Reduced perfusion density of superficial retinal capillary plexus after intravitreal ocriplasmin injection for idiopathic vitreomacular traction

Iuliano, Lorenzo; Fogliato, Giovanni; Colombo, Roberta; Sacconi, Riccardo; Querques, Giuseppe; Bandello, Francesco; Codenotti, Marco

doi:10.1186/s12886-019-1119-9

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…We observed complete VMT resolution in 55% of our case series. These data agree with previous investigations assessing the percentages of patients showing VMT resolution after ocriplasmin treatment 8,9 .…”

Section: Discussionsupporting

confidence: 93%

Vitreomacular traction quantitative cutoffs for the assessment of resolution after ocriplasmin intravitreal treatment

Arrigo

Calamuneri

Bordato

et al. 2020

Sci Rep

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This study aimed to assess optical coherence tomography (OCT) parameters associated with vitreomacular traction (VMT) resolution after ocriplasmin intravitreal injection and also associated with the development of vitreomacular complications. Study designed was a retrospective case series. Structural OCT images were acquired at baseline and over the follow-up after treatment. We developed a mathematical model to provide quantitative parameters associated with VMT resolution. Moreover, we adopted the same model to assess the quantitative parameters associated with development of further vitreomacular complications or with the worsening of the coexisting condition. Main outcome measures were BCVA, central macular thickness (CMT), VMT reflectivity, VMT size, VMT resolution, epiretinal membrane (ERM), macular holes. 73 eyes of 73 VMT patients (mean age 73 ± 9 years) were recruited. The mean follow-up duration was 2.6 ± 1.1 years. Mean baseline BCVA was 0.38 ± 0.18 LogMAR, improving to 0.26 ± 0.20 at the end of the follow-up (p < 0.01). Baseline CMT was 431 ± 118 µm, improving to 393 ± 122 µm at the end of the follow-up (p < 0.01). 38/73 eyes (52%) showed only VMT, whereas 35/73 eyes (48%) also showed coexisting alterations at baseline. VMT resolved in 40/73 eyes (55% of cases). Our model disclosed VMT reflectivity as the most involved parameter in VMT resolution. VMT size showed less influence on the success of ocriplasmin treatment. ERM was negatively associated with VMT resolution. Moreover, VMT reflectivity values and ERM represented the most important parameters for the onset of vitreomacular complications.

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Section: Discussionsupporting

confidence: 93%

Vitreomacular traction quantitative cutoffs for the assessment of resolution after ocriplasmin intravitreal treatment

Arrigo

Calamuneri

Bordato

et al. 2020

Sci Rep

Self Cite

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Choriocapillaris: Fundamentals and advancements

Lejoyeux

Benillouche

Ong

et al. 2022

Progress in Retinal and Eye Research

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Pneumatic vitreolysis versus vitrectomy for the treatment of vitreomacular traction syndrome and macular holes: complication analysis and systematic review with meta-analysis of functional outcomes

Quiroz-Gonzalez

Lima-Gómez

2023

Int J Retin Vitr

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Background We conducted a systematic review to compare the effects of pneumatic vitreolysis (PV), enzymatic vitreolysis (EVL) with ocriplasmin, and pars plana vitrectomy (PPV) on vitreomacular traction (VMT) syndrome and macular holes (MHs) to assess their efficacy as treatment options. Methods Databases, including PubMed, ClinicalTrials.gov (www.clinicaltrials.gov), the Cochrane Central Register of Controlled Trials (CENTRAL)—including the Cochrane Eyes and Vision Group Trials Register (The Cochrane Library 2013, Issue 2)—, Ovid MEDLINE, and EMBASE (January 2000–October 2022), were searched to identify studies comparing the outcomes of PV versus PPV, PPV versus ocriplasmin and ocriplasmin versus PV. RevMan 5.1 was used for the meta-analysis of the studies. Results Among the 89 studies, 79 were considered eligible for qualitative analysis, and 10 quantitative studies were subjected to meta-analysis. PPV resulted in better postoperative visual acuity improvement than ocriplasmin (standardized mean deviation (SMD) = 0.38, 95% CI 0.03–0.73, p = 0.0003). PV resulted in no significant difference in visual improvement compared with PPV (SMD = − 0.15, 95% CI − 0.47 to 0.16, p = 0.35). PPV was significantly more effective in terms of the VMT release rate (risk ratio = 0.48, 95% CI 0.38–0.62, p = 0.00001) and MH closure rate (risk ratio = 0.49, 95% CI 0.30–0.81, p = 0.006) than ocriplasmin. PV was more effective than ocriplasmin in terms of the VMT release rate (risk ratio = 0.49, 95% CI 0.35–0.70, p = 0.0001). Qualitative analysis showed MH closure rates of 46%, 47.8%, and 95% and VMT releases rates of 46%, 68% and 100% after ocriplasmin, PV, and PPV treatments, respectively. Adverse events and postoperative complications occurring after treatment have also been documented in these studies. Conclusion PPV appears to be the most promising option for MH closure and VMT release, with fewer serious complications than EVL or PV. However, given the limited number of studies comparing these treatments, further research is needed to establish the superiority of PPV over the other options.

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Reduced perfusion density of superficial retinal capillary plexus after intravitreal ocriplasmin injection for idiopathic vitreomacular traction

Cited by 3 publications

References 29 publications

Vitreomacular traction quantitative cutoffs for the assessment of resolution after ocriplasmin intravitreal treatment

Vitreomacular traction quantitative cutoffs for the assessment of resolution after ocriplasmin intravitreal treatment

Choriocapillaris: Fundamentals and advancements

Pneumatic vitreolysis versus vitrectomy for the treatment of vitreomacular traction syndrome and macular holes: complication analysis and systematic review with meta-analysis of functional outcomes

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