Reduced slow-wave sleep and altered diurnal cortisol rhythms in patients with Addison’s disease

Henry, Michelle; Ross, Ian Louis; Thomas, Kevin G. F.

doi:10.1530/eje-18-0439

Cited by 11 publications

(10 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the participant entered the first phase of SWS or after 90 min of sleep (depending on which came first), the researcher woke the participant briefly and collected the third saliva sample. This sampling method has been used previously in prior research ( Henry et al, 2018 ).…”

Section: Materials and Proceduresmentioning

confidence: 99%

“…These elevated CORT concentrations are of particular relevance here because (a) when night-time CORT concentrations are artificially increased, there tend to be specific effects on sleep stages (viz. SWS) during which the lowest diurnal levels of that hormone are typically observed and during which processes critical to memory consolidation typically occur ( Wagner et al, 2005 ; Henry et al, 2018 ) and (b) brain regions with dense assemblages of glucocorticoid receptors (e.g. prefrontal cortex; de Kloet et al, 2018 ) are heavily involved in PM processes ( Cona et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bedtime Stress Increases Sleep Latency and Impairs Next-Day Prospective Memory Performance

2020

View full text Add to dashboard Cite

The cognitive construct of prospective memory (PM) refers to the capacity to encode, retain and execute delayed intentions (e.g. to remember to buy milk on the way home). Although previous research suggests that PM performance is enhanced by healthy sleep, conclusions tend to be drawn based on designs featuring ecologically unnatural manipulations (e.g. total sleep deprivation). This study investigates whether a more common everyday experience (bedtime stress) affects next-day PM performance and, in so doing, also contributes to the heretofore inconsistent literature on stress and PM. Forty young adults received PM task instructions and were then assigned to either a stress condition (exposure to a laboratory-based stress-induction manipulation; n = 20, 9 women) or a non-stress condition (exposure to a non-stressful control manipulation; n = 20, 12 women). After completing the experimental manipulation, all participants had their objective sleep quality measured over a full night of polysomnographic monitoring. Upon awakening, they completed the PM task. Analyses detected significant between-group differences in terms of stress outcomes, sleep quality and PM performance: Participants exposed to the manipulation experienced heightened signs of stress (captured using a composite variable that included self-report, psychophysiological and endocrinological measures), had longer sleep latencies and poorer sleep depth and displayed significantly longer reaction times to PM cues. An interaction between experimental condition (being exposed to the stressor) and disrupted sleep (longer sleep latency) significantly predicted poorer next-day PM reaction time. We interpret these findings as indicating that bedtime stress, which leads to heightened presleep arousal, affects sleep processes and, consequently, the deployment of attentional resources during next-day execution of a delayed intention.

show abstract

Section: Materials and Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bedtime Stress Increases Sleep Latency and Impairs Next-Day Prospective Memory Performance

2020

View full text Add to dashboard Cite

show abstract

“…However, replacement medication does not restore the natural circadian rhythm of cortisol and, despite adherence, patients experience sub/supra physiological cortisol concentrations, particularly during the night. Patients with AD report and experience both poor-quality sleep and cognitive difficulties (3)(4)(5)(6)(7)(8). One possible (but as yet unexplored) explanation for the sleep disruptions and memory deficits experienced by these patients is that the periods of sub-andsupra-physiological cortisol concentrations they experience may have a specific negative impact on processes of sleep-dependent memory consolidation.…”

Section: Introductionmentioning

confidence: 99%

Sleep, Cognition and Cortisol in Addison’s Disease: A Mechanistic Relationship

2021

Self Cite

View full text Add to dashboard Cite

Sleep is a critical biological process, essential for cognitive well-being. Neuroscientific literature suggests there are mechanistic relations between sleep disruption and memory deficits, and that varying concentrations of cortisol may play an important role in mediating those relations. Patients with Addison’s disease (AD) experience consistent and predictable periods of sub- and supra-physiological cortisol concentrations due to lifelong glucocorticoid replacement therapy, and they frequently report disrupted sleep and impaired memory. These disruptions and impairments may be related to the failure of replacement regimens to restore a normal circadian rhythm of cortisol secretion. Available data provides support for existing theoretical frameworks which postulate that in AD and other neuroendocrine, neurological, or psychiatric disorders, disrupted sleep is an important biological mechanism that underlies, at least partially, the memory impairments that patients frequently report experiencing. Given the literature linking sleep disruption and cognitive impairment in AD, future initiatives should aim to improve patients’ cognitive performance (and, indeed, their overall quality of life) by prioritizing and optimizing sleep. This review summarizes the literature on sleep and cognition in AD, and the role that cortisol concentrations play in the relationship between the two.

show abstract

“…A total of 87–95% of patients with CFS experience unrefreshing sleep [ 35 ]. Prolonged sleep disturbance dysregulates the hypothalamic–pituitary–adrenal (HPA) axis, especially in the metabolism of cortisol, which plays an important role in the stress response and the formation of sleep architecture [ 36 ]. Unlike acute stress, chronic stress induces low levels of serum cortisol and dysfunction of GR dysfunction in the hypothalamus by impeding its translocation and phosphorylation, resulting in a condition that is sometimes called adrenal fatigue [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Korean Red Ginseng Ameliorates Fatigue via Modulation of 5-HT and Corticosterone in a Sleep-Deprived Mouse Model

et al. 2021

View full text Add to dashboard Cite

Central fatigue, which is neuromuscular dysfunction associated with neurochemical alterations, is an important clinical issue related to pathologic fatigue. This study aimed to investigate the anti-central fatigue effect of Korean red ginseng (KRG) and its underlying mechanism. Male BALB/c mice (8 weeks old) were subjected to periodic sleep deprivation (SD) for 6 cycles (forced wakefulness for 2 days + 1 normal day per cycle). Simultaneously, the mice were administered KRG (0, 100, 200, or 400 mg/kg) or ascorbic acid (100 mg/kg). After all cycles, the rotarod and grip strength tests were performed, and then the changes regarding stress- and neurotransmitter-related parameters in serum and brain tissue were evaluated. Six cycles of SD notably deteriorated exercise performance in both the rotarod and grip strength tests, while KRG administration significantly ameliorated these alterations. KRG also significantly attenuated the SD-induced depletion of serum corticosterone. The levels of main neurotransmitters related to the sleep/wake cycle were markedly altered (serotonin was overproduced while dopamine levels were decreased) by SD, and KRG significantly attenuated these alterations through relevant molecules including brain-derived neurotropic factor and serotonin transporter. This study demonstrated the anti-fatigue effects of KRG in an SD mouse model, indicating the clinical relevance of KRG.

show abstract

Reduced slow-wave sleep and altered diurnal cortisol rhythms in patients with Addison’s disease

Cited by 11 publications

References 43 publications

Bedtime Stress Increases Sleep Latency and Impairs Next-Day Prospective Memory Performance

Bedtime Stress Increases Sleep Latency and Impairs Next-Day Prospective Memory Performance

Sleep, Cognition and Cortisol in Addison’s Disease: A Mechanistic Relationship

Korean Red Ginseng Ameliorates Fatigue via Modulation of 5-HT and Corticosterone in a Sleep-Deprived Mouse Model

Contact Info

Product

Resources

About