Reduced relative dose intensity of primary chemotherapy does not influence prognosis of patients with Hodgkin lymphoma

Abstract

Aims.A retrospective analysis of patients with Hodgkin lymphoma (HL) was performed to assess their outcome regarding relative dose intensity (RDI) of chemotherapy administered in primary treatment. Methods. A total of 194 patients were divided into three groups with different RDI of primary chemotherapy (100%, 90-99% and < 90%). Reduced RDI in two groups (90-99% and < 90%) was caused by the delay of the interval between the administration of some chemotherapeutic courses. The probability of complete remission (CR), disease relapse, eventfree survival (EFS) and overall survival (OS) as the basic parameters of patient outcome were statistically compared. Results. Multivariate analysis showed here were no significant differences in probability of CR (HR 0.9

Treatment outcomes and relative dose intensity of chemotherapy in patients with advanced Hodgkin lymphoma

“…Similar conclusions were also drawn by Raida et al ( 28 ). Likewise, they found no influence of primary chemotherapy DI on the probability of complete remission, disease relapse, event-free survival and OS.…”

“…Therefore, the calculation of RDI for all 8 cycles of ABVD, the older age of patients and the advanced stage HL in all patients might explain the difference in lower RDI achieved in our study. Similar conclusions were also drawn by Raida et al (28). Likewise, they found no influence of primary chemotherapy DI on the probability of complete remission, disease relapse, event-free survival and OS.…”

Treatment Outcomes and Relative Dose Intensity of Chemotherapy in Slovene Patients With Advanced Hodgkin Lymphoma

“…Similar conclusions were also drawn by Raida and colleagues [30]. Likewise, they found no in uence of primary chemotherapy DI on the probability of complete remission, disease relapse, event-free survival and OS.…”