Reduced Sensory Habituation in Autism and Its Correlation with Behavioral Measures

Jamal, Wasifa; Cardinaux, Annie; Haskins, Amanda J.; Kjelgaard, Margaret; Sinha, Pawan

doi:10.1007/s10803-020-04780-1

Cited by 41 publications

(44 citation statements)

References 42 publications

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“…In neurotypicals, the P3 has previously been shown to habituate in response to repeated auditory, visual, and somatosensory stimuli (Nakata et al, 2015;Romero & Polich, 1996). Given the high number of trial repetitions, and reports of reduced visual habituation in autism (Jamal et al, 2020;Kleinhans et al, 2009;Vivanti et al, 2018;Webb et al, 2010), the larger P3 amplitude in the autism group might represent reduced habituation in response to the repeated visual stimulation.…”

Section: Discussionmentioning

confidence: 98%

Equivalent own name bias in autism: An EEG study of the Attentional Blink

Nijhof

Solz

Catmur

et al. 2021

Cogn Affect Behav Neurosci

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The “Attentional Blink” refers to difficulty in detecting the second of two target stimuli presented in rapid temporal succession. Studies have shown that salient target stimuli, such as one’s own name, reduce the magnitude of this effect. Given indications that self-related processing is altered in autism, it is an open question whether this attentional self-bias is reduced in autism. To investigate this, in the current study we utilised an Attentional Blink paradigm involving one’s own and others’ names, in a group of 24 autistic adults, and 22 neurotypical adults, while measuring EEG. In line with previous studies, the Attentional Blink was reduced when the participant’s own name was the second target, with no differences between autistic and neurotypical participants. ERP results show that the effect on the Attentional Blink of one’s own name was reflected in increased N2 and P3 amplitudes, for both autistic and nonautistic individuals. This is the first event-related potential study of own-name processing in the context of the Attentional Blink. The results provide evidence of an intact attentional self-bias in autism, both at the behavioural and neural level.

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Section: Discussionmentioning

confidence: 98%

Equivalent own name bias in autism: An EEG study of the Attentional Blink

Nijhof

Solz

Catmur

et al. 2021

Cogn Affect Behav Neurosci

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“…Which elements of experience might influence the emergence of ASD is not clear (Baum et al, 2015;Robertson and Baron-Cohen, 2017). However, given the mostly complex multigenic basis of ASD predisposition, the identification of environmental factors affecting individuals from a range of predisposed genetic back-grounds would have important therapeutic implications (Baron-Cohen and Belmonte, 2005;Bourgeron, 2015;Chen et al, 2020;Geschwind, 2009;Jamal et al, 2021;Sahin and Sur, 2015).…”

Section: Introductionmentioning

confidence: 99%

Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling

Krüttner

Falasconi

Valbuena

et al. 2022

Neuron

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“…In ASD cohorts, impairments in habituation have been found throughout development (e.g. [55,[242][243][244]. Reduced habituation has been observed as early as 3 or 6 months of age in infants at familial risk for ASD [245,246].…”

Section: Habituation Deficits In Diseasementioning

confidence: 99%

“…Reduced habituation has been observed as early as 3 or 6 months of age in infants at familial risk for ASD [245,246]. In children diagnosed with ASD of age 7 to 13 years, habituation deficits have been shown to correlate with several clinical scores associated with competence along diverse phenotypic dimensions, such as a social communication score and parents' questionnaire scoring the severity of sensory difficulties [244]. Reduced habituation is also widely observed in adults diagnosed with ASD (e.g.…”

Section: Habituation Deficits In Diseasementioning

confidence: 99%

“…In addition to the large amount of clinical and scientific literature supporting habituation as a disease-and cognition-relevant property, there are also reports that did not find significant anomalies in habituation in individuals diagnosed with the aforementioned disorders (e.g. in OCD [297][298][299], ADHD [300][301][302][303], schizophrenia [304], and HD [305,306]), or found no correlation between habituation and measures of IQ [244]. We noticed that most of these studies used an experimental design that was not optimized to assess habituation, but e.g.…”

Section: Habituation and Cognitionmentioning

confidence: 99%

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Genetics, Molecular Control and Clinical Relevance of Habituation Learning

Blok¹,

Boon²,

Reijmersdal³

et al. 2022

Preprint

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Habituation, the most ancient and fundamental form of learning, manifests already before birth. Neuroscientists have been fascinated for decades by its function as a firewall protecting our brains from sensory information overload and its indispensability for higher cognitive processing. Evidence that habituation learning is affected in autism and related monogenic neurodevelopmental syndromes and their animal models has exponentially grown, but the potential of this convergence to advance both fields is still largely unexploited.In this review, we provide a systematic overview of the genes that to date have been demonstrated to underlie habituation across species. We describe the biological processes they converge on, and highlight core regulatory pathways and repurposable drugs that may alleviate the habituation deficits associated with their dysregulation. We also summarize currently used habituation paradigms and extract the most important arguments from literature that support the crucial role of habituation for cognition in health and disease. We conclude that habituation is a powerful tool to overcome current bottlenecks in research, diagnostics and treatment of neurodevelopmental disorders.

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Reduced Sensory Habituation in Autism and Its Correlation with Behavioral Measures

Cited by 41 publications

References 42 publications

Equivalent own name bias in autism: An EEG study of the Attentional Blink

Equivalent own name bias in autism: An EEG study of the Attentional Blink

Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling

Genetics, Molecular Control and Clinical Relevance of Habituation Learning

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