Reduced subjective quality of life in persons at risk for psychosis

Ruhrmann, Stephan; Paruch, Julia; Bechdolf, Andreas; Pukrop, Ralf; Wagner, Michael; Berning, Julia; Schultze‐Lutter, Frauke; Janssen, Birgit; Gäebel, Wolfgang; Möller, Hans‐Jürgen; Maier, Wolfgang; Klosterkötter, Joachim

doi:10.1111/j.1600-0447.2008.01152.x

Cited by 67 publications

(75 citation statements)

References 56 publications

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“…This is demonstrated by their high levels of hopelessness, depression, anxiety, and poor quality of life, in comparison to other help-seeking patients and patients with first-episode psychosis [30,31,95]. In fact, they often fulfill the diagnostic criteria for other mental disorders that require treatment, in particular depression, anxiety, and substance abuse or dependence [25,42,100].…”

Section: Need For Treatment In Clinical High Risk States Of Psychosesmentioning

confidence: 98%

EPA guidance on the early intervention in clinical high risk states of psychoses

et al. 2015

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This guidance paper from the European Psychiatric Association (EPA) aims to provide evidence-based recommendations on early intervention in clinical high risk (CHR) states of psychosis, assessed according to the EPA guidance on early detection. The recommendations were derived from a meta-analysis of current empirical evidence on the efficacy of psychological and pharmacological interventions in CHR samples. Eligible studies had to investigate conversion rate and/or functioning as a treatment outcome in CHR patients defined by the ultra-high risk and/or basic symptom criteria. Besides analyses on treatment effects on conversion rate and functional outcome, age and type of intervention were examined as potential moderators. Based on data from 15 studies (n=1394), early intervention generally produced significantly reduced conversion rates at 6- to 48-month follow-up compared to control conditions. However, early intervention failed to achieve significantly greater functional improvements because both early intervention and control conditions produced similar positive effects. With regard to the type of intervention, both psychological and pharmacological interventions produced significant effects on conversion rates, but not on functional outcome relative to the control conditions. Early intervention in youth samples was generally less effective than in predominantly adult samples. Seven evidence-based recommendations for early intervention in CHR samples could have been formulated, although more studies are needed to investigate the specificity of treatment effects and potential age effects in order to tailor interventions to the individual treatment needs and risk status.

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Section: Need For Treatment In Clinical High Risk States Of Psychosesmentioning

confidence: 98%

EPA guidance on the early intervention in clinical high risk states of psychoses

et al. 2015

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“…Research within CHR populations suggests that these patients experience considerable distress as well as impairments in social and occupational functioning well before the onset of full-threshold psychotic symptoms Ruhrmann et al, 2008;Velthorst et al, 2010;Cornblatt et al, 2011;Thompson et al, 2015). Screening may be particularly useful for identifying CHR patients at an earlier stage of illness by detecting new-onset symptoms after they have become bothersome to patients, but before they have caused notable impairments.…”

Section: Introductionmentioning

confidence: 96%

Longitudinal validation of psychosis risk screening tools

Kline

Thompson

Demro

et al. 2015

Schizophrenia Research

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“…Therefore, concurrent early treatment of both substance use and mental health problems should be an intervention priority. Early interventions (pharmacotherapies and psychotherapies) have been implemented across studies with individuals at risk of developing a psychotic disorder, but so far focus has been solely on interventions targeting psychopathology as a way of preventing conversion to full-scale psychosis rather than focusing on the effects of and interactions with substance use [85,86].…”

Section: Prevention Of Cannabis Use In Patients With Early-onset Psycmentioning

confidence: 99%

Cannabis Abuse and Vulnerability to Psychosis: Targeting Preventive Services

Kolliakou

Fusar‐Poli

Atakan

2012

CPD

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Cannabis is the most widely used illicit substance in the world and due to the high levels of use observed among young people with psychosis, most research has focused on the causal relationship between cannabis use and mental health problems. Despite a large interest in developing intervention models to target this group, there are as yet no established and effective methods of prevention and intervention focusing on cannabis use. In this paper we present the available evidence for the effectiveness of substance use treatments in patients with co-morbid severe mental illness, as well as exploring the prevention and early intervention initiatives for substance use in the general population.

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Reduced subjective quality of life in persons at risk for psychosis

Abstract: Individuals at risk for psychosis experienced a marked impairment of sQoL across all domains. This was evident even in the early state, showed no significant further deterioration during the late state and was predominantly explained by non-specific symptoms.

Cited by 67 publications

References 56 publications

EPA guidance on the early intervention in clinical high risk states of psychoses

EPA guidance on the early intervention in clinical high risk states of psychoses

Longitudinal validation of psychosis risk screening tools

Cannabis Abuse and Vulnerability to Psychosis: Targeting Preventive Services

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