Reduced long distance gamma (28–48Hz) coherence in euthymic patients with bipolar disorder

Özerdem, Ayşegül; Güntekin, Bahar; Atagün, Murat İlhan; Turp, Bilge; Başar, Erol

doi:10.1016/j.jad.2011.02.028

Cited by 97 publications

(41 citation statements)

References 44 publications

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“…The stronger mobilization or disinhibition, which implies a monitoring deficit, might act to compensate for the decreased neuronal activities when processing the octave illusion [62,63]. On the other hand, our results were opposite to those found in the manic phase of bipolar disorder patients [64,65], in which a long-distance coherence of the frontal-temporal areas was decreased during a cognitive task. We might speculate that the isolated activity of one cerebral area in response to a task without a synchronized activation of another as remote monitoring could easily result in manic behavior.…”

Section: Discussioncontrasting

confidence: 93%

EEG Theta Power and Coherence to Octave Illusion in First-Episode Paranoid Schizophrenia with Auditory Hallucinations

Zheng

Chai²,

Yu³

et al. 2014

Psychopathology

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Background: The exact mechanism behind auditory hallucinations in schizophrenia remains unknown. A corollary discharge dysfunction hypothesis has been put forward, but it requires further confirmation. Electroencephalography (EEG) of the Deutsch octave illusion might offer more insight, by demonstrating an abnormal cerebral activation similar to that under auditory hallucinations in schizophrenic patients. Methods: We invited 23 first-episode schizophrenic patients with auditory hallucinations and 23 healthy participants to listen to silence and two sound sequences, which consisted of alternating 400- and 800-Hz tones. EEG spectral power and coherence values of different frequency bands, including theta rhythm (3.5-7.5 Hz), were computed using 32 scalp electrodes. Task-related spectral power changes and task-related coherence differences were also calculated. Clinical characteristics of patients were rated using the Positive and Negative Syndrome Scale. Results: After both sequences of octave illusion, the task-related theta power change values of frontal and temporal areas were significantly lower, and the task-related theta coherence difference values of intrahemispheric frontal-temporal areas were significantly higher in schizophrenic patients than in healthy participants. Moreover, the task-related power change values in both hemispheres were negatively correlated and the task-related coherence difference values in the right hemisphere were positively correlated with the hallucination score in schizophrenic patients. Limitations: We only tested the Deutsch octave illusion in primary schizophrenic patients with acute first episode. Further studies might adopt other illusions or employ other forms of schizophrenia. Conclusion: Our results showed a lower activation but higher connection within frontal and temporal areas in schizophrenic patients under octave illusion. This suggests an oversynchronized but weak frontal area to exert an action to the ipsilateral temporal area, which supports the corollary discharge dysfunction hypothesis.

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Section: Discussioncontrasting

confidence: 93%

EEG Theta Power and Coherence to Octave Illusion in First-Episode Paranoid Schizophrenia with Auditory Hallucinations

Zheng

Chai²,

Yu³

et al. 2014

Psychopathology

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“…A number of neurological and psychiatric disorders are also characterized by interrupted or decreased gamma band activity (Garcia-Rill et al 2014). Aberrant gamma band activity and coherence during cognitive tasks or attentional load have been reported in schizophrenic and bipolar disorder patients (Flynn et al 2008; Ozerdem et al 2011; Spencer et al 2003; Symond et al 2005; Ulhaas and Singer 2010). It may be possible to use DBS, in cases resistant to pharmacotherapy, to attempt to normalize gamma band activity in these disorders.…”

Section: Suggestions For the Futurementioning

confidence: 98%

The physiology of the pedunculopontine nucleus: implications for deep brain stimulation

et al. 2014

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This brief review resolves a number of persistent conflicts regarding the location and characteristics of the mesencephalic locomotor region (MLR), which has in the past been described as not locomotion-specific and is more likely the pedunculopontine nucleus (PPN). The parameters of stimulation used to elicit changes in posture and locomotion we now know are ideally suited to match the intrinsic membrane properties of PPN neurons. The physiology of these cells is important not only because it is a major element of the reticular activating system (RAS), but also because it is a novel target for the treatment of gait and postural deficits in Parkinson’s disease (PD). The discussion explains many of the effects reported following deep brain stimulation (DBS) of the PPN by different groups, and provides guidelines for the determination of long-term assessment and effects of PPN DBS. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from DBS for movement disorders. Despite these improvements, there remains a great opportunity for further understanding of the mechanisms through which DBS has its effects and for further development of appropriate technology to effect these treatments. We review the scientific basis for one of the newest targets, the PPN, in the treatment of PD and other movement disorders, and address the needs for further investigation.

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“…Some of these studies have investigated such correlations in specific disorders such as, ADHD (Groom et al, 2010), bipolar disorder (Atagun et al, 2011;Chen et al, 2008b;Tan et al, 2014;O'Donnell et al, 2004;Özerdem et al, 2010;Özerdem et al, 2011), Alzheimer , first-episode psychosis (Flynn et al, 2008), mild cognitive impairment (Missonnier et al, 2006), Parkinson's disease (Hammond, Bergman, & Brown, 2007) or traumatic brain injury (Leon-Carrion et al, 2012). Other studies have shown the existence of this association between deficiencies in synchronization and various types of disorders, for example in Alzheimer's disease, mild cognitive impairment, attention, bipolar disorder and obsessive-compulsive disorder (Basar & Guntekin, 2013;Koenig et al, 2005;Leocani et al, 2001;.…”

Section: Synchronization and Mental Disordermentioning

confidence: 99%

Neural Binding, Consciousness, and Mental Disorders: Complexity as a Common Element

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2015

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Reduced long distance gamma (28–48Hz) coherence in euthymic patients with bipolar disorder

Cited by 97 publications

References 44 publications

EEG Theta Power and Coherence to Octave Illusion in First-Episode Paranoid Schizophrenia with Auditory Hallucinations

EEG Theta Power and Coherence to Octave Illusion in First-Episode Paranoid Schizophrenia with Auditory Hallucinations

The physiology of the pedunculopontine nucleus: implications for deep brain stimulation

Neural Binding, Consciousness, and Mental Disorders: Complexity as a Common Element

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