Reduced right ventricular ejection fraction as a marker for idiopathic dilated cardiomyopathy compared with ischemic left ventricular dysfunction

Vecchia, Luigi La; Zanolla, Luisa; Varotto, L; Bonanno, Carlo; Spadaro, Gian Luca; Ometto, R; Fontanelli, A

doi:10.1067/mhj.2001.116071

Cited by 96 publications

(70 citation statements)

References 30 publications

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“…19 The early diastolic velocity is also reduced in patients with CHF compared with healthy controls for both mitral and tricuspid annuli. 17 Although previous studies have shown that DCM is characterized by more severe RV systolic dysfunction than ICM, [20][21][22] to our knowledge there is no study in the literature comparing the RV diastolic function of the 2 entities. Furthermore, the discrepancy between our results and those of previous studies concerning RV systolic involvement may be multifactorial.…”

Section: Discussionmentioning

confidence: 68%

“…Only a weak inverse relationship was found for patients with DCM, whereas in ICM this relationship was much stronger given the same level of LV dysfunction. 20 This may indicate that the development of pulmonary hypertension is a sign of advanced disease resulting in RV dysfunction in ICM. In contrast, RV dysfunction observed in DCM may be the result of the myopathic process affecting the myocardium of both ventricles, rather than of pulmonary hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…The fact that in the study by La Vecchia et al only 74% of ICM patients had a history of previous MI and 84% had 3-vessel disease, whereas in the present study these percentages were 93% and 95%, respectively, may partially explain the discrepancy between the results. 20 Juillière et al recruited a smaller sample of patients and matched the 2 groups for mean pulmonary artery pressure. 21 Finally, in the retrospective study by Iskandrian et al, in which gated radionuclide angiography was used for RV performance evaluation, patients with DCM were older and did nor receive -blockers, whereas patients with ICM had a lower incidence of a documented previous MI (49%) and prevalence of 3-vessel disease (59%).…”

Section: Discussionmentioning

confidence: 99%

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Right Ventricular Function in Ischemic or Idiopathic Dilated Cardiomyopathy

Parcharidou

Giannakoulas

Efthimiadis

et al. 2008

Circ J

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hronic heart failure (CHF) has emerged as the most prevalent cause of mortality, morbidity and hospitalization in industrialized countries over the past years. 1 Despite the advances in medical and invasive treatment of CHF, its incidence is expected to rise in the future because of improved survival rates following acute myocardial infarction (MI), which is the principal etiology of CHF in >70% of patients. 2 Traditionally, great emphasis was put on evaluation of the various etiologic factors of this syndrome. Differentiation between ischemic cardiomyopathy (ICM) and idiopathic dilated cardiomyopathy (DCM) has important therapeutic implications because the former may gain substantial benefit from coronary revascularization. 3 Conventional echocardiography is commonly used for the evaluation of left ventricular (LV) and right ventricular (RV) function, but does not provide detailed information about myocardial systolic and diastolic properties in the regional segments. Tissue Doppler echocardiography (TDE) is a promising ultrasonographic technique that quantitatively measures the velocity of the myocardium in systole and diastole. 4 Traditionally, the principal target of the cardiologist is the evaluation of the LV function, with little interest in the RV. In spite of the fact that several recent studies have used the TDE technique in the assessment of RV function in various clinical conditions, 5,6 the literature on the RV and its impact on the pathophysiologic processes is limited. However, there is a growing body of evidence that RV function is a powerful predictor of mortality in patients with CHF. 7 We hypothesized that ICM and DCM differ in terms of RV function. Thus, the aim of our study was to investigate the RV function in patients with ICM and DCM using pulsed wave TDE and to compare the TDE parameters of the RV among the patients with ischemic and idiopathic dilated causes of LV dysfunction. Methods Study PopulationWe prospectively studied 82 consecutive patients with CHF who had undergone an echocardiographic examination at the AHEPA Hospital (Thessaloniki, Greece). CHF was defined as the presence of heart failure symptoms plus a dilated (>55 mm in end-diastolic diameter) LV with a depressed (<40%) ejection fraction of uncertain origin. The inclusion criteria were: (a) good quality echocardiographic imaging of tricuspid and mitral annular motion, (b) adequate tricuspid valve regurgitation Doppler signal in order to assess pulmonary artery systolic pressure, (c) sinus rhythm on electrocardiography (ECG), and (d) stable clinical condition. The following were considered as exclusion criteria:

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Right Ventricular Function in Ischemic or Idiopathic Dilated Cardiomyopathy

Parcharidou

Giannakoulas

Efthimiadis

et al. 2008

Circ J

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“…In our study, we found that RVEF is related to quality of life. We consider that functional capacity and symptoms are worse in HF patients if RVEF is affected (Kindman et al 1994;La Vecchia et al 2001. This fi nding requires confi rmation from additional studies.…”

Section: Discussionmentioning

confidence: 99%

Health Related Quality of Life in Patients Awaiting Heart Transplantation

Karapolat

Eyigör

Zoghi

et al. 2008

Tohoku J. Exp. Med.

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Quality of life is an important outcome measure in patients with end-stage heart failure waiting for heart transplantation. The purpose of this study was to investigate the relationship between aspects of quality of life and physiological and psychosocial variables in patients with end-stage heart failure. A total of 123 patients participated in the study. The functional status was assessed with New York Heart Association (NYHA) functional classifi cation, a 6-minute walk test (6 MWT) and peak oxygen uptake (pVO 2 ). Health related quality of life (HRQOL) was measured with Medical Outcomes Study, 36-item Short Form Survey (SF-36), and Minnesota Living with Heart Failure Questionnaire (MLHFQ). Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) were used to assess psychological symptoms. A signifi cant relationship was found between HRQOL (SF-36 and MLHFQ) and functional status (NYHA, 6 MWT and pVO 2 ) ( p < 0.05). Psychological symptoms (BDI) were associated with HRQOL ( p < 0.05). In addition to clinical derangements, functional limitation and psychological distress can lead to limitations in activities of daily life through impairment of quality of life. It would be helpful to evaluate psychological symptoms and quality of life in patients with end-stage heart failure besides routine clinical evaluations.health related quality of life; heart failure; functional capacity; psychological variables. Tohoku

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“…7 The prognostic role of impaired right ventricular (RV) function in DCM is increasingly recognized. Although the exact prevalence is poorly defined, RV systolic dysfunction has been reported in as many as 65% of patients 8 suggesting that DCM is frequently a biventricular disease. The prognostic impact of RV impairment has been recently highlighted in a large study using CMR which is now considered as the gold standard for RV assessment.…”

Section: Ventricular Function and Prognosis In Dcmmentioning

confidence: 99%

Positron emission tomography: An additional prognostic tool in dilated cardiomyopathy?

Neglia

2016

Journal of Nuclear Cardiology

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Reduced right ventricular ejection fraction as a marker for idiopathic dilated cardiomyopathy compared with ischemic left ventricular dysfunction

Cited by 96 publications

References 30 publications

Right Ventricular Function in Ischemic or Idiopathic Dilated Cardiomyopathy

Right Ventricular Function in Ischemic or Idiopathic Dilated Cardiomyopathy

Health Related Quality of Life in Patients Awaiting Heart Transplantation

Positron emission tomography: An additional prognostic tool in dilated cardiomyopathy?

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