2018
DOI: 10.1097/mph.0000000000001015
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Reduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of Infections

Abstract: Data on the production of neutrophil extracellular traps (NETs) in leukemia patients are scant. Phagocytosis, hydrogen peroxide, neutrophil elastase and myeloperoxidase enzymatic activity as well as NETs formation were studied in 10 pediatric acute lymphoblastic leukemia and 7 pediatric acute myeloid leukemia (AML) patients after induction chemotherapy. Median neutrophil elastase activity and NETs formation were lower in AML versus acute lymphoblastic leukemia (41% vs. 90%, P=0.005 and 51% vs. 94%, P=0.008, re… Show more

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Cited by 9 publications
(8 citation statements)
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“…In our material, NETs release was decreased in neutrophils isolated from both AML and ALL patients at the moment of diagnosis ( Figure 1 and Figure 2 ). However, the ability to release NETs was improved in some patients who responded to induction therapy ( Figure 3 A), consistent with the previous observations made by Berger-Achituv and Elhasid [ 28 ], but not in those who did not achieve remission after 30 days of treatment ( Figure 3 A).…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…In our material, NETs release was decreased in neutrophils isolated from both AML and ALL patients at the moment of diagnosis ( Figure 1 and Figure 2 ). However, the ability to release NETs was improved in some patients who responded to induction therapy ( Figure 3 A), consistent with the previous observations made by Berger-Achituv and Elhasid [ 28 ], but not in those who did not achieve remission after 30 days of treatment ( Figure 3 A).…”
Section: Discussionsupporting
confidence: 90%
“…In a small population of children with AML ( n = 7) and ALL ( n = 10) who underwent induction therapy, Berger-Achituv and Elhasid have shown that neutrophils isolated from AML patients are characterized by decreased neutrophil elastase (NE) activity and low ability to form NETs after ex vivo stimulation with PMA [ 28 ]. Although they suggested that ALL patients did not exhibit marked decrease in NETs formation, a more detailed inspection of their data shows that in 4 out of 10 ALL patients, NETs release and NE activity were visibly decreased as compared to healthy controls [ 28 ]. In our material, NETs release was decreased in neutrophils isolated from both AML and ALL patients at the moment of diagnosis ( Figure 1 and Figure 2 ).…”
Section: Discussionmentioning
confidence: 99%
“…Routine antimicrobial prophylaxis (in some countries) and early identification of signs and symptoms related to sepsis in immunocompromised patients increase survival in children with AML ( 18 , 19 ).…”
Section: Discussionmentioning
confidence: 99%
“…[29,47] We also observed low levels of H3Cit-DNA complexes in leukemia patients This is consistent with previous studies demonstrating that granulocytes and neutrophils from acute leukemia patients have reduced capacity to form NETs compared to those from healthy controls. [54][55][56] It is also notable that APL patients had lower WBC counts that might also affect the levels of H3Cit-DNA complexes in APL patients.…”
Section: Discussionmentioning
confidence: 99%