Reduced neurogenesis in the rat hippocampus following high fructose consumption

Borght, Karin van der; Köhnke, Rickard; Göransson, Nathanael; Deierborg, Tomas; Brundin, Patrik; Erlanson–Albertsson, Charlotte; Lindqvist, Andreas

doi:10.1016/j.regpep.2010.11.002

Cited by 99 publications

(78 citation statements)

References 31 publications

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“…In accordance with the present results, Van der Borght et al, Ueno et al and Axelsen et al [5,29,30] showed that consumption of fructose could not affect the insulin, free fatty acid and glucose lev els in fasting state. The controversial findings are reported as well [4,7,2729,32].…”

Section: Discussionsupporting

confidence: 93%

“…Contrary to their claim, in this study, no weight gain and change in liquid intake was observed. The finding of the pres ent research is in the same line with those of Taka tori et al, Van der Borght et al and Zamami et al [28,30,32]. A probable description might be a differ ent route of administration.…”

Section: Discussionsupporting

confidence: 87%

“…It has been shown that consumption of a high caloric diet has harmful con sequences for synaptic plasticity [31]. Also, a high caloric diet impairs the cognitive function, memory, dendritic spine density, synaptic plasticity [26,27] and neurogenesis in the hippocampus [30].…”

Section: Introductionmentioning

confidence: 99%

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Original article High fructose solution induces neuronal loss in the nucleus of the solitary tract of rats

Rafati¹,

Anvari²,

Noorafshan³

2013

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 87%

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Original article High fructose solution induces neuronal loss in the nucleus of the solitary tract of rats

Rafati¹,

Anvari²,

Noorafshan³

2013

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“…Further studies evoked that the proinflammatory cytokineslike IL-1β, IL-6 or TNF-α alter the hippocampal neurogenesis and synapto genes is processes which are essential for memory formation [47] [48] [49]. For instance, four weeks for fructose or sucrose diet but not free glucose, neurogenes is in the hippocampus was reduced to approximately 40% [50]. That reinforces the hypothesis about HFD which impairs memory through the slowdown of neurogenesis.…”

Section: Discussionsupporting

confidence: 57%

Methyl Donors Supplementation Attenuates the Adverse Effects of Maternal High Fructose Diet of Offspring Emotional and Cognitive Behaviors

Coulibaly¹,

Mesfioui²,

Ouichou³

et al. 2017

OJEMD

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Free Fatty acid is an end-product of hepatic metabolism of fructose. Most of past studies have demonstrated significant relationship between gestational high fat diet and metabolic and physiology outcomes in offspring. However, there is a scarce of data extended to the effects of high fructose diet-fed dams on juveniles' progeny. Therefore, the present experiment was designed to examine the later effects of maternal high fructose diet intake during pregnancy and lactation on juvenile offspring rats emotional behaviors and memory abilities. We tested whether methyl donors supplemented to that high fructose diet could reverse the adverse effects. We found at two months of age, anxiety-like behavior and depression-like behavior were elevated in off springs of mother fed to high fructose diet and a sex difference effect with males were more affected than females. In addition, behavioral outcomes indicated that the high fructose diet also impaired spatial working and recognition memories in the Y-maze and object recognition test respectively. Blood glucose intolerance increased significantly in juvenile males rats of dams fed with high fructose diet when compared to females. However, a supplementation of the maternal diet with methyl donors attenuated all these changes. Our study suggested a controlled fructose diet supplemented to methyl donors during critical period of brain developing (in utero and pre-weaning stage), otherwise that could induced irreversible detrimental effects on offspring behavior and cognitive health.

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“…It is not wise to administer sugary beverages to dogs for the purposes of increasing persistence on a regular basis, as the chronic consumption of sugars has been linked to long-term neurodegeneration and decreased executive function (van der Borght et al, 2011;Ross et al, 2009). Thus, it would be useful if the results obtained here motivated research on the effects of other nutrients (that similarly activate the vagus nerve) on replenishment.…”

Section: Discussionmentioning

confidence: 99%

Self-regulatory depletion in dogs: Insulin release is not necessary for the replenishment of persistence

Miller

Pattison

Laude

et al. 2015

Behavioural Processes

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It has been hypothesized that self-control is constrained by a limited energy resource that can be depleted through exertion. Once depleted, this resource can be replenished by the consumption or even the taste of glucose. For example, the need to inhibit reduces subsequent persistence at problem solving by humans and dogs, an effect that is not observed when a glucose drink (but not placebo) is administered following initial inhibition. The mechanism for replenishment by glucose is currently unknown. Energy transfer is not necessary, though insulin secretion may be involved. This possibility was investigated in the current study by having dogs exert self-control (sit-stay) and subsequently giving them (1) glucose that causes the release of insulin, (2) fructose that does not result in the release of insulin nor does it affect glucose levels (but is a carbohydrate), or (3) a calorie-free drink. Persistence measures indicated that both glucose and fructose replenished canine persistence, whereas the calorie-free drink did not. These results indicate that insulin release is probably not necessary for the replenishment that is presumed to be responsible for the increase in persistence.(182 words)

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Reduced neurogenesis in the rat hippocampus following high fructose consumption

Cited by 99 publications

References 31 publications

Original article High fructose solution induces neuronal loss in the nucleus of the solitary tract of rats

Original article High fructose solution induces neuronal loss in the nucleus of the solitary tract of rats

Methyl Donors Supplementation Attenuates the Adverse Effects of Maternal High Fructose Diet of Offspring Emotional and Cognitive Behaviors

Self-regulatory depletion in dogs: Insulin release is not necessary for the replenishment of persistence

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