Reduced striatal activation in females with major depression during the processing of affective stimuli

Connolly, Megan E.; Gollan, Jackie K.; Cobia, Derin; Wang, Xue

doi:10.1016/j.jpsychires.2015.04.025

Cited by 15 publications

(17 citation statements)

References 49 publications

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“…Similar patterns have been found using passive responses to positive and negative stimuli. Studies have observed VS hypoactivation in response to positive word stimuli in MDD (Epstein et al, 2006 ); hypoactivation across the caudate, putamen, and NAc in response to affective pictures in unmedicated females with MDD (Connolly, Gollan, Cobia, & Wang, 2015 ); hypoactivation of the left caudate in response to targets predicting rewarding gustatory stimuli (Antonesei, Murayama, & McCabe, 2018 ); and hypoactivation of the VS in response to happy stimuli (Keedwell, Andrew, Williams, Brammer, & Phillips, 2005 ) and to favourite music (Osuch et al, 2009 ). Furthermore, similar to results using both the MID and guessing tasks, it has also been observed that MDD participants have faster attenuation of NAc activation when listening to preferred music (Jenkins et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

“…Concurring with these medication effects, one study found no striatal hypoactivation during reward liking when using an unmedicated MDD sample (Ubl, Kuehner, Kirsch, Ruttorf, Diener, et al, 2015b). In contrast, though, two others did observe striatal hypoactivation in unmedicated samples (Connolly et al, 2015;Pizzagalli et al, 2009). Interestingly, the study finding no evidence of striatal hypoactivation (Ubl, Kuehner, Kirsch, Ruttorf, Diener, et al, 2015b) and the one presented by Pizzagalli and colleagueswhich did report striatal hypoactivation-both had a sample size of 30 unmedicated individuals with MDD, and the HAM-D average scores were similar (Pizzagalli et al, 2009;Ubl, Kuehner, Kirsch, Ruttorf, Diener, et al, 2015b).…”

Section: Reward Likingmentioning

confidence: 91%

“…Reward liking represents the consummatory stage of reward processing, involving positive or negative hedonic impact (Berridge & Robinson, 2003;Husain & Roiser, 2018;Rømer Thomsen et al, 2015;Treadway & Zald, 2011). The most consistent neuroimaging abnormality associated with reward liking was striatal hypoactivation, reported to be observed in the VS/NAc (Carl et al, 2016;Connolly et al, 2015;Epstein et al, 2006;Foti et al, 2014;Jenkins et al, 2018;Keedwell et al, 2005;Moses-Kolko et al, 2011;Osuch et al, 2009;Pizzagalli et al, 2009;Redlich et al, 2015;Satterthwaite et al, 2015;Steele et al, 2007), caudate (Antonesei et al, 2018;Connolly et al, 2015;Forbes et al, 2006;Forbes et al, 2009;Pizzagalli et al, 2009;Zhang et al, 2013), putamen (Connolly et al, 2015), and right anterior insula (Sankar et al, 2019). Six of these studies reported no anhedonia levels in the participants, but 11 identified higher anhedonia levels in the MDD participants using a variety of anhedonia measures, indicating their ability to inform our understanding of anhedonia.…”

Section: Reward Likingmentioning

confidence: 99%

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Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression

Borsini

Wallis

Zunszain

et al. 2020

Cogn Affect Behav Neurosci

114

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Anhedonia is a key symptom of major depressive disorder (MDD) and comprises behavioural deficits in three reward processing subtypes: reward liking, reward wanting, and reward learning. However, neuroimaging findings regarding the neural abnormalities underpinning these deficits are complex. We have conducted a systematic review to update, reframe and summarize neuroimaging findings across the three subtypes of anhedonia in MDD. Using PubMed, The Cochrane Library, PsycINFO, and Web of Science databases, we identified 59 fMRI studies comparing participants with current or remitted MDD with controls, using reward processing tasks. For reward liking and wanting, striatal hypoactivation was observed, alongside hypoactivation and hyperactivation across frontal regions. For reward learning, blunted frontostriatal sensitivity to positive feedback was observed. These findings highlight the importance of studying anhedonia not only as a clinical manifestation but also as a neurobiological mechanism underlying depressive disorder and other broader psychiatric conditions. Keywords Anhedonia. Depression. Neuroimaging. fMRI. Reward processing Major depressive disorder (MDD) is both common, with a lifetime prevalence of 16.6% in the USA (Kessler, Petukhova, Sampson, Zaslavsky, & Wittchen, 2012), and consequential, being the second leading contributor to global years lived with disability (YLDs) worldwide (Ferrari et al., 2013). Anhedonia is one of two key symptoms required for a diagnosis of MDD in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5; American Psychiatric Association, 2013), and is defined as 'markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day' (American Psychiatric Association, 2013), and so represents a deficit in reward processing. In a study examining the factor structure for DSM-IV, MDD symptoms in a sample 2,615 army recruits, the best fit for the data indicated that MDD consisted of both a somatic and nonsomatic component (Elhai et al., 2012), and anhedonia had the second highest factor weighting (Beta = 0.76) for the nonsomatic component (after depressed mood), as well as the second highest factor weighting of all symptoms (Elhai et al., 2012). This suggests that anhedonia is a core feature of depression. Anhedonia is a symptom which warrants attention; indeed, reward processing deficits are associated with increased risk of new onset MDD (Rawal, Collishaw, Thapar, & Rice, 2013), anhedonia may precede illness onset, and, moreover, it can often persist past the remission of other depressive symptoms (Schrader, 1997), as do deficits on reward processing tasks (Pechtel, Dutra, Goetz, & Pizzagalli, 2013). Three subtypes of anhedonia In DSM-5, anhedonia comprises deficits in hedonic experience of rewards and motivation for rewards (American Psychiatric Association, 2013). However, reviews have called for research to conceptualize anhedonia as comprising deficits across three partially separable subtypes of reward processing:

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Section: Resultsmentioning

confidence: 99%

Section: Reward Likingmentioning

confidence: 91%

Section: Reward Likingmentioning

confidence: 99%

See 1 more Smart Citation

Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression

Borsini

Wallis

Zunszain

et al. 2020

Cogn Affect Behav Neurosci

114

View full text Add to dashboard Cite

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“…Thus, there is some evidence for altered striatal activity associated with cognitive deficits in MDD and the present study adds to this evidence. Further, studies using emotional and reward‐related stimuli have found attenuated activation in the dorsal striatum in depressed samples (Connolly, Gollan, Cobia, & Wang, ; J. P. Hamilton et al, ; Marchand & Yurgelun‐Todd, ; Pizzagalli et al, ). Taken together, these studies make a strong argument for a role of altered striatal activation in MDD.…”

Section: Discussionmentioning

confidence: 99%

Striatal hypoactivation and cognitive slowing in patients with partially remitted and remitted major depression

et al. 2016

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The present pilot study investigated neuronal correlates of executive functioning in patients previously diagnosed with recurrent Major Depressive Disorder (MDD). The aim of the study was to examine a partial remitted and remitted MDD patient group with functional magnetic resonance imaging (fMRI) using a cognitive activation paradigm in order to probe aspects of response inhibition, attention shift and working memory. Twenty MDD patients and 19 healthy controls, matched for age and gender, participated in the study. A working memory n-back task with single presentations of incongruent Stroop words was used, with the instruction to either remember the colour of the ink the word was written in, or the colour word itself, presented 2 or 3 words back in the presentation series. MR images were acquired on a 1.5T GE Signa HD MR scanner. In addition to MR data, response time (RT) and response accuracy (RA) behavioural data were recorded. The behavioural results showed longer RT and lower RA in the MDD group compared to the control group across instruction conditions and working memory load. Based on previous studies of executive function, a composite ROI mask of the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), caudate and putamen was used in statistical analysis. Significant activation was observed in controls throughout this corticostriatal network. When compared to controls, patients showed no significant difference in the level of activation in the ACC and the DLPFC. However, in the putamen and caudate, hypoactivation in the patient group was observed. It was concluded that these effects could be due to a scar effect as a result of previous episodes of MDD.

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“…In addition, a meta- and mega-analysis that integrated data from 20 worldwide cohorts reported distinct patterns of structural brain abnormalities between MDD adults and MDD adolescents [ 13 ]. Regarding functional brain abnormalities, studies have reported that adults with MDD demonstrated reduced activation in the striatum under affective processing task [ 14 ] and reduced activation in the dorsal medial prefrontal cortex during executive tasks [ 15 ]. Neural function studies in youth with MDD, however, have yielded findings that diverge from those in adults.…”

Section: Introductionmentioning

confidence: 99%

Abnormal amygdala resting-state functional connectivity in adults and adolescents with major depressive disorder: A comparative meta-analysis

et al. 2018

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BackgroundAlthough dysfunction of amygdala-related circuits is centrally implicated in major depressive disorder (MDD), little is known about how this dysfunction differs between adult and adolescent MDD patients.MethodsVoxel-wise meta-analyses of abnormal amygdala resting-state functional connectivity (rsFC) were conducted in adult and adolescent groups separately, followed by a quantitative meta-analytic comparison of the two groups.FindingsNineteen studies that included 665 MDD patients (392 adults and 273 adolescents) and 546 controls (341 adults and 205 adolescents) were identified in the current study. Adult-specific abnormal amygdala rsFC in MDD patients compared to that in controls was located mainly within the affective network, including increased connectivity with the right hippocampus/parahippocampus and bilateral ventromedial orbitofrontal cortex and decreased connectivity with the bilateral insula and the left caudate. Adolescent MDD patients specifically demonstrated decreased amygdala rsFC within the cognitive control network encompassing the left dorsolateral prefrontal cortex and imbalanced amygdala rsFC within the default mode network, which was manifested as hyperconnectivity in the right precuneus and hypoconnectivity in the right inferior temporal gyrus. Additionally, direct comparison between the two groups showed that adult patients had strengthened amygdala rsFC with the right hippocampus/parahippocampus as well as the right inferior temporal gyrus and weakened amygdala rsFC with the bilateral insula compared to that in adolescent patients.InterpretationDistinct impairments of amygdala-centered rsFC in adult and adolescent patients were related to different network dysfunctions in MDD. Adult-specific amygdala rsFC dysfunction within the affective network presumably reflects emotional dysregulation in MDD, whereas adolescent-specific amygdala rsFC abnormalities in networks involved in cognitive control might reflect the neural basis of affective cognition deficiency that is characteristic of adolescent MDD.FundThis study was supported by a grant from the National Natural Science Foundation of China (81671669) and by a Sichuan Provincial Youth Grant (2017JQ0001).

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Reduced striatal activation in females with major depression during the processing of affective stimuli

Cited by 15 publications

References 49 publications

Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression

Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression

Striatal hypoactivation and cognitive slowing in patients with partially remitted and remitted major depression

Abnormal amygdala resting-state functional connectivity in adults and adolescents with major depressive disorder: A comparative meta-analysis

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