Reduced salience and default mode network activity in women with anorexia nervosa

McFadden, Kristina L.; Tregellas, Jason R.; Shott, Megan E.; Frank, Guido

doi:10.1503/jpn.130046

Cited by 96 publications

(111 citation statements)

References 73 publications

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“…In line with the results of McFadden and colleagues, 24 we found that aberrant rsFC in the DMN seems to normalize with recovery and therefore constitutes a state marker of the disease. In contrast, Cowdrey and colleagues 22 reported increased rsFC in the DMN for recovered patients, but no difference in the FPN.…”

Section: Discussionsupporting

confidence: 92%

“…Cowdrey and colleagues 22 reported increased rsFC in the DMN but no differences in the FPN, the visual or somatosensory networks. In contrast, reduced rsFC in the visual network was reported by Favaro and colleagues, 23 while McFadden and colleagues 24 showed reduced rsFC strength in the salience network and sensorimotor network (the latter data were obtained during a task that may impact RSNs 25 ). Using a seedbased approach, Favaro and colleagues 26 reported that the observed alterations in rsFC of the striatal network in acutely ill patients vanished with recovery.…”

Section: Introductionmentioning

confidence: 85%

See 1 more Smart Citation

Partially restored resting-state functional connectivity in women recovered from anorexia nervosa

Boehm

Geisler

Tam

et al. 2016

jpn

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 85%

Partially restored resting-state functional connectivity in women recovered from anorexia nervosa

Boehm

Geisler

Tam

et al. 2016

jpn

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“…Our results are supported by the findings of McFadden and colleagues, 8 who reported reduced resting state activity in the ACC, in the precuneus and in several regions of the SMN in patients with anorexia nervosa. Cowdrey and colleagues 51 observed an abnormal functional connectivity in the precuneus and lateral prefrontal regions in recovered patients with anorexia nervosa.…”

Section: Stgsupporting

confidence: 92%

“…Both the anterior (ACC) and posterior cingulate cortices (PCC) have been identified to function abnormally in these individuals. 2,4,[7][8][9] The third prominent brain region supposed to play a major role in anorexia nervosa is the insula. [10][11][12] This part of the brain is involved in the processing of emotion, pain perception, interoception and cognitive functioning as well as in the regulation of bodily homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa

Bär

Cruz

Berger

et al. 2015

jpn

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“…5,41 Abnormal decreased connectivity within the default mode network is further associated with a host of conditions of memory and executive dysfunction. 24,26,31,44,47 Our similar findings of decreased and negative connectivity involving the posterior cingulate cortex, precuneus, and ventromedial prefrontal cortex in the sagittal group may explain some of the executive dysfunction, learning disabilities, and/or behavioral problems observed in the condition. It should be recalled, as a final note, that both the prefrontal and lateral parietal seeds-in conjunction with and independent of the intrinsic network analysis-negatively correlated with the precuneus and/or cingulate, supporting the idea that the major default mode network nodes have convincing abnormal connectivity in sNSC.…”

Section: Discussionmentioning

confidence: 51%

Altered brain connectivity in sagittal craniosynostosis

Beckett

Brooks

Lacadie

et al. 2014

PED

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Object Sagittal nonsyndromic craniosynostosis (sNSC) is the most common form of NSC. The condition is associated with a high prevalence (> 50%) of deficits in executive function. The authors employed diffusion tensor imaging (DTI) and functional MRI to evaluate whether hypothesized structural and functional connectivity differences underlie the observed neurocognitive morbidity of sNSC. Methods Using a 3-T Siemens Trio MRI system, the authors collected DTI and resting-state functional connectivity MRI data in 8 adolescent patients (mean age 12.3 years) with sNSC that had been previously corrected via total vault cranioplasty and 8 control children (mean age 12.3 years) without craniosynostosis. Data were analyzed using the FMRIB Software Library and BioImageSuite. Results Analyses of the DTI data revealed white matter alterations approaching statistical significance in all supratentorial lobes. Statistically significant group differences (sNSC < control group) in mean diffusivity were localized to the right supramarginal gyrus. Analysis of the resting-state seed in relation to whole-brain data revealed significant increases in negative connectivity (anticorrelations) of Brodmann area 8 to the prefrontal cortex (Montreal Neurological Institute [MNI] center of mass coordinates [x, y, z]: −6, 53, 6) and anterior cingulate cortex (MNI coordinates 6, 43, 14) in the sNSC group relative to controls. Furthermore, in the sNSC patients versus controls, the Brodmann area 7, 39, and 40 seed had decreased connectivity to left angular gyrus (MNI coordinates −31, −61, 34), posterior cingulate cortex (MNI coordinates 13, −52, 18), precuneus (MNI coordinates 10, −55, 54), left and right parahippocampus (MNI coordinates −13, −52, 2 and MNI coordinates 11, −50, 2, respectively), lingual (MNI coordinates −11, −86, −10), and fusiform gyri (MNI coordinates −30, −79, −18). Intrinsic connectivity analysis also revealed altered connectivity between central nodes in the default mode network in sNSC relative to controls; the left and right posterior cingulate cortices (MNI coordinates −5, −35, 34 and MNI coordinates 6, −42, 39, respectively) were negatively correlated to right hemisphere precuneus (MNI coordinates 6, −71, 46), while the left ventromedial prefrontal cortex (MNI coordinates 6, 34, −8) was negatively correlated to right middle frontal gyrus (MNI coordinates 40, 4, 33). All group comparisons (sNSC vs controls) were conducted at a whole brain–corrected threshold of p < 0.05. Conclusions This study demonstrates altered neocortical structural and functional connectivity in sNSC that may, in part or substantially, underlie the neuropsychological deficits commonly reported in this population. Future studies combining analysis of multimodal MRI and clinical characterization data in larger samples of participants are warranted.

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Reduced salience and default mode network activity in women with anorexia nervosa

Cited by 96 publications

References 73 publications

Partially restored resting-state functional connectivity in women recovered from anorexia nervosa

Partially restored resting-state functional connectivity in women recovered from anorexia nervosa

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa

Altered brain connectivity in sagittal craniosynostosis

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