Reduced oxygen diffusion across the shell of Gray gull (Larus modestus) eggs

Monge, Carlos; Ostojic, Hrvoj; Aguilar, Roberto; Cifuentes,

doi:10.4067/s0716-97602000000300007

Cited by 6 publications

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“…Birds and reptiles are adapted for terrestrial growth, with the allantois and amniotic membranes that provide additional gas exchange protection. Egg shell traits are specific to habitat, demonstrated by the high-altitude gray gull (Larus modestus), which trades oxygen diffusion and hypoxic potential for enhanced water conservation (Monge et al 2000). Similarly, localized shell permeability is associated with altered yolk sac development and vascularization in gekkotan lizards (Andrews et al 2013).…”

Section: Lipid Peroxidation and Cell Death In Nonmammalian Vertebratesmentioning

confidence: 99%

Regulation of lipid peroxidation and ferroptosis in diverse species

et al. 2018

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Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.

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Section: Lipid Peroxidation and Cell Death In Nonmammalian Vertebratesmentioning

confidence: 99%

Regulation of lipid peroxidation and ferroptosis in diverse species

et al. 2018

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“…This lower permeability reduces water vapor loss, but also inhibits inward oxygen diffusion, resulting in lower oxygen consumption and much longer incubation time in the Gray gull compared to other gulls. These experiments reveal the relationship between gas diffusion, egg shell conductance, and development in a model chosen for its location, rather than its taxonomy (Monge et al, 2000 ).…”

Section: Alternative Avian Models For Research In Developmentmentioning

confidence: 99%

Beyond the Chicken: Alternative Avian Models for Developmental Physiological Research

Flores-Santin

Burggren

2021

Front. Physiol.

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Biomedical research focusing on physiological, morphological, behavioral, and other aspects of development has long depended upon the chicken (Gallus gallus domesticus) as a key animal model that is presumed to be typical of birds and generally applicable to mammals. Yet, the modern chicken in its many forms is the result of artificial selection more intense than almost any other domesticated animal. A consequence of great variation in genotype and phenotype is that some breeds have inherent aberrant physiological and morphological traits that may show up relatively early in development (e.g., hypertension, hyperglycemia, and limb defects in the broiler chickens). While such traits can be useful as models of specific diseases, this high degree of specialization can color general experimental results and affect their translational value. Against this background, in this review we first consider the characteristics that make an animal model attractive for developmental research (e.g., accessibility, ease of rearing, size, fecundity, development rates, genetic variation, etc.). We then explore opportunities presented by the embryo to adult continuum of alternative bird models, including quail, ratites, songbirds, birds of prey, and corvids. We conclude by indicating that expanding developmental studies beyond the chicken model to include additional avian groups will both validate the chicken model as well as potentially identify even more suitable avian models for answering questions applicable to both basic biology and the human condition.

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“…The large diffusion barrier across the bird egg has been well documented (e.g. Pettit and Whittow, 1982;Rahn et al, 1987;Meir et al, 1999;Monge et al, 2000;Wagner-Amos and Seymour, 2002). Acute exposure to hyperoxia increases the P O 2 gradient and subsequently increases O 2 diffusion across the egg shell.…”

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confidence: 99%

`Blood-doping' effects on hematocrit regulation and oxygen consumption in late-stage chicken embryos (Gallus gallus)

Khorrami

Tazawa

Burggren

2008

Journal of Experimental Biology

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SUMMARYThe extent to which hematocrit (Hct) is regulated and the impact of altered Hct on blood oxygen transport in avian embryos are largely unknown. Consequently, we investigated how acute blood removal or Ringer solution injection modified Hct in day·15 embryos, and how ʻblood dopingʼ with erythrocyte-enriched whole blood influenced O 2 consumption in day·15-17 chicken embryos. Mean Hct (±s.e.m.) at day·15, 16 and 17 was 26.7±0.6%, 28.0±0.4% and 30.7±0.5%, respectively. Blood withdrawal (19 increments of 125·l each, separated by 30·min) caused a progressive fall in Hct to ~12% at day·15. Hct decline was strictly proportional to the extent of blood withdrawal. Incremental Ringer solution injection over an 8·h period, transiently increasing blood volume up to 85% over initial values, did not decrease Hct, indicating that injected Ringer solution rapidly left the circulating blood compartment. Blood doping with erythrocyte-enriched whole blood artificially elevated Hct from 27% to 38%, but caused no significant change in routine O 2 consumption (0.35-0.39·ml O 2 ·min -1 ·egg -1 ) at any point over the subsequent 6·h period in day·15-17 embryos. We conclude that Hct is not protected acutely in day·15 chicken embryos, with no evidence of erythrocyte sequestration or release. Additionally, at day·15-17, Hct increases of ~10% do not enhance embryonic oxygen consumption, suggesting that blood oxygen carrying capacity per se is not limiting to oxygen consumption.Key words: hematocrit, oxygen consumption, blood volume, development, embryo. THE JOURNAL OF EXPERIMENTAL BIOLOGY884 humidity of 60%. Eggs were turned automatically every hour. A total of 287 eggs were used in this study. Egg mass ranged from 51.07 to 77.33·g (mean ± 1 s.e.m., 58.7±0.37·g). Venous cannulation for Hct manipulationFor withdrawal or infusion of blood or Ringer solution, a vein in the chorioallantoic membrane (CAM) was cannulated with a method adapted from that of Tazawa et al. . Briefly, each egg was candled to find the largest CAM vein at the egg's blunt end. The egg was then half-buried in a sand bath set at 38°C to maintain egg temperature throughout surgery. A piece of eggshell (~4·mm in diameter) above the selected vein was removed. The inner eggshell membrane was carefully removed to reveal the underlying vein, which was then non-occlusively cannulated in a downstream direction. The cannula comprised a 30·gauge needle, bent at 90° approximately 2·mm from the tip, which was glued into 100·mm of PE·10 tubing, which in turn was glued into 100·mm of PE·50 tubing. Prior to its insertion, the cannula was filled with heparinized (100·units·ml The open end of the cannula was then closed with a small stainless steel pin. The egg was returned to the incubator (at 38°C) immediately after cannula implantation. Hct determinationHct was determined on 25·l of undiluted blood drawn into a Hamilton syringe through the implanted cannula. Blood volume in day·15 embryos is ~2.5·ml (see Tazawa and Whittow, 2000), so the volume of this blood sample represents ~1...

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Reduced oxygen diffusion across the shell of Gray gull (Larus modestus) eggs

Cited by 6 publications

References 0 publications

Regulation of lipid peroxidation and ferroptosis in diverse species

Regulation of lipid peroxidation and ferroptosis in diverse species

Beyond the Chicken: Alternative Avian Models for Developmental Physiological Research

`Blood-doping' effects on hematocrit regulation and oxygen consumption in late-stage chicken embryos (Gallus gallus)

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