (INT) reflect the duration for which brain areas store information. A posterior – anterior hierarchy of increasingly longer INT has been revealed in both typically developed individuals (TD), as well as patients diagnosed with autism spectrum disorder (ASD) and schizophrenia (SZ), though INT are, overall, shorter in both patient groups. In the present study, we attempted to replicate previously reported group differences by comparing INT of TD to ASD and SZ. We replicated the previously reported result showing reduced INT in the left lateral occipital gyrus and the right post-central gyrus in SZ compared to TD. For the first time, we also directly compared the INT of the two patient groups and found that these same two areas show significantly reduced INT in SZ compared to ASD. In ASD, significant correlations were found between INT and their clinical and phenotypic characteristics. Our results point to the left lateral occipital gyrus and the right post-central gyrus as holding potential for further diagnostic refinement of SZ.

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supporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…(note that regions derived fromWatanabe et al (2019) are prefixed with 'W' and those fromUscătescu et al (2021) with 'U').…”

mentioning

confidence: 99%

“…Peak MNI coordinates reported byWatanabe et al (2019) andUscătescu et al (2021), around which the ROIs of the current study were defined.…”

mentioning

confidence: 99%

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Intrinsic Neural Timescales in Autism Spectrum Disorder and Schizophrenia. A Replication and Direct Comparison Study

Uscătescu

Kronbichler

Said-Yürekli

et al. 2022

Preprint

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Abnormal intrinsic neural timescale and reduced grey matter volume in Parkinson’s disease

Wei

Zhang

Peng

et al. 2022

Preprint

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Background: The intrinsic neural timescale in a local brain area has been specialized, and the sensory and prefrontal areas have shorter and longer timescales, respectively. Parkinson's disease (PD) is a progressive neurological disorder that also exhibits with abnormal neural activity in sensorimotor, visual, and cognitive-related areas. However, it was unclear whether PD patients exhibited abnormal intrinsic timescales and whether PD patients exhibited different temporal feature at different stages. Methods: Here, we estimated the intrinsic timescales using the magnitude of the autocorrelation of intrinsic neural signals by resting state functional magnetic resonance imaging data in 74 PD patients, including 44 patients in the early stage (PD-ES) and 30 patients in the late stage (PD-LS), and 73 healthy controls (HC). Results: We identified that the PD group had shorter timescales in bilateral lingual and calcarine gyri, bilateral postcentral and precentral gyri, and the right middle cingulum gyrus than the HC group, which correlated with the age, but not in the HC group. Moreover, shorter timescales in the PD group also correlated with the symptom severity and reduced grey matter volume (GMV). Longer timescale in the right middle frontal gyrus was also found in the PD group than that in the HC group. Increasingly, compared to the HC group, the PD-ES group had longer timescales in the anterior cortical regions, including the left superior and inferior frontal gyri, and the right middle frontal gyrus, whereas the PD-LS group had shorter timescales in the posterior cortical regions, including bilateral calcarine and lingual gyri, which accompanied with more serious cognitive impairments and reduced GMV. Conclusions: Our findings suggest that PD patients exhibit abnormal intrinsic timescales in visual, sensorimotor, and cognitive systems, which might provide new insights for the neural substrate of PD. Distinct patterns of intrinsic timescales in cerebral cortex between the PD-LS and PD-ES groups indicate that intrinsic timescale might be a new neuroimaging biomarker across disease stage in PD.

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Reduced Intrinsic Neural Timescales in Schizophrenia along Posterior Parietal and Occipital Areas

Cited by 2 publications

References 61 publications

Intrinsic Neural Timescales in Autism Spectrum Disorder and Schizophrenia. A Replication and Direct Comparison Study

Intrinsic Neural Timescales in Autism Spectrum Disorder and Schizophrenia. A Replication and Direct Comparison Study

Abnormal intrinsic neural timescale and reduced grey matter volume in Parkinson’s disease

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