Reduced serum corin levels in patients with osteoporosis

Zhou, Haibin; Liu, Wei; Zhu, Jinsong; Li, Meng; Fang, Chaodong; Wu, Qingyu; Dong, Ningzheng

doi:10.1016/j.cca.2013.09.007

Cited by 18 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It will be particularly important to examine the structure and morphology of cartilage tissues that are made of mostly chondrocytes. Previously, we also found reduced serum corin levels in patients with osteoporosis, which correlated with high rates of bone turnover (Zhou et al, ). These findings should encourage more studies to understand the role of corin in bone/cartilage development and homeostasis.…”

Section: Discussionsupporting

confidence: 62%

Role of the protease corin in chondrogenic differentiation of human bone marrow‐derived mesenchymal stem cells

Zhou

Zhu

Meng

et al. 2017

J Tissue Eng Regen Med

Self Cite

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) have the potency to differentiate into chondrocytes, osteocytes and adipocytes. Corin is a cardiac protease that activates the natriuretic peptides, thereby regulating blood volume and pressure. In addition to the heart, corin gene upregulation was reported in bone marrow- and adipose tissue-derived MSCs that underwent osteogenic differentiation. To date, the biological significance of corin expression in MSC differentiation remains unknown. In this study we isolated and cultured human bone marrow-derived MSCs that were capable of undergoing chondrogenic, osteogenic and adipogenic lineage differentiation. By reverse transcription polymerase chain reaction (RT-PCR) and immunostaining, we found that corin expression was upregulated when these MSCs underwent chondrogenic, osteogenic and adipogenic differentiation. The upregulation of corin expression was most significant in the cells undergoing chondrogenic lineage differentiation. Silencing corin gene expression by small hairpin RNA in the MSCs inhibited chondrogenic, but not osteogenic and adipogenic, differentiation. These results suggest a novel function of corin in MSC differentiation and chondrocyte development.

show abstract

Section: Discussionsupporting

confidence: 62%

Role of the protease corin in chondrogenic differentiation of human bone marrow‐derived mesenchymal stem cells

Zhou

Zhu

Meng

et al. 2017

J Tissue Eng Regen Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…The range of serum soluble corin detected in nonhypertensive and nonobese individuals (373.39–2634.35 pg/mL) in our study was similar to that previously reported in healthy individuals (296–2590 pg/mL) . Recently, some small sample case‐control studies have examined circulating soluble corin in some disease states, such as heart failure , acute coronary syndrome , osteoporosis , and pregnant hypertension . Corin concentration in the circulation was decreased in heart failure, acute coronary syndrome, and osteoporosis but increased in pregnant hypertension.…”

Section: Discussionsupporting

confidence: 88%

Association between serum soluble corin and obesity in Chinese adults: A cross‐sectional study

Peng

Zhang

Shen

et al. 2015

Obesity

View full text Add to dashboard Cite

Objective: Corin has been suggested to be associated with obesity by cell-and animal-based studies. However, the association has not yet been studied in populations. Here, the aim was to explore the association in a general population of China. Methods: This was a cross-sectional study. Data on demographic information, lifestyle risk factors, and personal medical history were collected; body mass index, waist circumference, and blood pressures were measured; and serum corin, blood lipids, and blood glucose were determined in 2498 participants aged above 30 years. Results: Log-transformed corin correlated to body mass index (r 5 0.197, P < 0.001) and waist circumference (r 5 0.289, P < 0.001). In the risk factor-adjusted analysis, compared with participants in the lowest quartile of serum corin, participants in the 4th quartile had significantly increased risk of prevalent overweight or obesity (OR 5 2.26, 95% CI: 1.67-3.04) and central obesity (OR 5 1.74, 95% CI: 1.30-2.34). ORs of overweight or obesity and central obesity positively and significantly increased with serum corin levels (P for trend < 0.001). Conclusions: Serum soluble corin was significantly and positively associated with obesity. Our findings suggested that serum soluble corin may be a marker or risk factor for obesity.

show abstract

“…The range of serum corin (373.4-2833.3 pg/mL) detected in nonhypertensive individuals in our controls was similar to that (296-2590 pg/mL) in the previous report. 13 Recently, some small sampled case-control studies have examined circulating soluble corin in some disease states, such as heart failure, 8 acute coronary syndrome, 9 osteoporosis, 17 and pregnant hypertension. 18 Corin concentration in the circulation was decreased in heart failure 8 and acute coronary syndrome.…”

Section: Discussionmentioning

confidence: 99%

Serum Soluble Corin Is Decreased in Stroke

Peng

Zhu

Shi

et al. 2015

Stroke

View full text Add to dashboard Cite

Background and Purpose-Soluble corin was decreased in coronary heart disease. Given the connections between cardiac dysfunction and stroke, circulating corin might be a candidate marker of stroke risk. However, the association between circulating corin and stroke has not yet been studied in humans. Here, we aimed to examine the association in patients wtith stroke and community-based healthy controls. Methods-Four hundred eighty-one patients with ischemic stroke, 116 patients with hemorrhagic stroke, and 2498 healthy controls were studied. Serum soluble corin and some conventional risk factors of stroke were examined. Because circulating corin was reported to be varied between men and women, the association between serum soluble corin and stroke was evaluated in men and women, respectively. Results-Patients

show abstract

Reduced serum corin levels in patients with osteoporosis

Cited by 18 publications

References 48 publications

Role of the protease corin in chondrogenic differentiation of human bone marrow‐derived mesenchymal stem cells

Role of the protease corin in chondrogenic differentiation of human bone marrow‐derived mesenchymal stem cells

Association between serum soluble corin and obesity in Chinese adults: A cross‐sectional study

Serum Soluble Corin Is Decreased in Stroke

Contact Info

Product

Resources

About