Reduced serum club cell protein as a pulmonary damage marker for chronic fine particulate matter exposure in Chinese population

Wang, Yanhua; Duan, Huawei; Meng, Tao; Shen, Mengyan; Ji, Qianpeng; Xing, Jie; Wang, Qingrong; Wang, Ting; Niu, Yong; Yu, Tao; Liu, Zhong; Jia, Hongbing; Zhan, Yuliang; Chen, Wen; Zhang, Zhihu; Su, Wenge; Dai, Yufei; Zhang, Xuchun; Zheng, Yuxin

doi:10.1016/j.envint.2017.12.024

Cited by 20 publications

(7 citation statements)

References 56 publications

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“…In the placebo group, a significant negative association between PM 2.5 exposure and the levels with serum CC16. Our findings was consistent with a previous study which found that serum CC16 levels decreased in a dose response manner in association with both external and internal PM 2.5 exposures in a two cohorts (Wang et al, 2018). However, some research studies showed that acute exposure to PM could induce an immediate increase in blood CC16 levels (Guarnieri et al, 2007; Wang et al, 2017), which may stem from elevated secretion in the respiratory tract and increased leakage through the bronchoalveolar–blood barrier.…”

Section: Discussionsupporting

confidence: 93%

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM₂_.5 in air pollution‐induced cardiopulmonary damage among adults

Qiu

Chen²,

Wang

et al. 2020

Phytotherapy Research

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Exposure to PM2.5 (particulate matter with an aerodynamic diameter ≤ 2.5 μm) has been associated with increased cardiopulmonary outcomes, mediated by a hypothesized biological mechanism of systemic inflammation and oxidation. This randomized, double‐blinded and placebo‐controlled trial among 120 healthy adults in Wuhan, China, was conducted to evaluate whether the supplementation of herbal product composed of Ginseng, Lilii Bulbus and Poria (GLP) which have been shown to have anti‐inflammatory and anti‐oxidant activity offers protective effects on PM2.5‐induced damage to cardiopulmonary health. Participants received four rounds of health examinations and two rounds of blood sample collection from November 2018 to January 2019. Compared to the placebo group, the GLP group showed significant increased antioxidant biomarkers such as superoxide dismutase (SOD) and paraoxonase1 (PON1). What is more, interleukin‐6 (IL‐6), an inflammatory biomarker, was significantly decreased in the GLP group. In addition, nitric oxide and club cell secretory protein (CC16) were increased but heart rate was decreased in the GLP group. As for pulmonary function indicators, significantly increased fractional exhaled nitric oxide (FeNO) was observed in the GLP group. Taken together, we concluded that GLP supplementation is associated with decreased inflammatory biomarker and increased antioxidant biomarkers suggesting cardiopulmonary benefits against PM2.5 exposure among young adults in China.

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Section: Discussionsupporting

confidence: 93%

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM₂_.5 in air pollution‐induced cardiopulmonary damage among adults

Qiu

Chen²,

Wang

et al. 2020

Phytotherapy Research

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“…However, the difference of sex, smoking, and alcohol drinking (all P < 0.001) were significant between groups. 23 Compared to the controls, the concentrations of individual PAHs, urinary PAH metabolites, and most metals in exposed groups were increased significantly (P < 0.05). 8,27 We detected the Tlymphocyte subsets in venous blood.…”

Section: Subject Characteristics and T-lymphocytementioning

confidence: 87%

“…We have reported the characteristics of the study participants and exposure levels (Table S1). 8,23,27 Briefly, age, recent infection status, and BMI were not different between control and exposed population. However, the difference of sex, smoking, and alcohol drinking (all P < 0.001) were significant between groups.…”

Section: Subject Characteristics and T-lymphocytementioning

confidence: 99%

“…27 The participants' selection criteria, exclusion criteria, general characteristics, definitions of smokers and drinkers, and exposure classification had been described previously. 23 More details are provided in the Supporting Information. All subjects gave their written informed consent.…”

Section: Population Characteristic and Biological Samplementioning

confidence: 99%

“…21,22 There is wide experimental evidence that pulmonary inflammation and immune disorders caused by PM may be an important potential toxic effects. 15,23,24 Shen et al demonstrated that PM 2.5 exposure caused Th1/Th2 imbalance and increase inflammatory cell infiltrating in the airways of healthy rats. 15 Furthermore, it has been shown that PAHs can give rise to immune impairments through mediating epigenetic changes in Treg lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

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Particulate Matter and Its Components Induce Alteration on the T-Cell Response: A Population Biomarker Study

Meng

Wang

et al. 2022

Environ. Sci. Technol.

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Compared with the T-cell potential of particulate matter (PM) in animal studies, comprehensive evaluation on the impairments of T-cell response and exposure−response from PM and its components in human population is limited. There were 768 participants in this study. We measured environmental PM and its polycyclic aromatic hydrocarbons (PAHs) and metals and urinary metabolite levels of PAHs and metals among population. T lymphocyte and its subpopulation (CD4 + T cells and CD8 + T cells) and the expressions of T-bet, GATA3, RORγt, and FoxP3 were measured. We explored the exposure−response of PM compositions by principal component analysis and mode of action by mediation analysis. There was a significant decreasing trend for T lymphocytes and the levels of T-bet and GATA3 with increased PM levels. Generally, there was a negative correlation between PM, urinary 1-hydroxypyrene, urinary metals, and the levels of T-bet and GATA3 expression. Additionally, CD4 + T lymphocytes were found to mediate the associations of PM 2.5 with T-bet expression. PM and its bound PAHs and metals could induce immune impairments by altering the T lymphocytes and genes of T-bet and GATA3.

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Inflammation biomarkers associated with arsenic exposure by drinking water and respiratory outcomes in indigenous children from three Yaqui villages in southern Sonora, México

Vega-Millán

Dévora-Figueroa

Burgess

et al. 2021

Environ Sci Pollut Res

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Environmental arsenic exposure in adults and children has been associated with a reduction in the expression of club cell secretory protein (CC16) and an increase in the expression of matrix metalloproteinase-9 (MMP-9), both biomarkers of lung inflammation and negative respiratory outcomes. The objectives of this study were to determine if the levels of serum CC16 and MMP-9 and subsequent respiratory infections in children are associated with the ingestion of arsenic by drinking water. This cross-sectional study included 216 children from three Yaqui villages, Potam, Vicam, and Cocorit, with levels of arsenic in their ground water of 70.01 ± 21.85, 23.3 ± 9.99, and 11.8 ± 4.42 μg/L respectively. Total arsenic in water and urine samples was determined by inductively coupled plasma/optical emission spectrometry. Serum was analyzed for CC16 and MMP-9 using ELISA. The children had an average urinary arsenic of 79.39 μg/L and 46.8 % had levels above of the national concern value of 50 μg/L. Increased arsenic concentrations in drinking water and average daily arsenic intake by water were associated with decreased serum CC16 levels (β = − 0.12, 95% CI − 0.20, − 0.04 and β = − 0.10, 95% CI − 0.18, − 0.03), and increased serum MMP-9 levels (β = 0.35, 95% CI 0.22, 0.48 and β = 0.29, 95% CI 0.18, 0.40) at significant levels ( P < 0.05). However, no association was found between levels of these serum biomarkers and urinary arsenic concentrations. In these children, reduced serum CC16 levels were significantly associated with increased risk of respiratory infections (OR = 0.34, 95% CI 0.13, 0.90). In conclusion, altered levels of serum CC16 and MMP-9 in the children may be due to the toxic effects of arsenic exposure through drinking water. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-021-13070-x.

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Reduced serum club cell protein as a pulmonary damage marker for chronic fine particulate matter exposure in Chinese population

Cited by 20 publications

References 56 publications

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM₂_.5 in air pollution‐induced cardiopulmonary damage among adults

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM₂_.5 in air pollution‐induced cardiopulmonary damage among adults

Particulate Matter and Its Components Induce Alteration on the T-Cell Response: A Population Biomarker Study

Inflammation biomarkers associated with arsenic exposure by drinking water and respiratory outcomes in indigenous children from three Yaqui villages in southern Sonora, México

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Reduced serum club cell protein as a pulmonary damage marker for chronic fine particulate matter exposure in Chinese population

Cited by 20 publications

References 56 publications

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM2.5 in air pollution‐induced cardiopulmonary damage among adults

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM2.5 in air pollution‐induced cardiopulmonary damage among adults

Particulate Matter and Its Components Induce Alteration on the T-Cell Response: A Population Biomarker Study

Inflammation biomarkers associated with arsenic exposure by drinking water and respiratory outcomes in indigenous children from three Yaqui villages in southern Sonora, México

Contact Info

Product

Resources

About

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM₂_.5 in air pollution‐induced cardiopulmonary damage among adults

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM₂_.5 in air pollution‐induced cardiopulmonary damage among adults