2024
DOI: 10.1002/dvdy.707
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Reduced mTORC1‐signaling in progenitor cells leads to retinal lamination deficits

Christoffer Nord,
Iwan Jones,
Maria Garcia‐Maestre
et al.

Abstract: BackgroundNeuronal lamination is a hallmark of the mammalian central nervous system (CNS) and underlies connectivity and function. Initial formation of this tissue architecture involves the integration of various signaling pathways that regulate the differentiation and migration of neural progenitor cells.ResultsHere, we demonstrate that mTORC1 mediates critical roles during neuronal lamination using the mouse retina as a model system. Down‐regulation of mTORC1‐signaling in retinal progenitor cells by conditio… Show more

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