Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification

Lee, Mi Kyung; Jekal, Yoonsuk; Im, Jee Aee; Kim, Eun Sung; Lee, Seung Hwan; Park, Ji Hye; Chu, Sang Hui; Chung, Kyongmee; Lee, Hyun Chul; Oh, Eok Soo; Kim, Sang‐Hwan; Jeon, Justin Y.

doi:10.1016/j.cca.2009.12.003

Cited by 39 publications

(31 citation statements)

References 22 publications

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“…This suggests that insulin resistance may be related to serum vaspin. It has been reported that serum vaspin was correlated negatively with HOMA-IR in diabetic patients [8] and obese children [14]. Thus, our results, together with previous observations, indicate that patients with a longer diabetic history are prone to having lower levels of vaspin.…”

Section: Discussionsupporting

confidence: 85%

Vaspin in newly and previously diagnosed Chinese type 2 diabetic females: a case-control study

et al. 2011

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Background: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipocytokine. Several studies have indicated that vaspin may exert an important role in the development of metabolic disorders. Objective: Evaluate serum vaspin and its relation to clinical parameters in newly and previously diagnosed Chinese type 2 diabetes mellitus (T2DM) females as a case-control study. Materials and methods: One hundred twenty female participants (newly and previously diagnosed T2DM patients) were recruited from an affiliated hospital of Harbin Medical University. Sixty healthy female volunteers from various communities were included as controls. Anthropometric parameters, serum fasting blood glucose, fasting insulin, lipid profile, HbA1c, and vaspin were measured in each participant. Results: Serum vaspin levels were significantly lower in previously diagnosed T2DM patients (0.51±0.29 ng/mL) than in newly diagnosed T2DM patients (0.62±0.28 ng/mL) and healthy controls (0.69±0.31 ng/mL). However, there was no difference in serum vaspin between newly diagnosed T2DM patients and healthy controls. In multiple linear regression analysis, serum vaspin was significantly and positively associated with HbA1c in both newly and previously diagnosed T2DM patients, negatively associated with homeostasis model assessment of insulin resistance in previously diagnosed patients, and positively correlated with age and body mass index in healthy controls. Conclusion: Serum vaspin was significantly lower in previously diagnosed T2DM patients than in newly diagnosed T2DM patients and healthy controls. Serum vaspin might be a predictor of poor glucose control and insulin resistance in T2DM.

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Section: Discussionsupporting

confidence: 85%

Vaspin in newly and previously diagnosed Chinese type 2 diabetic females: a case-control study

et al. 2011

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“…Two recent studies report higher vaspin levels in obese children 19 and a decrease after a short-term lifestyle modification program. 20 However, these studies have conflicting results regarding the correlation of vaspin levels with insulin or HOMA index, with both negative 20 and positive 19 correlations being reported. Moreover, it was recently observed that these variables are unrelated to vaspin levels in nondiabetic humans, 12 whereas changes are observed in those patients showing a more severe impairment of carbohydrate metabolism.…”

Section: Visfatin and Vaspin In Young Obese Children Gá Martos-morenomentioning

confidence: 99%

“…11 However, there are contrasting reports regarding the relationship between vaspin levels, body mass index (BMI) and carbohydrate metabolism impairment, 12,13 as well as regarding the influence exerted by physical training and weight reduction on its circulating levels. 14,15 To date, the studies analyzing visfatin [16][17][18] and vaspin levels 19,20 in children and adolescents are sparse and, to our knowledge, nonexistent in young prepubertal children. Moreover, the lack of pharmacological treatments for obesity in this age range poses great difficulties in the achievement of large weight reduction based exclusively upon conservative treatment.…”

Section: Introductionmentioning

confidence: 99%

Serum visfatin and vaspin levels in prepubertal children: effect of obesity and weight loss after behavior modifications on their secretion and relationship with glucose metabolism

et al. 2011

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Objective: To investigate the impact of obesity, weight loss and oral glucose ingestion on serum visfatin and vaspin levels in prepubertal children. Subjects and methods: A total of 100 prepubertal obese Caucasian children (OB) and 42 controls (C) were studied. The OB group was studied at baseline and after moderate (n ¼ 46) and extensive (n ¼ 14) body mass index (BMI) reduction by conservative treatment, undergoing body composition studies (dual-energy X-ray absorptiometry) and oral glucose tolerance tests (OGTTs). Serum visfatin and vaspin levels were studied throughout the OGTT, as were their relationships with insulin, leptin, leptin soluble receptor (sOB-R), adiponectin (total and high molecular weight), resistin, interleukin-6 (IL-6) and tumor necrosis factor-a levels at every time point. Results: OB had higher visfatin (Po0.001), but similar vaspin than C. BMI reduction decreased visfatin levels (Po0.001), with BMI, waist circumference and the surrogate markers of body fat (leptin and sOB-R) showing significant correlations (Po0.05) with this peptide, but not with vaspin. Visfatin and vaspin decreased during the OGTT (Po0.001). Weight reduction did not alter visfatin dynamics in the OGTT, but decreased the area under the curve (AUC) for vaspin (Po0.001), with a correlation between the AUCs for vaspin and insulin after weight loss (Po0.05). Visfatin levels were positively correlated with resistin and IL-6, after controlling for BMI and HOMA (homeostatic model assessment) index at every time point in the study. Conclusion: Serum visfatin, but not vaspin, levels are influenced by body fat content in obese children, whereas both adipokines are modulated by glucose intake in a BMI-dependent manner.

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“…Higher vaspin and lower adiponectin levels have been reported in obese humans (9,10); physical training (9,11) and weight loss (12) are associated with a reduction of circulating vaspin, insulin, and IR, evaluated by homeostasis model of assessment-IR (HOMA-IR). In type 2 diabetic subjects, both higher (13,14) and similar vaspin levels (8, 9, 15) compared with controls have been reported.…”

Section: Introductionmentioning

confidence: 99%

Serum vaspin levels in normal pregnancy in comparison with non-pregnant women

Giomisi

Kourtis

Toulis

et al. 2011

European Journal of Endocrinology

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Objective: Pregnancy represents a state of insulin resistance (IR). Vaspin (SERPINA12) is a novel insulin-sensitizing adipokine that might be implicated in endogenous glucose regulation. However, its role in pregnancy and its circulating levels have not been adequately studied. We aimed to evaluate serum vaspin levels in pregnancy and their correlation with known markers of IR. Design: A group of 106 women (age 27.9G0.4 years) at the 24-30th week of gestation (pregnancy group) and another 106 age-matched healthy non-pregnant controls (control group) were included in the study. Methods: Serum glucose, insulin, vaspin, adiponectin, and lipid parameters were measured. The quantitative insulin sensitivity check index (QUICKI) was used as an insulin sensitivity index. Results: Pregnant women had significantly higher body mass index (BMI), lipids, and serum insulin and lower serum glucose and vaspin levels than controls. Vaspin was positively correlated to adiponectin in both groups (P!0.001 and P!0.004 respectively) but was not correlated to BMI, serum insulin levels, or the QUICKI index in either group. Furthermore, vaspin was negatively correlated to lipid parameters (total cholesterol, triglycerides, and low-density lipoproteins) in the pregnant but not in the non-pregnant women. Conclusions: Vaspin cannot serve as a marker of IR in either pregnant or non-pregnant women, although it is significantly correlated with adiponectin. On the other hand, vaspin might be useful as a surrogate marker of lipid metabolism in pregnancy if confirmed by subsequent studies.

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Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification

Cited by 39 publications

References 22 publications

Vaspin in newly and previously diagnosed Chinese type 2 diabetic females: a case-control study

Vaspin in newly and previously diagnosed Chinese type 2 diabetic females: a case-control study

Serum visfatin and vaspin levels in prepubertal children: effect of obesity and weight loss after behavior modifications on their secretion and relationship with glucose metabolism

Serum vaspin levels in normal pregnancy in comparison with non-pregnant women

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