Reduced physiologic complexity is associated with poor sleep in patients with major depression and primary insomnia

Yang, Albert C.; Tsai, Shih‐Jen; Yang, Cheng; Kuo, Chung Hsun; Chen, Tai Jui; Chen, Hong

doi:10.1016/j.jad.2010.11.030

Cited by 101 publications

(111 citation statements)

References 38 publications

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“…These studies support the idea that sleep may play a role in the link between CVC and depressive symptoms by showing, for example, links between reduced sleep quality and reduced CVC in depressed but not in healthy individuals (Yang et al, 2011). One study directly tested the model we propose here, whereby CVC and sleep quality interact in predicting depressive symptoms.…”

Section: Sleep As a Moderator Of The Link Between Cvc And Depressive supporting

confidence: 70%

“…Thus, they provide a biopsychosocial framework for interpreting CVC differences in, for example, mood disorders (Rottenberg, 2007). However, as empirical evidence is mixed, it has been suggested that moderating factors may influence the relationship between CVC and depressive symptoms (e.g., El-Sheikh et al, 2007; Yang et al, 2011). …”

Section: Discussionmentioning

confidence: 99%

“…Studies investigating the link between CVC and depressive symptoms have just started to take sleep quality into account, mainly in clinical samples (Bylsma, Salomon, Taylor-Clift, Morris, & Rottenberg, 2014; Yang et al, 2011). These studies support the idea that sleep may play a role in the link between CVC and depressive symptoms by showing, for example, links between reduced sleep quality and reduced CVC in depressed but not in healthy individuals (Yang et al, 2011).…”

Section: Sleep As a Moderator Of The Link Between Cvc And Depressive mentioning

confidence: 99%

See 2 more Smart Citations

Cardiac Vagal Control and Depressive Symptoms: The Moderating Role of Sleep Quality

Werner

Ford

Mauss

et al. 2016

Behavioral Sleep Medicine

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Lower cardiac vagal control (CVC) has been linked to greater depression. However, this link has not been consistently demonstrated, suggesting the presence of key moderators. Sleep plausibly is one such factor. Therefore, we investigated whether sleep quality moderates the link between CVC (quantified by high-frequency heart rate variability, HF-HRV) and depressive symptoms (assessed using established questionnaires) in 29 healthy women. Results revealed a significant interaction between HF-HRV and sleep quality in predicting depressive symptoms: participants with lower HF-HRV reported elevated depressive symptoms only when sleep quality was also low. In contrast, HF-HRV was not associated with depressive symptoms when sleep quality was high, suggesting a protective function of high sleep quality in the context of lower CVC.

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Section: Sleep As a Moderator Of The Link Between Cvc And Depressive supporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Sleep As a Moderator Of The Link Between Cvc And Depressive mentioning

confidence: 99%

See 1 more Smart Citation

Cardiac Vagal Control and Depressive Symptoms: The Moderating Role of Sleep Quality

Werner

Ford

Mauss

et al. 2016

Behavioral Sleep Medicine

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“…Effect sizes for polysomnographically determined sleep were taken from the same meta-analysis [25•]. With respect to physiological variables, standardized mean effect sizes were calculated for NREM EEG beta activity [22,[26][27][28][29][30][31][32][33] and resting heart rate [34][35][36][37][38][39][40] as the two most frequently investigated putative physiological indicators of hyperarousal in insomnia. Effect sizes for daytime cognitive performance were taken from the meta-analysis of Fortier-Brochu et al [5].…”

Section: The Promise Of Neuroimagingmentioning

confidence: 99%

Neuroimaging Insights into Insomnia

Spiegelhalder

Regen

Baglioni

et al. 2015

Curr Neurol Neurosci Rep

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Insomnia is one of the most prevalent health complaints afflicting approximately 10% of the population in Western industrialized countries at a clinical level. Despite the proposition that both biological and psychological factors play a role in the experience of insomnia, the field continues to puzzle over so-called "discrepancies" between objective and subjective measurements of sleep and daytime functioning. The promise of neuroimaging is to uncover physiological processes that may readily explain patient reports. However, while there has been an explosion in the number of studies investigating the neural correlates of insomnia with neuroimaging technologies, there appears to be little consistency in findings across studies. We suggest a number of methodological reasons which may, at least partially, explain variability in findings across neuroimaging studies in insomnia.

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“…In line with results of our study, emerging evidence indicates that reductions in parasympathetic tone are also present during waking hours. Subjective sleep quality parameters, including the time it takes to fall asleep at night, have been associated with reduced parasympathetic tone during wake in clinical populations (Hovland et al, 2013;Yang et al, 2011), and in healthy young women without sleep disorders (Werner et al, 2015). During waking hours, adequate parasympathetic control of the heart may serve to accelerate inhibitory, de-arousal processes necessary for falling asleep at night, while reduced parasympathetic tone may impair these processes (Werner et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Insomnia symptoms and heart rate recovery among patients in cardiac rehabilitation

et al. 2016

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Insomnia symptoms (i.e., difficulty falling asleep, difficulty staying asleep, and early morning awakenings) are common among people with cardiovascular disease, and have been linked to adverse cardiovascular health outcomes. Reduced parasympathetic tone is one pathway through which risk may be conferred. The purpose of this study was to evaluate whether insomnia symptoms are associated with lower parasympathetic tone in cardiac rehabilitation patients with suspected insomnia. Participants (N = 121) completed a self-report measure of insomnia severity. 1-min heart rate recovery (HRR), an index of parasympathetic tone, was obtained during a maximal exercise test. Difficulty falling asleep, but not difficulty staying asleep or early awakenings, was associated with attenuated 1-min HRR. When analyses were restricted to participants with moderate and severe insomnia severity (n = 51), the strength of this association increased. In a sample of cardiac rehabilitation patients with insomnia, only the symptom of difficulty falling asleep was associated with lower parasympathetic tone, suggesting that individual insomnia symptoms may show specificity in their associations with physiological mechanisms.

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Reduced physiologic complexity is associated with poor sleep in patients with major depression and primary insomnia

Cited by 101 publications

References 38 publications

Cardiac Vagal Control and Depressive Symptoms: The Moderating Role of Sleep Quality

Cardiac Vagal Control and Depressive Symptoms: The Moderating Role of Sleep Quality

Neuroimaging Insights into Insomnia

Insomnia symptoms and heart rate recovery among patients in cardiac rehabilitation

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