Reduced Sulcal Depth in Central Sulcus of Major Depressive Disorder

Shin, Seung-Joon; Kim, Aram; Han, Kook Nam; Tae, Woo Suk; Ham, Byung‐Joo

doi:10.5607/en22031

Cited by 8 publications

(5 citation statements)

References 32 publications

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“…While deepening and widening sulci are normal aspects of the aging process, 31 these morphological changes are often accelerated in patients with neurodegenerative and psychiatric disorders. [32][33][34][35] In our sample, greater sulcal depth was notable in football players, especially in the superior/middle frontal gyri and cingulate regions, which govern complex movement and the default mode network. Several computational studies suggest that the greatest tissue deformation occurs in the deepest sulci upon traumatic insult 36 due to the cerebral spinal fluid rapidly clustering in the base of the sulci and causing shearing waves, referred to as water hammer effect.…”

Section: Discussionmentioning

confidence: 63%

Cerebral Cortical Surface Structure and Neural Activation Pattern Among Adolescent Football Players

Zuidema,

Hou,

Kercher

et al. 2024

JAMA Netw Open

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ImportanceRecurring exposure to head impacts in American football has garnered public and scientific attention, yet neurobiological associations in adolescent football players remain unclear.ObjectiveTo examine cortical structure and neurophysiological characteristics in adolescent football players.Design, Setting, and ParticipantsThis cohort study included adolescent football players and control athletes (swimming, cross country, and tennis) from 5 high school athletic programs, who were matched with age, sex (male), and school. Neuroimaging assessments were conducted May to July of the 2021 and 2022 seasons. Data were analyzed from February to November 2023.ExposurePlaying tackle football or noncontact sports.Main Outcomes and MeasuresStructural magnetic resonance imaging (MRI) data were analyzed for cortical thickness, sulcal depth, and gyrification, and cortical surface-based resting state (RS)–functional MRI analyses examined the amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and RS-functional connectivity (RS-FC).ResultsTwo-hundred seventy-five male participants (205 football players; mean [SD] age, 15.8 [1.2] years; 5 Asian [2.4%], 8 Black or African American [3.9%], and 189 White [92.2%]; 70 control participants; mean [SD] age 15.8 [1.2] years, 4 Asian [5.7], 1 Black or African American [1.4%], and 64 White [91.5%]) were included in this study. Relative to the control group, the football group showed significant cortical thinning, especially in fronto-occipital regions (eg, right precentral gyrus: t = −2.24; P = .01; left superior frontal gyrus: −2.42; P = .002). Elevated cortical thickness in football players was observed in the anterior and posterior cingulate cortex (eg, left posterior cingulate cortex: t = 2.28; P = .01; right caudal anterior cingulate cortex 3.01; P = .001). The football group had greater and deeper sulcal depth than the control groups in the cingulate cortex, precuneus, and precentral gyrus (eg, right inferior parietal lobule: t = 2.20; P = .004; right caudal anterior cingulate cortex: 4.30; P &lt; .001). Significantly lower ALFF was detected in the frontal lobe and cingulate cortex of the football group (t = −3.66 to −4.92; P &lt; .01), whereas elevated ALFF was observed in the occipital regions (calcarine and lingual gyrus, t = 3.20; P &lt; .01). Similar to ALFF, football players exhibited lower ReHo in the precentral gyrus and medial aspects of the brain, such as precuneus, insula, and cingulum, whereas elevated ReHo was clustered in the occipitotemporal regions (t = 3.17; P &lt; .001; to 4.32; P &lt; .01). There was no group difference in RS-FC measures.Conclusions and RelevanceIn this study of adolescent athletes, there was evidence of discernible structural and physiological differences in the brains of adolescent football players compared with their noncontact controls. Many of the affected brain regions were associated with mental health well-being.

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Section: Discussionmentioning

confidence: 63%

Cerebral Cortical Surface Structure and Neural Activation Pattern Among Adolescent Football Players

Zuidema,

Hou,

Kercher

et al. 2024

JAMA Netw Open

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“…Notably, sulcal depth exhibited very large S estimates globally with few exceptions. This “fingerprint”-like phenomenon is particularly interesting given the associations that have previously been found between sulcal depth and aging (Rettmann et al 2006) as well as mental health (Shin et al 2022). These results imply that all three phenotypes, and particularly sulcal depth, are subject to a substantial amount of influence from environmental factors that are not shared among twins or siblings, which may include random influences during development or unique experiences that influence individual patterns of cortical maturation (Tamnes et al 2017).…”

Section: Discussionmentioning

confidence: 85%

“…This "fingerprint"-like phenomenon is particularly interesting given the associations that have previously been found between sulcal depth and aging 16 as well as mental health. 17 These results imply that all three phenotypes, and particularly sulcal depth, are subject to a substantial amount of influence from environmental factors that are not shared among twins or siblings, which may include random influences during development or unique experiences that influence individual patterns of cortical maturation. 18 The present study confirms and extends prior literature estimating heritability of cortical phenotypes in adolescents 6 , using a novel statistical package to leverage the full ABCD Study ® sample across multiple timepoints.…”

Section: Discussionmentioning

confidence: 87%

Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components

Smith

Parekh

Kennedy

et al. 2023

Preprint

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The relative contributions of genetic variation and experience in shaping the morphology of the adolescent brain are not fully understood. Using longitudinal data from 11,665 subjects in the ABCD Study, we fit vertex-wise variance components including family effects, genetic effects, and subject-level effects using a computationally efficient framework. Variance in cortical thickness and surface area is largely attributable to genetic influence, whereas sulcal depth is primarily explained by subject-level effects.

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“…Sulcal depth has been studied as an important neuroimaging biomarker for brain diseases and has been widely used to study the morphological characteristics of cerebral folding (Im et al, 2008;Shin et al, 2022). The more sulcal depth of fusiform in musicians can be explained as musicians' domain speci city and perceptual expertise by their cortical folding patterns, which was tightly connected with human's postcentral gyrus in cognitive development (Yao et al, 2023).…”

Section: Fractal Dimensionality and Sulcal Depth-musicians Versus Non...mentioning

confidence: 99%

Structural brain morphometry differences between musicians and nonmusicians

Liu,

Zheng,

Hou

2024

Preprint

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Music can affect the functional activities and morphological basis of internal brain nerves. In contrast to the functional activity of brain, the characteristics of structural brain morphometry between musicians and nonmusicians are often overlooked, which also limits the practical use of music’s emotional, cognitive and motor functions. By comparing the differences of structural morphometry between sixteen musicians and seventeen nonmusicians, significant differences were found in cortical thickness, fractal dimensionality, gyrification, and sulcal depth. Compared with nonmusicians, musicians showed greater cortical thickness advantages in the left superior frontal gyrus and the right central parietal region, and showed structural advantages in fractal dimensionality and sulcal depth in the left fusiform gyrus and the right central region. In contrast, nonmusicians had more prominent gyrification in the bilateral insula, right superior parietal lobule, and right supramarginal gyrus than musicians. More importance, the interactive effects between gender and cortical thickness, fractal dimensionality, gyrification, and sulcal depth were significant in limbic system (the hippocampus, cingulate gyrus, insula gyrus, fusiform, and precuneus). In conclusion, the differences of frontal area, limbic system, and sensorimotor areas of structural brain morphometry between musicians and nonmusicians provide straight evidence of brain structure for brain function of music, and also provides guidance for improving the mental health and neuroplasticity of music.

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Reduced Sulcal Depth in Central Sulcus of Major Depressive Disorder

Cited by 8 publications

References 32 publications

Cerebral Cortical Surface Structure and Neural Activation Pattern Among Adolescent Football Players

Cerebral Cortical Surface Structure and Neural Activation Pattern Among Adolescent Football Players

Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components

Structural brain morphometry differences between musicians and nonmusicians

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