Reduced kidney branched chain aminotransferase expression in puromycin aminonucleoside-induced nephrotic syndrome

Ascencio, Claudia; Torres, Nimbe; Sandoval, Rosa Laura; Cruz, Cristino; Pedraza‐Chaverrí, José; Tovar, A R

doi:10.1016/s0024-3205(97)00959-4

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…In this study, it is assumed that the high alpha‐globulin in serum of the 18% CP group may indicate a risk of the syndromes, whilst limiting protein intake (14% CP diet) may ameliorate these syndromes. Accordingly, Ascencio et al. (1997) reported that low protein diets improved proteinuria and blood urea nitrogen, although they retarded production performance of animals (Harper 1984; Torres et al., 1998; Tovar et al., 1998; Bunchasak and Silapasorn, 2005).…”

Section: Discussionmentioning

confidence: 99%

Long-term feeding effects of dietary protein levels on egg production, immunocompetence and plasma amino acids of laying hens in subtropical condition

Poosuwan¹,

Bunchasak²,

Kaewtapee³

2010

Journal of Animal Physiology and Animal Nutrition

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The objective of this study was to determine the effect of protein levels on production performance, immune response, liver triglyceride and plasma amino acids profile of laying hens during 21-48 weeks of age. Two groups of commercial hens (Babcock B-308) were fed with diets with different crude protein levels (14% and 18% CP). The high protein diet (18% CP) significantly increased production performance, essential amino acid intake, spleen weight (% of body weight), ND-titre (haemagglutination-inhibition test), serum albumin (g/dl), serum alpha-globulin and plasma essential amino acids (except histidine) and decreased liver triglyceride (mg/g liver) in relation to the low protein diet (14% CP). In long-term effect, therefore, this study suggested that adequate dietary condition of amino acids, particularly methionine and branch-chain amino acids is necessary for sustaining normal immunocompetence and achieving maximum production performance.

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Section: Discussionmentioning

confidence: 99%

Long-term feeding effects of dietary protein levels on egg production, immunocompetence and plasma amino acids of laying hens in subtropical condition

Poosuwan¹,

Bunchasak²,

Kaewtapee³

2010

Journal of Animal Physiology and Animal Nutrition

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“…Dietary protein restriction has been shown to retard progression of renal disease in chronic renal insufficiency and to ameliorate proteinuria in nephrotic syndrome [17][18][19]. Likewise, administration of oral adsorbent, AST-120, has been reported to delay progression of renal insufficiency in humans with chronic renal failure [22,23], Imai rats with FGS, and rats with 5/6 nephrectomy [20,21,[24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

“…The effect of nephrotic syndrome in this model is compounded by the superimposed renal insufficiency, which has been shown to cause down-regulation of LPL, VLDL receptor, and LCAT, as well as up-regulation of hepatic ACAT-2 [12][13][14][15][16]. Dietary protein restriction has been shown to reduce proteinuria in nephrotic animals [17] and humans [18,19]. In addition, oral administration of AST-120 (AST) (an activated charcoal preparation) has been shown to slow progression of renal insufficiency in rats with 5/6 nephrectomy [20], in Imai rats with spontaneous FGS [21], as well as in humans with advanced chronic renal failure [22].…”

mentioning

confidence: 97%

Protein restriction and AST-120 improve lipoprotein lipase and VLDL receptor in focal glomerulosclerosis

Satô¹,

Liang²,

Vaziri³

2003

Kidney International

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A Soy Protein Diet Alters Hepatic Lipid Metabolism Gene Expression and Reduces Serum Lipids and Renal Fibrogenic Cytokines in Rats with Chronic Nephrotic Syndrome

Tovar

Murguía

Cruz

et al. 2002

The Journal of Nutrition

123

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Nephrotic syndrome (NS) is characterized by the presence of proteinuria and hyperlipidemia. However, ingestion of soy protein has a hypolipidemic effect. The present study was designed to determine whether the ingestion of a 20% soy protein diet regulates the expression of hepatic sterol regulatory element binding protein (SREBP)-1, fatty acid synthase (FAS), malic enzyme, beta-hydroxy-beta-methylglutaryl-CoA (HMG-CoA) reductase (r) and synthase (s), and LDL receptor (r), and to assess whether soy protein improves lipid and renal abnormalities in rats with chronic NS. Male Wistar rats were injected with vehicle or with puromycin aminonucleoside to induce NS and were fed either 20% casein or soy protein diets for 64 d. NS rats fed 20% soy protein had improved creatinine clearance and reduced proteinuria, hypercholesterolemia, hypertriglyceridemia, as well as VLDL-triglycerides and LDL cholesterol compared with NS rats fed the 20% casein diet. In addition, the soy protein diet decreased the incidence of glomerular sclerosis, and proinflammatory cytokines in kidney. Ingestion of the soy protein diet by control rats reduced the gene expression of SREBP-1, malic enzyme, FAS and increased HMG-CoAr, HMG-CoAs and LDLr. However, NS rats fed either casein or soy protein diets had low insulin concentrations with reductions in SREBP-1, FAS and malic enzyme expression compared with control rats fed the casein diet. NS rats fed the soy diet also had lower HMG-CoAr and LDLr mRNA levels than NS rats fed casein. In conclusion, the beneficial effects of soy protein on lipid metabolism are modulated in part by SREBP-1. However, in NS rats, the benefit may be through a direct effect of this protein on kidney rather than mediated by changes in expression of hepatic lipid metabolism genes.

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Reduced kidney branched chain aminotransferase expression in puromycin aminonucleoside-induced nephrotic syndrome

Cited by 3 publications

References 17 publications

Long-term feeding effects of dietary protein levels on egg production, immunocompetence and plasma amino acids of laying hens in subtropical condition

Long-term feeding effects of dietary protein levels on egg production, immunocompetence and plasma amino acids of laying hens in subtropical condition

Protein restriction and AST-120 improve lipoprotein lipase and VLDL receptor in focal glomerulosclerosis

A Soy Protein Diet Alters Hepatic Lipid Metabolism Gene Expression and Reduces Serum Lipids and Renal Fibrogenic Cytokines in Rats with Chronic Nephrotic Syndrome

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