Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries

Dhobale, Madhavi; Wadhwani, Nisha; Mehendale, Savita; Pisal, Hemlata; Joshi, Sadhana

doi:10.1016/j.plefa.2011.06.003

Cited by 50 publications

(30 citation statements)

References 38 publications

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“…In that study, placental DHA levels were lower (2.05±0.97 gm/100 gm of fatty acids, p<0.01, n = 58) in women delivering preterm compared to those delivering at term (3.19±0.94 gm/100 gm of fatty acids, n = 44) [21].…”

Section: Resultsmentioning

confidence: 70%

“…The associations between MMP and DHA levels were studied on this subset of term (n = 34) and preterm (n = 54) placental samples for which DHA levels were estimated in our previous study [21]. A negative association between placental MMP-9 and placental DHA (r = −0.213, p = 0.046, n = 88) was seen in the whole cohort (Figure 4a).…”

Section: Resultsmentioning

confidence: 86%

“…Our earlier studies in preterm deliveries indicate increased oxidative stress and reduced LCPUFA especially docosahexaenoic acid (DHA) levels in preterm pregnancy [20], [21].…”

Section: Introductionmentioning

confidence: 98%

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Matrix Metalloproteinase-1 and -9 in Human Placenta during Spontaneous Vaginal Delivery and Caesarean Sectioning in Preterm Pregnancy

et al. 2012

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Preterm birth is a major public health problem in terms of loss of life, long-term and short term disabilities worldwide. The process of parturition (both term and preterm) involves intensive remodelling of the extracellular matrix (ECM) in the placenta and fetal membranes by matrix metalloproteinases (MMPs). Our previous studies show reduced docosahexaenoic acid (DHA) in women delivering preterm. Further omega 3 fatty acids are reported to regulate MMP levels. This study was undertaken to examine the placental levels of MMPs and their association with placental DHA levels in women delivering preterm. The levels of MMP-1 and MMP-9 in 74 women delivering preterm (52 by spontaneous vaginal delivery and 22 by caesarean sectioning) and 75 women delivering at term (59 by spontaneous vaginal delivery and 16 by caesarean sectioning) were determined by enzyme-linked immunosorbent assay (ELISA) and their association with placental DHA was studied. Placental MMP-1 levels were higher (p<0.05) in women delivering preterm (both by spontaneous vaginal delivery and caesarean sectioning) as compared to those delivering at term. In contrast, placental MMP-9 levels in preterm pregnancies was higher (p<0.05) in women with spontaneous vaginal delivery while lower (p<0.05) in women delivering by caesarean sectioning. Low placental DHA was associated with higher placental MMP-9 levels. Our study suggests a differential effect of mode of delivery on the levels of MMPs from placenta. Further this study suggests a negative association of DHA and the levels of MMP-9 in human placenta although the mechanisms need further study.

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Section: Resultsmentioning

confidence: 70%

Section: Resultsmentioning

confidence: 86%

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Matrix Metalloproteinase-1 and -9 in Human Placenta during Spontaneous Vaginal Delivery and Caesarean Sectioning in Preterm Pregnancy

et al. 2012

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“…The associations between MMP/TIMP and DHA levels were studied on a subset of term (nZ38) and preterm (nZ56) women from this study for which placental DHA levels were estimated in our previous study (Dhobale et al 2011). In this study, a negative association between placental MMP2 levels and placental DHA levels was seen in the whole cohort (rZK0.353, PZ0.003, nZ94) and in the control group (rZK0.346, PZ0.033, nZ38) but not in the preterm group.…”

Section: Associations Of Placental Mmps and Timps With Placental Dha mentioning

confidence: 99%

Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites

Sundrani¹,

Chavan‐Gautam²,

Pisal³

et al. 2013

Reproduction

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Maternal nutrition is an important determinant of one-carbon metabolism and defects in the one-carbon metabolism may lead to poor obstetric outcomes. This study was designed to test the hypothesis that altered intake/metabolism of micronutrients (folic acid and vitamin B 12 ) and docosahexaenoic acid (DHA) contributes to increased homocysteine and oxidative stress leading to altered levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in women delivering preterm. We have earlier reported increased vitamin B 12 , homocysteine, and oxidative stress along with reduced placental DHA in women delivering preterm. In this study, we further examine the placental levels of MMP2, MMP3, TIMP1, and TIMP2 in 75 women delivering at term and 73 women delivering preterm. Placental levels of MMPs and TIMPs were determined by ELISA. Placental MMP2 and MMP3 levels were higher (P!0.01) in women delivering preterm as compared with term. There was no difference in the placental TIMP1 and TIMP2 levels in women delivering preterm and at term. Further placental MMP2 and MMP3 levels were higher (P!0.01) in women with preterm labor as compared with those in labor at term, suggesting that MMPs may favor degradation of extracellular matrix in the placenta during preterm labor. Our study for the first time suggests a crucial role of micronutrients and MMPs in preterm birth. Future studies need to examine if epigenetic modifications through the one-carbon cycle contribute to increased levels of MMPs leading to preterm deliveries.

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“…Whether this selective transport relies completely on the circulating maternal DHA stores or whether the placenta itself is involved in DHA synthesis is not known. Dhobale et al, have shown an association between placental weight and DHA concentration, and a correlation between placental weight and infant weight and length in preterm deliveries indicating that the DHA levels within the placenta effect fetal growth patterns [69]. More recent studies in animals have suggested that early DHA exposure influences neural differentiation, neurotransmitter target finding and synaptogenesis during gestation [20,70].…”

Section: Dha In Pregnancy and Early Childhoodmentioning

confidence: 99%

DHA supplementation: Current implications in pregnancy and childhood

Rogers

Valentine

Keim

2013

Pharmacological Research

107

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Dietary supplementation with (ω)-3 long chain fatty acids including docosahexaenoic acid (DHA) has increased in popularity in recent years and adequate DHA supplementation during pregnancy and early childhood is of clinical importance. Some evidence has been built for the neuro-cognitive benefits of supplementation with long chain polyunsaturated fatty acids (LCPUFA) such as DHA during pregnancy; however, recent data indicate that the anti-inflammatory properties may be of at least equal significance. Adequate DHA availability in the fetus/infant optimizes brain and retinal maturation in part by influencing neurotransmitter pathways. The anti-inflammatory properties of LCPUFA are largely mediated through modulation of signaling either directly through binding to receptors or through changes in lipid raft formation and receptor presentation. Our goal is to review the current findings on DHA supplementation, specifically in pregnancy and infant neurodevelopment, as a pharmacologic agent with both preventative and therapeutic value. Given the overall benefits of DHA, maternal and infant supplementation may improve neurological outcomes especially in vulernable populations. However, optimal composition of the supplement and dosing and treatment strategies still need to be determined to lend support for routine supplementation.

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Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries

Cited by 50 publications

References 38 publications

Matrix Metalloproteinase-1 and -9 in Human Placenta during Spontaneous Vaginal Delivery and Caesarean Sectioning in Preterm Pregnancy

Matrix Metalloproteinase-1 and -9 in Human Placenta during Spontaneous Vaginal Delivery and Caesarean Sectioning in Preterm Pregnancy

Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites

DHA supplementation: Current implications in pregnancy and childhood

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