Reduced mortality and faster treatment in sepsis seen at freestanding vs. hospital-based emergency departments

Griffin, Gregory; Smalley, Courtney M.; Fertel, Baruch S.; Mo, Kevin; Krizo, Jessica; Mangira, Caroline; Simon, Erin L.

doi:10.1016/j.ajem.2022.02.005

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…It is considered an important indicator for predicting the prognosis of severe symptomatic diseases. [ 22 ] Research has shown that PCT and RDW have fast and sensitive characteristics in detecting inflammation, and have been widely used in the detection of PS. Therefore, this study will use PCT and RDW for the diagnosis and prognosis evaluation of PS to provide more accurate reference basis for the treatment and prognosis of children.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of PCT and RDW in premature infants with septicemia

Xu,

Ca,

Zhou

2024

Medicine

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It aims to study the diagnostic effect of procalcitonin (PCT) and red blood cell distribution width (RDW) in premature septicemia (PS), and to analyze the prognostic evaluation value of PCT and RDW in PS. Ninety eight septicemia premature infants (SPI) who visited the neonatal intensive care unit of our hospital from June 2019 to July 2021 were selected and met the criteria. Based on the patient’s condition and the neonatal shock score, they were separated into a severe group (SG) and a mild group (MG). There were 43 children and 55 children in the 2 groups, respectively. According to the survival status of SPI after 3 days of treatment, they were divided into a death group and a SG. It detected and analyzed the peripheral venous blood of SPI before treatment (BT) and after treatment (AT), and observed the changes of PCT and RDW. The comparison of general data between severe and mild SPI and their mothers did not have statistical significance (P > .05). The PCT of the SG was higher than that of the MG BT, on the 1st day and the 3rd day AT; The PCT BT and AT in both groups ranged from high to low on the 1st day and the 3rd day AT and BT (P < .05). The RDW in the SG were higher than those in the MG, and the RDW BT and AT in both groups were the highest on the 1st day AT; The RDW BT in the MG was higher than on the 3rd day AT, while the RDW BT in the SG was lower than on the 3rd day AT (P < .05). The optimal cutoff values for PCT on the 1st and 3rd day AT were 40.594ng/ml and 64.854ng/ml, respectively, with sensitivity of 100.0% and 100.0%, and specificity of 73.2% and 87.1% (P < .05). The optimal cutoff values for RDW on the 1st and 3rd day AT were 16.649% and 18.449%, respectively, with sensitivity of 100.0% and 100.0%, and specificity of 68.5% and 91.8% (P < .05). Monitoring the changes in PCT and RDW can promote the early diagnosis of PS and their prognosis evaluation.

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Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of PCT and RDW in premature infants with septicemia

Xu,

Ca,

Zhou

2024

Medicine

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“…An uncontrolled infectious process is the cause of sepsis and involves a struggle between the infectious agent and the immune system, generating a systemic inflammatory state. Sepsis due to peritonitis is usually triggered after an anastomotic dehiscence following colorectal surgery [ 1 ] and is associated with morbidity and mortality [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Study of the Effect of Wild-Type and Transiently Expressing CXCR4 and IL-10 Mesenchymal Stromal Cells in a Mouse Model of Peritonitis

Garcia Gómez-Heras,

Garcia-Arranz,

Vega-Clemente

et al. 2023

IJMS

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Sepsis due to peritonitis is a process associated with an inflammatory state. Mesenchymal stromal cells (MSCs) modulate the immune system due to the paracrine factors released and may be a therapeutic alternative. Three treatment groups were developed in a murine model of peritonitis to verify the effect of human adipose mesenchymal stem cell (hASCs). Additionally, a temporary modification was carried out on them to improve their arrival in inflamed tissues (CXCR4), as well as their anti-inflammatory activity (IL-10). The capacity to reduce systemic inflammation was studied using a local application (peritoneal injection) as a treatment route. Comparisons involving the therapeutic effect of wild-type ASCs and ASCs transiently expressing CXCR4 and IL-10 were carried out with the aim of generating an improved anti-inflammatory response for sepsis in addition to standard antibiotic treatment. However, under the experimental conditions used in these studies, no differences were found between both groups with ASCs. The peritoneal administration of hASCs or genetically modified hASCs constitutes an efficient and safe therapy in our model of mouse peritonitis.

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Virtual triage from freestanding emergency departments: a propensity score-weighted analysis of short-term outcomes in emergency general surgery

et al. 2023

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Reduced mortality and faster treatment in sepsis seen at freestanding vs. hospital-based emergency departments

Cited by 5 publications

References 13 publications

Diagnostic and prognostic value of PCT and RDW in premature infants with septicemia

Diagnostic and prognostic value of PCT and RDW in premature infants with septicemia

Study of the Effect of Wild-Type and Transiently Expressing CXCR4 and IL-10 Mesenchymal Stromal Cells in a Mouse Model of Peritonitis

Virtual triage from freestanding emergency departments: a propensity score-weighted analysis of short-term outcomes in emergency general surgery

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