Reduced Recovery of Translocations from X-Irradiated Spermatogonial Stem Cells of Dominant Spotting (W v /+) and Steel (Sl con /Sl con ) Mice

To characterize further the radiosensitivity of severe combined immunodeficiency (scid) mice, the induction of micronuclei (MN) in polychromatic erythrocytes as well as cell killing and translocation induction in stem cell spermatogonia was studied. Scid mice turned out to be clearly hypersensitive for X-ray-induced cell killing of both bonemarrow cells and spermatogonial stem cells. The frequencies of recorded micronuclei in polychromatic erythrocytes were comparable with that reported for the normal mouse, whereas the recovery of translocations was extremely low in the scid mouse. The dose-response relationship for induced translocations was bell shaped with a maximum of about 0.5% around doses of 0.5-1.5 Gy X-rays.

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Reduced Recovery of Translocations from X-Irradiated Spermatogonial Stem Cells of Dominant Spotting (W v /+) and Steel (Sl con /Sl con ) Mice

Cited by 3 publications

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The induction of chromosomal damage and cell killing in mouse spermatogonial stem cells following combined treatments with hydroxyurea, 3-aminobenzamide and X-rays

The induction of chromosomal damage and cell killing in mouse spermatogonial stem cells following combined treatments with hydroxyurea, 3-aminobenzamide and X-rays

Enhanced recovery of radiation-induced translocations from spermatogonial stem cells of p53 null mice

X-ray-induced Chromosomal Aberrations and Cell Killing in Somatic and Germ Cells of theScidMouse

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