Reduced Skin Hyperemia During Tap Water Iontophoresis After Intake of Acetylsalicylic Acid1

Berliner, M.

doi:10.1097/00002060-199711000-00010

Cited by 22 publications

(20 citation statements)

References 12 publications

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“…Further studies should be performed to confirm whether or not sensitization exists and may directly result from anodal current application as suspected from our results. In view of the absence of sensitivity to aspirin pretreatment found in previous experiments [14, 27], it is possible that some protocols of electrical application may stimulate a prostaglandin-dependent mechanism whereas others do not. This point could be of major importance in iontophoretic microvascular studies.…”

Section: Discussionmentioning

confidence: 90%

“…Aspirin inhibition of cathodal vasodilation has been previously described [27]but previous studies failed to show any significant decrease of anodal current-induced vasodilation following aspirin pretreatment [14, 27]. The major effect of aspirin is the inhibition of prostaglandin synthesis [52, 53], but other mechanisms have been proposed [54, 55, 56], including a direct blockade of vanilloid receptors involved in nociception [57].…”

Section: Discussionmentioning

confidence: 99%

“…Prolonged continuous current applications, as frequently performed in iontophoresis, do not necessarily involve the same vasodilator mechanisms as pulsed currents do. Berliner [27], for example, demonstrated that the major vasodilation resulting from short cathodal current application, but not the limited vasodilation observed following comparable anodal current application, is attenuated following aspirin. The question remains whether, when anodal and cathodal vasodilation reach comparable amplitudes, this difference in aspirin sensitivity is still present.…”

Section: Introductionmentioning

confidence: 99%

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Current-Induced Vasodilation during Water Iontophoresis (5 min, 0.10 mA) Is Delayed from Current Onset and Involves Aspirin Sensitive Mechanisms

et al. 2002

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Study of the microcirculation by iontophoresis is potentially confounded by any non-specific effects of current application. Laser Doppler flow (LDF, mean ± SD; arbitrary units; AU) was recorded on the forearms of healthy volunteers during and 20 min following application of 0.10-mA current for 1, 3 and 5 min, using deionised water as a vehicle. Local heating to 44°C was then applied for 24 min to assess maximal vasodilation. Cathodal current applications resulted in delayed and prolonged vasodilation (peak values: 78 ± 29, 75 ± 19, 80 ± 37 AU) whereas anodal peak LDF was 13 ± 6, 27 ± 34 and 72 ± 40 AU for 1-, 3- and 5-min periods of current applications, respectively. From current onset, inflexion points in the responses to 3- and 5-min anodal current applications occurred at 4.5 and 6.5 min, respectively, and at ∼1.5 min for all cathodal current applications. For 5-min current applications: a preliminary tourniquet ischaemia neither changed the time course nor the amplitude of the response to current application. In this situation, local anaesthesia abolished the current-induced vasodilation. Chronic capsaicin pretreatment decreased the amplitude of the vasodilation. Pretreatment with 500 mg oral aspirin decreased the cathodal vasodilation and abolished the anodal vasodilation, even in the absence of preliminary ischaemia. We conclude that vasodilation to prolonged application of 0.10-mA continuous monopolar current after transient tourniquet ischaemia cannot be exclusively the result of an axon reflex initiated by current onset. This current-induced vasodilation is at least partly dependent on capsaicin-sensitive afferent fibres and relies on aspirin-sensitive mechanisms at both polarities.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Current-Induced Vasodilation during Water Iontophoresis (5 min, 0.10 mA) Is Delayed from Current Onset and Involves Aspirin Sensitive Mechanisms

et al. 2002

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“…The nonspecific response at the cathode was found stronger than the response at the anode. Since then, a number of studies have investigated the nonspecific effect, and several explanations have been given (Table 1), including the involvement of prostaglandins (Berliner, 1997;Durand et al, 2004), and sensory nerve stimulation (Morris and Shore, 1996), particularly the axon reflex in primary afferent fibers (Tartas et al, 2005).…”

Section: Nonspecific Vasodilatationmentioning

confidence: 99%

Transdermal iontophoresis as an in-vivo technique for studying microvascular physiology

Tesselaar

Sjöberg

2011

Microvascular Research

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“…Unfortunately, in parallel to the specific effect due to the drug diffused, a so-called ‘non-specific’ vasodilatation (NSV) occurs even when monopolar currents are applied through vehicle solutions that are theoretically devoid of vasoactive properties. NSV remains a puzzling limitation of this otherwise attractive non-invasive technique [1, 2, 3, 4]. …”

Section: Introductionmentioning

confidence: 99%

Anodal Current Intensities above 40 μA Interfere with Current-Induced Axon-Reflex Vasodilatation in Human Skin

Tartas¹,

Durand²,

Koı̈tka³

et al. 2004

J Vasc Res

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When using iontophoresis, the ‘non-specific’ vasodilatation (NSV) that is observed as a result of C-fibre excitation is generally attributed to the local accumulation of protons under the anode. NSV following prolonged 100-µA anodal current application only appears after the current is stopped. Break excitation alone does not explain the delayed onset of this vasodilatation. We hypothesised that this delay could result from an anodal block and thus, that a minimal intensity would be required to achieve hyperpolarisation of primary afferent fibres (mainly C-fibres). Using laser Doppler flowmetry, cutaneous blood flow was recorded in the forearms of 8 healthy volunteers 2 min before current application, during the application and 20 min after stopping the monopolar anodal current. In protocol 1, after 2.5 min of current application at an intensity of 100 µA, the intensity was abruptly decreased to 0–80 µA for a second 2.5-min period. The onset of vasodilatation was only delayed at intensities >30 µA during this second period. In protocol 2, re-application of the current after a 50-second interruption (expected to allow for the occurrence of an axon reflex) did not interfere with the onset of vasodilatation. Thus: (1) the minimal intensity interfering with the axon reflex is far lower than that reported for C-fibre blockade in isolated nerves; (2) the results suggest that current application does not directly interfere with the vasodilator mechanisms induced by the axon reflex at the level of smooth muscle cells.

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Reduced Skin Hyperemia During Tap Water Iontophoresis After Intake of Acetylsalicylic Acid1

Cited by 22 publications

References 12 publications

Current-Induced Vasodilation during Water Iontophoresis (5 min, 0.10 mA) Is Delayed from Current Onset and Involves Aspirin Sensitive Mechanisms

Current-Induced Vasodilation during Water Iontophoresis (5 min, 0.10 mA) Is Delayed from Current Onset and Involves Aspirin Sensitive Mechanisms

Transdermal iontophoresis as an in-vivo technique for studying microvascular physiology

Anodal Current Intensities above 40 μA Interfere with Current-Induced Axon-Reflex Vasodilatation in Human Skin

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