Reduced memory-related ongoing oscillatory activity in healthy older adults

Winterling, Signe L.; Shields, Stephanie M.; Rose, Michael

doi:10.1016/j.neurobiolaging.2019.03.012

Cited by 5 publications

(4 citation statements)

References 81 publications

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“…The present findings are in line with previous evidence of increases in theta power before stimulus presentation that were found to be related to more successful encoding of associative content 6 , 7 , 10 , 17 . Increases in theta power during encoding have been associated with better memory performance in experiments using SMEs before, especially when oscillatory data was gathered using non-invasive scalp EEG or MEG 10 .…”

Section: Discussionsupporting

confidence: 93%

“…This argument is supported by the positive relationship of SME magnitude and d ’ as a measure of memory performance found in this study. Similar results have been presented before in healthy adults 7 , supporting the assumption that fluctuations in pre-stimulus theta power might be considered behaviorally relevant. As the maximum effect in the present study was found in right lateral parietal regions, one could speculate about the effect’s origin in multisensory processing areas.…”

Section: Discussionsupporting

confidence: 89%

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Increases in pre-stimulus theta and alpha oscillations precede successful encoding of crossmodal associations

Ostrowski,

Rose

2024

Sci Rep

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A central aspect of episodic memory is the formation of associations between stimuli from different modalities. Current theoretical approaches assume a functional role of ongoing oscillatory power and phase in the theta band (3–7 Hz) for the encoding of crossmodal associations. Furthermore, ongoing activity in the theta range as well as alpha (8–12 Hz) and low beta activity (13–20 Hz) before the presentation of a stimulus is thought to modulate subsequent cognitive processing, including processes that are related to memory. In this study, we tested the hypothesis that pre-stimulus characteristics of low frequency activity are relevant for the successful formation of crossmodal memory. The experimental design that was used specifically allowed for the investigation of associative memory independent from individual item memory. Participants (n = 51) were required to memorize associations between audiovisual stimulus pairs and distinguish them from newly arranged ones consisting of the same single stimuli in the subsequent recognition task. Our results show significant differences in the state of pre-stimulus theta and alpha power between remembered and not remembered crossmodal associations, clearly relating increased power to successful recognition. These differences were positively correlated with memory performance, suggesting functional relevance for behavioral measures of associative memory. Further analysis revealed similar effects in the low beta frequency ranges, indicating the involvement of different pre-stimulus-related cognitive processes. Phase-based connectivity measures in the theta band did not differ between remembered and not remembered stimulus pairs. The findings support the assumed functional relevance of theta band oscillations for the formation of associative memory and demonstrate that an increase of theta as well as alpha band oscillations in the pre-stimulus period is beneficial for the establishment of crossmodal memory.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Increases in pre-stimulus theta and alpha oscillations precede successful encoding of crossmodal associations

Ostrowski,

Rose

2024

Sci Rep

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“…In older adults, such a comprehensive view integrating multiple findings of interacting oscillations during the formation of episodic memories is still missing. While some studies investigated the association of frequency bands or theta-gamma PAC with episodic (Crespo-Garcia et al, 2012; Després et al, 2017; Karlsson et al, 2022; Karlsson and Sander, 2023; Karlsson et al, 2020; Lithfous et al, 2015; Sander et al, 2020; Strunk and Duarte, 2019; Winterling et al, 2019) or working memory (Reinhart and Nguyen, 2019), the aging related effects have not been investigated specifically with respect to sequence memory.…”

Section: Introductionmentioning

confidence: 99%

Brain oscillatory processes related to sequence memory in healthy older adults

Ehrhardt,

Flöel,

et al. 2023

Preprint

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Sequence memory is subject to age-related decline, but the underlying processes are not yet fully understood. We analyzed electroencephalography (EEG) in 21 healthy older (60-80 years) and 26 young participants (20-30 years) and compared time-frequency spectra and theta-gamma phase-amplitude-coupling (PAC) during encoding of the order of visually presented items. In older adults, desynchronization in theta (4-8 Hz) and synchronization in gamma (30-45 Hz) power did not distinguish between subsequently correctly and incorrectly remembered trials, while there was a subsequent memory effect for young adults. Theta-gamma PAC was modulated by item position within a sequence for older but not young adults. Specifically, position within a sequence was coded by higher gamma amplitude for successive theta phases for later correctly remembered trials. Thus, deficient differentiation in theta desynchronization and gamma oscillations during sequence encoding in older adults may reflect neurophysiological correlates of age-related memory decline. Furthermore, our results indicate that sequences are coded by theta-gamma PAC in older adults, but that this mechanism might lose precision in aging.

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“…Aging is associated with impaired hippocampal-dependent learning characterized by reduced theta oscillations [ 20 , 21 ]. Theta oscillations rely upon the supply and reuptake of cholinergic input and are critical for novel learning and memory processes, e.g., encoding/recognition, working memory, and episodic memory [ 22 , 23 ]. For instance, memory recollection tasks in older adults show reductions in theta and beta oscillatory power during stimulus processing, and post-stimulus theta activity positively correlates with episodic memory performance [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Music and Visual Art Training Increase Auditory-Evoked Theta Oscillations in Older Adults

et al. 2022

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Music training was shown to induce changes in auditory processing in older adults. However, most findings stem from correlational studies and fewer examine long-term sustainable benefits. Moreover, research shows small and variable changes in auditory event-related potential (ERP) amplitudes and/or latencies in older adults. Conventional time domain analysis methods, however, are susceptible to latency jitter in evoked responses and may miss important information of brain processing. Here, we used time-frequency analyses to examine training-related changes in auditory-evoked oscillatory activity in healthy older adults (N = 50) assigned to a music training (n = 16), visual art training (n = 17), or a no-treatment control (n = 17) group. All three groups were presented with oddball auditory paradigms with synthesized piano tones or vowels during the acquisition of high-density EEG. Neurophysiological measures were collected at three-time points: pre-training, post-training, and at a three-month follow-up. Training programs were administered for 12-weeks. Increased theta power was found pre and post- training for the music (p = 0.010) and visual art group (p = 0.010) as compared to controls (p = 0.776) and maintained at the three-month follow-up. Results showed training-related plasticity on auditory processing in aging adults. Neuroplastic changes were maintained three months post-training, suggesting music and visual art programs yield lasting benefits that might facilitate encoding, retention, and memory retrieval.

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Reduced memory-related ongoing oscillatory activity in healthy older adults

Cited by 5 publications

References 81 publications

Increases in pre-stimulus theta and alpha oscillations precede successful encoding of crossmodal associations

Increases in pre-stimulus theta and alpha oscillations precede successful encoding of crossmodal associations

Brain oscillatory processes related to sequence memory in healthy older adults

Music and Visual Art Training Increase Auditory-Evoked Theta Oscillations in Older Adults

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