Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits

Abstract

Our data suggest that decreased M3 receptor-mediated parotid secretion in diabetic rabbits appears to be due to alterations in NO signaling, mainly due to iNOS induction, accompanied by elevated antioxidant response.

Melatonin Action in Type 2 Diabetic Parotid Gland and Dental Pulp: In Vitro and Bioinformatic Findings

“…In diabetes, oxidative-nitrosative stress occurs due to persistent hyperglycemia, which induces a sequence of events that generate excessive production of reactive oxygen (ROS) and nitrogen species (RNS) [11]. Oxidative stress and inflammation are closely interconnected processes in diabetes, leading to endothelial dysfunction and damage to cellular components and signaling, resulting in oral tissue function deterioration in diabetes [3,[12][13][14][15] (Figure 1). In the Report of the Institute for Public Health of Serbia, "Dr. Milan Jovanović Batut" from 2020, it was announced that in the Republic of Serbia, seven hundred thousand people suffer from DM and that in 2040, every fifth citizen of Serbia will have DM.…”

“…In diabetes, oxidative-nitrosative stress occurs due to persistent hyperglycemia, which induces a sequence of events that generate excessive production of reactive oxygen (ROS) and nitrogen species (RNS) [11]. Oxidative stress and inflammation are closely interconnected processes in diabetes, leading to endothelial dysfunction and damage to cellular components and signaling, resulting in oral tissue function deterioration in diabetes [3,[12][13][14][15] (Figure 1). As oral homeostasis is closely related to overall psycho-physical health, as well as to the maintenance of optimal glycemia, new therapeutic strategies targeting diabetes-induced oxidative stress and establishing oral homeostasis in patients with T2DM is of particular importance [16].…”

“…In diabetes, oxidative–nitrosative stress occurs due to persistent hyperglycemia, which induces a sequence of events that generate excessive production of reactive oxygen (ROS) and nitrogen species (RNS) [ 11 ]. Oxidative stress and inflammation are closely interconnected processes in diabetes, leading to endothelial dysfunction and damage to cellular components and signaling, resulting in oral tissue function deterioration in diabetes [ 3 , 12 , 13 , 14 , 15 ] ( Figure 1 ).…”